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Chemical Synthesis and Immunomodulatory Functions of Bacterial Lipid As

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Glycolipids

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2613))

Abstract

Lipopolysaccharide (LPS), a cell surface component of Gram-negative bacteria, and its active principle, lipid A, have immunostimulatory properties and thus potential to act as adjuvants. However, canonical LPS acts as an endotoxin by hyperstimulating the immune response. Therefore, it is necessary to structurally modify LPS and lipid A to minimize toxicity while maintaining adjuvant effects for use as vaccine adjuvants. Various studies have focused on the chemical synthetic method of lipid As and their structure-activity relationship, which are reviewed in this chapter.

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Authors and Affiliations

  1. Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan

    Atsushi Shimoyama & Koichi Fukase

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  1. Atsushi Shimoyama
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  2. Koichi Fukase
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Correspondence to Atsushi Shimoyama .

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Editors and Affiliations

  1. Department of Chemistry, Graduate School of Science, Osaka University, Osaka, Japan

    Kazuya Kabayama

  2. Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Japan

    Jin-ichi Inokuchi

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Shimoyama, A., Fukase, K. (2023). Chemical Synthesis and Immunomodulatory Functions of Bacterial Lipid As. In: Kabayama, K., Inokuchi, Ji. (eds) Glycolipids. Methods in Molecular Biology, vol 2613. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2910-9_4

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  • DOI: https://doi.org/10.1007/978-1-0716-2910-9_4

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