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Smartphone-Based Electrochemical System for Biosensors and Biodetection

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Biomedical Engineering Technologies

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2393))

Abstract

With the advantages of high popularity, convenient operation, open-source operation systems, high resolution imaging, and excellent computing capabilities, smartphones have been widely used as the core of detection system for calculation, control, and real-time display. Hence, smartphones play an important role in electrochemical detection and optical detection. Smartphone-based electrochemical systems were combined with screen-printed electrode and interdigital electrodes for in situ detection. The electrodes were modified with biomaterials, chemical materials, and nanomaterials for biosensors and biodetection, such as 3-amino phenylboronic acid nanocomposites, graphene, gold nanoparticles, zinc oxide nanoparticles, carbon nanotubes, proteins, peptides, and antibodies. With the modified electrodes, the smartphone-based impedance system was used to detect acetone, bovine serum albumin, human serum albumin, and trinitrotoluene, while smartphone-based amperometric system was employed to monitor glucose, ascorbic acid, dopamine, uric acid, and levodopa. The smartphone-based electrochemical system for biosensors and biodetection has provided miniaturized and portable alternative for diagnosis, which is promising to find application in point-of-care testing (POCT).

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Acknowledgments

This work was supported by National Key Research and Development Program (Grant No. 2018YFC1707701), the National Natural Science Foundation of China (Grant No. 81801793, 31671007), the China Postdoctoral Science Foundation (Grant No. 2018 M630677, 2019 T120518).

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Authors and Affiliations

  1. Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, People’s Republic of China

    Daizong Ji, Sze Shin Low, Diming Zhang, Lei Liu, Yanli Lu & Qingjun Liu

Authors
  1. Daizong Ji
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  2. Sze Shin Low
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  3. Diming Zhang
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  4. Lei Liu
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  5. Yanli Lu
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  6. Qingjun Liu
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Corresponding author

Correspondence to Qingjun Liu .

Editor information

Editors and Affiliations

  1. Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Bethesda, MD, USA

    Miguel R. Ossandon

  2. Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, MD, USA

    Houston Baker

  3. Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, MD, USA

    Avraham Rasooly

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Ji, D., Low, S.S., Zhang, D., Liu, L., Lu, Y., Liu, Q. (2022). Smartphone-Based Electrochemical System for Biosensors and Biodetection. In: Ossandon, M.R., Baker, H., Rasooly, A. (eds) Biomedical Engineering Technologies. Methods in Molecular Biology, vol 2393. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1803-5_26

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  • DOI: https://doi.org/10.1007/978-1-0716-1803-5_26

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1802-8

  • Online ISBN: 978-1-0716-1803-5

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