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Nanofibers and Nanostructured Scaffolds for Nervous System Lesions

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Nanomedicines for Brain Drug Delivery

Part of the book series: Neuromethods ((NM,volume 157))

Abstract

Strategies aimed at repairing the injured nervous system have as their main goal the reconnection of axons with their appropriate targets through bridging devices. In order to achieve this, such devices must provide cues to support directed axonal growth and good integration with the host tissue. Differences in the anatomy of the central nervous system (CNS) and the peripheral nervous system (PNS) as well as their specific tissue response after injury, where the protective environment in the CNS contrasts with the more permissive one in the PNS, require strategies to be tailored for these specific locations. This chapter focuses on the development of nanostructured scaffolds (including hydrogels) in the formulation of strategies intended to promote axon regeneration and functional tissue repair following traumatic spinal cord injury (SCI) and peripheral nerve injury (PNI). The reader will be presented with a general introduction to the central nervous system and the peripheral nervous system, the pathophysiological consequences of such injuries, their incidence, and how advances in the state of the art of bioengineering nanostructured scaffolds are contributing to this important aspect of tissue engineering and regenerative medicine.

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Authors and Affiliations

  1. Institute of Neuropathology, University Hospital RWTH Aachen, Aachen, Germany

    Jose L. Gerardo Nava & Gary A. Brook

  2. DWI – Leibniz-Institute for Interactive Materials, Aachen, Germany

    Jose L. Gerardo Nava, Jonas C. Rose & Laura De Laporte

  3. Department of Neurosurgery, University Hospital RWTH Aachen, Aachen, Germany

    Haktan Altinova

  4. Department for Functional Materials in Medicine and Dentistry and Bavarian Polymer Institute, University of Würzburg, Würzburg, Germany

    Paul D. Dalton

  5. Insitute of Applied Medical Engineering, RWTH Aachen University, Aachen, Germany

    Laura De Laporte

  6. Insitute of Technical and Macromolecular Chemistry, RWTH Aachen University, Aachen, Germany

    Laura De Laporte

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  1. Jose L. Gerardo Nava
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  2. Jonas C. Rose
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  3. Haktan Altinova
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  4. Paul D. Dalton
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  5. Laura De Laporte
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  6. Gary A. Brook
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Corresponding authors

Correspondence to Jose L. Gerardo Nava or Gary A. Brook .

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Editors and Affiliations

  1. Department of Pharmaceutical Science and Technology, University of Chile, Santiago, Chile

    Javier O. Morales

  2. 2-BBB Medicines BV, Leiden, The Netherlands

    Pieter J. Gaillard

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Gerardo Nava, J.L., Rose, J.C., Altinova, H., Dalton, P.D., De Laporte, L., Brook, G.A. (2021). Nanofibers and Nanostructured Scaffolds for Nervous System Lesions. In: Morales, J.O., Gaillard, P.J. (eds) Nanomedicines for Brain Drug Delivery. Neuromethods, vol 157. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0838-8_3

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