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A Review of High-Dimensional Mediation Analyses in DNA Methylation Studies

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Epigenome-Wide Association Studies

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2432))

Abstract

DNA methylation alterations have been widely studied as mediators of environmentally induced disease risks. With new advances in technique, epigenome-wide DNA methylation data (EWAS) have become the new standard for epigenetic studies in human populations. However, to date most epigenetic studies of mediation effects only involve selected (gene-specific) candidate methylation markers. There is an urgent need for appropriate analytical methods for EWAS mediation analysis. In this chapter, we provide an overview of recent advances on high-dimensional mediation analysis, with application to two DNA methylation data.

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Acknowledgements

The work of Haixiang Zhang is partially supported by Science Foundation of Tianjin University (No. 2018XRG-0038). The work of Lei Liu is partially supported by the Washington University Institute of Clinical and Translational Sciences grant UL1TR000448 from the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH) and NIH R21 AG063370.

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Authors and Affiliations

  1. Center for Applied Mathematics, Tianjin University, Tianjin, China

    Haixiang Zhang

  2. Department of Preventive Medicine, Northwestern University, Chicago, IL, USA

    Lifang Hou

  3. Division of Biostatistics, Washington University in St. Louis, St. Louis, MO, USA

    Lei Liu

Authors
  1. Haixiang Zhang
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  2. Lifang Hou
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  3. Lei Liu
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Correspondence to Lei Liu .

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Editors and Affiliations

  1. University of Minnesota, Minneapolis, MN, USA

    Weihua Guan

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Zhang, H., Hou, L., Liu, L. (2022). A Review of High-Dimensional Mediation Analyses in DNA Methylation Studies. In: Guan, W. (eds) Epigenome-Wide Association Studies. Methods in Molecular Biology, vol 2432. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1994-0_10

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  • DOI: https://doi.org/10.1007/978-1-0716-1994-0_10

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1993-3

  • Online ISBN: 978-1-0716-1994-0

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