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Targeting Epithelial-to-Mesenchymal Transition for Breast Cancer Stem Cells Therapeutics

  • Living reference work entry
  • First Online:
Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

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Abstract

Metastasis of breast cancer cells involves the dissemination from primary tumor sites and migration to distant organs forming secondary tumors, which causes a major hurdle to breast cancer treatment. Epithelial-to-Mesenchymal Transition (EMT) has been extensively studied in mammalian embryogenesis and disease conditions such as breast cancer invasion and metastasis. Any disturbance in the fine balance between the epithelial and mesenchymal phenotypes of breast cancer cells promotes metastatic development. EMT-induction in aggressive breast cancer cells gives rise to a subset of breast cancer stem cells (CSCs) which are highly migratory in nature and leads to resistance against chemotherapy. In this chapter, we analyze the EMT pathways and the interactions of EMT genes involved in breast cancer progression. We also analyze the promoter interactions of EMT genes with EMT transcription factors using in silico analysis and validate the mRNA expression of EMT genes in various breast cancer cells in literature. Finally, we analyze the interactions between EMT-TFs and genes with novel small molecules at preclinical stages and clinically approved drugs that can effectively target the breast CSCs to treat aggressive breast cancers. This study was intended to explore molecular EMT factors on breast CSCs that can be effectively targeted to mitigate breast cancer by repurposing of drugs.

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Acknowledgments

AD acknowledges institutional funding provided by the Council of Scientific and Industrial Research (CSIR), Ministry of Science & Technology, Government of India for Projects under Healthcare theme. The fellowship provided by CSIR-JRF/SRF to SS and DS is gratefully acknowledged (Manuscript Communication number: IICT/Pubs./2021/238).

Competing Interests

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Applied Biology, Council of Scientific & Industrial Research-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, Telangana, India

    Shruthi Suthakaran M.Tech, Digvijay Singh M.Sc., Rohit K. Deshmukh M.Tech & Amitava Das Ph.D.

  2. Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, India

    Shruthi Suthakaran M.Tech, Digvijay Singh M.Sc. & Amitava Das Ph.D.

Authors
  1. Shruthi Suthakaran M.Tech
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  2. Digvijay Singh M.Sc.
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  3. Rohit K. Deshmukh M.Tech
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  4. Amitava Das Ph.D.
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Corresponding author

Correspondence to Amitava Das Ph.D. .

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Editors and Affiliations

  1. Dept Biochem & Biophysics, C-Block, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

Section Editor information

  1. Cellular Stress and Immune Response Laboratory, Centre for Cancer Biology, University of South Australia, Adelaide, South Australia, Australia

    Nirmal Robinson

  2. Department of Morphofunctional Sciences, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania

    Cornelia Amalinei

  3. Department of Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana State, India

    Amitava Das

  4. Biological Sciences, Academy of Scientific and Innovative Research, Ghaziabad,, UP, India

    Amitava Das

  5. Chettinad Hospital & Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Chennai, Tamil Nadu, India

    Surajit Pathak

  6. Stem Cell Facility, DBT-Centre of Excellence for Stem Cell Research, All India Institute of Medical Sciences, New Delhi, India

    Sujata Mohanty

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Suthakaran, S., Singh, D., Deshmukh, R.K., Das, A. (2022). Targeting Epithelial-to-Mesenchymal Transition for Breast Cancer Stem Cells Therapeutics. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-1247-3_241-1

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  • DOI: https://doi.org/10.1007/978-981-16-1247-3_241-1

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  • Print ISBN: 978-981-16-1247-3

  • Online ISBN: 978-981-16-1247-3

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