Abstract
Obesity is a major risk factor for the development of multiple cancers. In efforts to develop models that will assist the scientific community in studying the mechanisms of this risk, a diet-induced obesity model of obesity is often utilized. Here we describe the use of diet-induced obesity (DIO) diets to study the effects of high-fat diet weight gain in the context of cancer mouse models.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Ogden CL, Carroll MD, Kit BK, Flegal KM (2014) Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA 311:806–814. https://doi.org/10.1001/jama.2014.732
Wang YC, McPherson K, Marsh T, Gortmaker SL, Brown M (2011) Health and economic burden of the projected obesity trends in the USA and the UK. Lancet 378:815–825. https://doi.org/10.1016/S0140-6736(11)60814-3
Steele CB et al (2017) Vital signs: trends in incidence of cancers associated with overweight and obesity—United States, 2005–2014. MMWR Morb Mortal Wkly Rep 66:1052–1058. https://doi.org/10.15585/mmwr.mm6639e1
Lutz TA, Woods SC (2012) Overview of animal models of obesity. Curr Protoc Pharmacol. Chapter 5, Unit5 61. https://doi.org/10.1002/0471141755.ph0561s58
Tschop M, Heiman ML (2001) Rodent obesity models: an overview. Exp Clin Endocrinol Diabetes 109:307–319. https://doi.org/10.1055/s-2001-17297
Johnson PR, Greenwood MR, Horwitz BA, Stern JS (1991) Animal models of obesity: genetic aspects. Annu Rev Nutr 11:325–353. https://doi.org/10.1146/annurev.nu.11.070191.001545
Hariri N, Thibault L (2010) High-fat diet-induced obesity in animal models. Nutr Res Rev 23:270–299. https://doi.org/10.1017/S0954422410000168
Philip B et al (2013) A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice. Gastroenterology 145:1449–1458. https://doi.org/10.1053/j.gastro.2013.08.018
Gomez-Chou S et al (2017) Lipocalin-2 promotes pancreatic ductal adenocarcinoma by regulating inflammation in the tumor microenvironment. Cancer Res 77(10):2647–2660. https://doi.org/10.1158/0008-5472.CAN-16-1986
Good DJ (2005) Using obese mouse models in research: special considerations for IACUC members, animal care technicians, and researchers. Lab Anim 34:30–37. https://doi.org/10.1038/laban0205-30
Montgomery MK et al (2013) Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding. Diabetologia 56:1129–1139. https://doi.org/10.1007/s00125-013-2846-8
Chang HH et al (2017) Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice. PLoS One 12:e0184455. https://doi.org/10.1371/journal.pone.0184455
Acknowledgments
Conflict of Interest: The authors declare no conflicts of interest.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 The Author(s)
About this protocol
Cite this protocol
Badi, N., Cruz-Monserrate, Z. (2022). Murine Model of Obesity-Induced Cancer. In: McAllister, F. (eds) Cancer Immunoprevention. Methods in Molecular Biology, vol 2435. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2014-4_14
Download citation
DOI: https://doi.org/10.1007/978-1-0716-2014-4_14
Published:
Publisher Name: Humana, New York, NY
Print ISBN: 978-1-0716-2013-7
Online ISBN: 978-1-0716-2014-4
eBook Packages: Springer Protocols