Abstract
Anthocyanins are a group of water-soluble pigments in the colorful plant world, which can be used as additives in food. Anthocyanins have a basic structure of flavonoid, which have shown outstanding antioxidative effects. The daily intake of anthocyanins is abundant, and they are inversely correlated with various kinds of chronic diseases, according to the epidemiological study. Anthocyanins have anti-inflammatory effects, could regulate lipid metabolism, ameliorate insulin resistance, and improve cholesterol efflux in foam cells, which can prevent and alleviate chronic diseases such as cardiovascular diseases, diabetes mellitus, neurosis, visual degradation, cancer, and so on. However, the bioavailability of anthocyanins was proved low, which may restrict the bioactivity of anthocyanins. Some of the studies reported that the metabolites of anthocyanins could be the active compounds to prevent diseases. The commercialized products of anthocyanins are emerging in the market these years, but their development is not enough, thereby calling for more careful and systematic studies.
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References
Amatori S, Mazzoni L, Alvarez-Suarez JM, Giampieri F, Gasparrini M, Forbes-Hernandez TY, Afrin S, Errico PA, Persico G, Mezzetti B (2016) Polyphenol-rich strawberry extract (PRSE) shows in vitro and in vivo biological activity against invasive breast cancer cells. Sci Rep 6:30917
Aqil F, Jeyabalan J, Munagala R, Singh IP, Gupta RC (2016) Prevention of hormonal breast cancer by dietary jamun. Mol Nutr Food Res 60:1470–1481
Bennet D, Kang SC, Gang J, Kim S (2014) Photoprotective effects of apple peel nanoparticles. Int J Nanomedicine 9:93–108
Bitsch R, Netzel M, Frank T, Strass G, Bitsch I (2004) Bioavailability and biokinetics of anthocyanins from red grape juice and red wine. J Biomed Biotechnol 2004:293
Blank F (1947) The anthocyanin pigments of plants. Bot Rev 13:241–317
Bub A, Watzl B, Heeb D, Rechkemmer G, Briviba K (2001) Malvidin-3-glucoside bioavailability in humans after ingestion of red wine, dealcoholized red wine and red grape juice. Eur J Nutr 40:113–120
Castañeda-Ovando A, Pacheco-Hernández MdL, Páez-Hernández ME, Rodríguez JA, Galán-Vidal CA (2009) Chemical studies of anthocyanins: a review. Food Chem 113:859–871
Chen X-Y, Huang IM, Hwang LS, Ho C-T, Li S, Lo C-Y (2014) Anthocyanins in blackcurrant effectively prevent the formation of advanced glycation end products by trapping methylglyoxal. J Funct Foods 8:259–268
Escher GB, Santos JS, Rosso ND, Marques MB, Azevedo L, Carmo MAVD, Daguer H, Molognoni L, Prado-Silva LD, Sant’Ana AS (2018) Chemical study, antioxidant, anti-hypertensive, and cytotoxic/cytoprotective activities of Centaurea cyanus L. petals aqueous extract. Food Chem Toxicol 118:439–453
Fang J (2014) Bioavailability of anthocyanins. Drug Metab Rev 46:508–520
Godos J, Castellano S, Ray S, Grosso G, Galvano F (2018) Dietary polyphenol intake and depression: results from the Mediterranean Healthy Eating, Lifestyle and Aging (MEAL) Study. Molecules. 23(5). pii: E999
Gordillo B, Rodríguez-Pulido FJ, Escudero-Gilete ML, González-Miret ML, Heredia FJ (2012) Comprehensive colorimetric study of anthocyanic copigmentation in model solutions. Effects of pH and molar ratio. J Agric Food Chem 60:2896–2905
Haskellramsay CF, Stuart RC, Okello EJ, Watson AW (2017) Cognitive and mood improvements following acute supplementation with purple grape juice in healthy young adults. Eur J Nutr 56:1–1
Hung T-C, Chang T-T, Fan M-J, Lee C-C, Chen CY-C (2014) In silico insight into potent of anthocyanin regulation of FKBP52 to prevent Alzheimer’s disease. Evid Based Complement Alternat Med 2014:1
Jennings A, Welch AA, Fairweather-Tait SJ, Kay C, Minihane AM, Chowienczyk P, Jiang B, Cecelja M, Spector T, Macgregor A, Cassidy A (2012) Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women. Am J Clin Nutr 96:781–788
Jiang X, Li X, Zhu C, Sun J, Tian L, Chen W, Bai W (2018a) The target cells of anthocyanins in metabolic syndrome. Crit Rev Food Sci Nutr. 59(6):921–946.
Jiang X, Zhu C, Li X, Sun J, Tian L, Bai W (2018b) Cyanidin-3-O-glucoside at Low Doses Protected against 3-Chloro-1,2-propanediol induced testis injury and improved spermatogenesis in male rats. J Agric Food Chem 66:12675
Kalt W, Mcdonald JE, Vinqvist-Tymchuk MR, Liu Y, Sae F (2017) Human anthocyanin bioavailability: effect of intake duration and dosing. Food Funct 8:4563–4569
Kamonpatana K, Failla ML, Kumar PS, Giusti MM (2014) Anthocyanin structure determines susceptibility to microbial degradation and bioavailability to the Buccal Mucosa. J Agric Food Chem 62:6903–6910
Kay CD (2006) Aspects of anthocyanin absorption, metabolism and pharmacokinetics in humans. Nutr Res Rev 19:137–146
Kim HG, Ju MS, Shim JS, Kim MC, Lee S-H, Huh Y, Kim SY, Oh MS (2010) Mulberry fruit protects dopaminergic neurons in toxin-induced Parkinson’s disease models. Br J Nutr 104:8–16
Kim B, Ku CS, Pham TX, Park Y, Martin DA, Xie L, Taheri R, Lee J, Bolling BW (2013) Aronia melanocarpa (chokeberry) polyphenol-rich extract improves antioxidant function and reduces total plasma cholesterol in apolipoprotein E knockout mice. Nutr Res (New York, NY) 33:406–413
Kong J-M, Chia L-S, Goh N-K, Chia T-F, Brouillard R (2003) Analysis and biological activities of anthocyanins. Phytochemistry 64:923–933
Lee M, Sorn SR, Park Y, Park HK (2016) Anthocyanin rich-black soybean testa improved visceral fat and plasma lipid profiles in overweight/obese korean adults: a randomized controlled trial. J Med Food 19:995
Li L, Wang L, Wu Z, Yao L, Wu Y, Huang L, Liu K, Zhou X, Gou D (2013) Anthocyanin-rich fractions from red raspberries attenuate inflammation in both RAW264.7 macrophages and a mouse model of colitis. Sci Rep 4:6234
Liobikas J, Skemiene K, Trumbeckaite S, Borutaite V (2016) Anthocyanins in cardioprotection: a path through mitochondria. Pharmacol Res 113:808–815
Liu Y, Li D, Zhang Y, Sun R, Xia M (2014) Anthocyanin increases adiponectin secretion and protects against diabetes-related endothelial dysfunction. Am J Physiol Endocrinol Metabol 306:E975–E988
Liu ZH, Hu YF, Li X, Mei ZX, Wu S, He Y, Jiang XW, Sun JX, Xiao JB, Deng LH, Bai WB (2018) Nanoencapsulation of cyanidin-3-O-glucoside enhances protection against UVB-induced epidermal damage through regulation of p53-mediated apoptosis in mice. J Agric Food Chem 66:5359–5367
Maciel LG, Mav DC, Azevedo L, Daguer H, Molognoni L, de Almeida MM, Granato D, Rosso ND (2018) Hibiscus sabdariffa anthocyanins-rich extract: chemical stability, in vitro antioxidant and antiproliferative activities. Food Chem Toxicol 113:187
Mueller D, Jung K, Winter M, Rogoll D, Melcher R, Richling E (2017) Human intervention study to investigate the intestinal accessibility and bioavailability of anthocyanins from bilberries. Food Chem 231:275–286
Mueller D, Jung K, Winter M, Rogoll D, Melcher R, Kulozik U, Schwarz K, Richling E (2018) Encapsulation of anthocyanins from bilberries – effects on bioavailability and intestinal accessibility in humans. Food Chem 248:217
Ohguro I, Ohguro H, Nakazawa M (2008) Effects of anthocyanins in black currant on retinal blood flow circulation of patients with normal tension glaucoma. A pilot study. Hirosaki Med J 59:23–32
Patras A, Brunton NP, O’Donnell C, Tiwari BK (2010) Effect of thermal processing on anthocyanin stability in foods; mechanisms and kinetics of degradation. Trends Food Sci Technol 21:3–11
Peri L, Pietraforte D, Scorza G, Napolitano A, Fogliano V, Minetti M (2005) Apples increase nitric oxide production by human saliva at the acidic pH of the stomach: a new biological function for polyphenols with a catechol group? Free Radic Biol Med 39:668–681
Roth S, Spalinger MR, Gottier C, Biedermann L, Zeitz J, Lang S, Weber A, Rogler G, Scharl M (2016) Bilberry-derived anthocyanins modulate cytokine expression in the intestine of patients with ulcerative colitis. PLoS One 11:e0154817
Sun J, Bai W, Zhang Y, Liao X, Hu X (2011) Identification of degradation pathways and products of cyanidin-3-sophoroside exposed to pulsed electric field. Food Chem 126:1203–1210
Talavéra S, Felgines C, Texier O, Besson C, Lamaison JL, Rémésy C (2003) Anthocyanins are efficiently absorbed from the stomach in anesthetized rats. J Nutr 133:4178–4182
Tian L, Tan Y, Chen G, Wang G, Sun J, Ou S, Chen W, Bai W (2018) Metabolism of anthocyanins and consequent effects on the gut microbiota. Crit Rev Food Sci Nutr. 59(6):982–991
Vendrame S, Klimiszacas D (2015) Anti-inflammatory effect of anthocyanins via modulation of nuclear factor-κB and mitogen-activated protein kinase signaling cascades. Nutr Rev 73:348
Wang L-S, Hecht SS, Carmella SG, Yu N, Larue B, Henry C, McLntyre C, Rocha C, Lechner JF, Stoner GD (2009) Anthocyanins in black raspberries prevent esophageal tumors in rats. Cancer Prev Res 2:84–93
Watson AW, Haskell-Ramsay CF, Kennedy DO, Cooney JM, Trower T, Scheepens A (2015) Acute supplementation with blackcurrant extracts modulates cognitive functioning and inhibits monoamine oxidase-B in healthy young adults. J Funct Foods 17:524–539
Wu X, Beecher GR, Holden JM, Haytowitz DB, Gebhardt SE, Prior RL (2006) Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption. J Agric Food Chem 54:4069–4075
Wu T, Tang Q, Gao Z, Yu Z, Song H, Zheng X, Chen W (2013) Blueberry and mulberry juice prevent obesity development in C57BL/6 mice. PLoS One. 8(10):e77585
Xu H, Luo J, Huang J, Wen Q (2018) Flavonoids intake and risk of type 2 diabetes mellitus: a meta-analysis of prospective cohort studies. Medicine 97:e0686
Yang Z, Chen Z, Yuan S, Zhai W, Piao X, Piao X (2009) Extraction and identification of anthocyanin from purple corn (Zea mays L.). Int J Food Sci Technol 44:2485–2492
Zhang Y, Zeng XG, Jin SK (2012) Autophagy in adipose tissue biology. Pharmacol Res 66:505–512
Zhu Y, Ling W, Guo H, Song F, Ye Q, Zou T, Li D, Zhang Y, Li G, Xiao Y, Liu F, Li Z, Shi Z, Yang Y (2013) Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: a randomized controlled trial. Nutr Metab Cardiovasc Dis 23:843–849
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Jiang, X., Sun, J., Bai, W. (2020). Anthocyanins in Food. In: Xiao, J., Sarker, S., Asakawa, Y. (eds) Handbook of Dietary Phytochemicals. Springer, Singapore. https://doi.org/10.1007/978-981-13-1745-3_13-1
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DOI: https://doi.org/10.1007/978-981-13-1745-3_13-1
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