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Strategies to Modulate the Blood-Brain Barrier for Directed Brain Tumor Targeting

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Nanotherapy for Brain Tumor Drug Delivery

Part of the book series: Neuromethods ((NM,volume 163))

Abstract

Glioblastoma (GBM) is the most common and aggressive primary brain tumors in adults. Despite being one of the most genetically and molecularly characterized tumors, patient prognosis remains dismal. Many factors have contributed to the challenges of developing effective clinical therapies, such as tumor heterogeneity, immune-suppressive microenvironment, and therapy resistance. From the perspective of therapeutics delivery, one of the main obstacles is to get newly discovered therapeutic agents across the blood-brain barrier (BBB) to penetrate the brain parenchyma. In this context, this book chapter provides an overview of three different strategies of delivering antitumor agents intended to circumvent the BBB and highlight the strengths and weakness of each approach.

Author Contributions

Conceptualization: PS, MLV, RA, HS, HC, AQH. Formal Analysis: PS, MLV, RA, HS. Writing: PS, MLV, RA, HS. Visualization: PS, MLV, RA. Supervision: AQH, HC. Funding Acquisition: AQH, HC. Resources: AQH, HC.

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Acknowledgments

We will like to thank Nick Ellens, PhD, for optimizing sonication parameters for MRIgFUS. AQH, PS, RA, and MLV are supported by NIH grants CA183827, CA195503, CA216855, and CA200399. MLV is also supported by CONACYT and PECEM from the National Autonomous University of Mexico.

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Authors and Affiliations

  1. Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA

    Paula Schiapparelli, Montserrat Lara-Velazquez, Rawan Al-kharboosh & Alfredo Quinones-Hinojosa

  2. School of Medicine, PECEM from the National Autonomous University of Mexico, Mexico City, Mexico

    Montserrat Lara-Velazquez

  3. Mayo Clinic College of Medicine, Mayo Clinic Graduate School, Neuroscience, Rochester, MN, USA

    Rawan Al-kharboosh

  4. Department of Chemical and Biomolecular Engineering and Institute for Nanobiotechnology, The Johns Hopkins University, Baltimore, MD, USA

    Hao Su & Honggang Cui

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  1. Paula Schiapparelli
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  2. Montserrat Lara-Velazquez
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  3. Rawan Al-kharboosh
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  4. Hao Su
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  5. Honggang Cui
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  6. Alfredo Quinones-Hinojosa
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Correspondence to Paula Schiapparelli .

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Editors and Affiliations

  1. CONRAD / Eastern Virginia Medical School, Arlington, VA, USA

    Vivek Agrahari

  2. Department of Neurosurgery and Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USA

    Anthony Kim

  3. Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Science Center, Oklahoma City, OK, USA

    Vibhuti Agrahari

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Schiapparelli, P., Lara-Velazquez, M., Al-kharboosh, R., Su, H., Cui, H., Quinones-Hinojosa, A. (2021). Strategies to Modulate the Blood-Brain Barrier for Directed Brain Tumor Targeting. In: Agrahari, V., Kim, A., Agrahari, V. (eds) Nanotherapy for Brain Tumor Drug Delivery. Neuromethods, vol 163. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1052-7_3

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  • DOI: https://doi.org/10.1007/978-1-0716-1052-7_3

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