Abstract
Light, i.e., optical radiation, is mainly used as ultraviolet radiation in dermatotherapy. The most important therapeutic modalities include irradiation with UV-B (280–320 nm) or narrow spectrum UV-B (311–313 nm), UV-A (320–400 nm) or UV-A1 (340–400 nm) as well as the combination of a photosensitizer (mostly psoralens) with UV-A radiation in photochemotherapy. In this chapter, these procedures are explained and indications, dosage recommendations, and risks are described.
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Herzinger T, Berneburg M, Ghoreschi K et al (2016) S1-Leitlinie zur UV-Phototherapie und Photochemotherapie. J Dtsch Dermatol Ges 14:853–862
Kerscher M, Volkenandt M, Plewig G, Lehmann P (1993) Combination phototherapy of psoriasis with calcipotriol and narrow-band UVB. Lancet 342:923
Menter A, Korman NJ, Elmets CA (2010) Guidelines of care for the management of psoriasis and psoriatic arthritis. Section 5 Guidelines of care for the treatment of psoriasis with phototherapy and photochemotherapy. J Am Acad Dermatol 62:114–135
Nast A, Boehncke WH, Mrowietz U, Ockenfels HM, Philipp S, Reich K, Rosenbach T, Sammain A, Schlaeger M, Sebastian M, Sterry W, Streit V, Augustin M, Erdmann R, Klaus J, Koza J, Muller S, Orzechowski HD, Rosumeck S, Schmid-Ott G, Weberstock T, Rzany B (2012) S3 – guidelines on the treatment of psoriasis vulgaris (English version). Update. J Dtsch Dermatol Ges 10(Suppl 2):S1–S95
Singer S, Berneburg M (2018) Phototherapy. J Dtsch Dermatol Ges 16:1120–1129
UV-A1 Phototherapy
Krutmann J, Diepgen TL, Luger TA et al (1998) High-dose UVA1 therapy for atopic dermatitis: results of a multicenter trial. J Am Acad Dermatol 38:589–593
Sator PG, Radakovic S, Schulmeister K et al (2009) Medium-dose is more effective than low-dose ultraviolet A1 phototherapy for localized scleroderma as shown by 20-MHz ultrasound assessment. J Am Acad Dermatol 60:786–791
Schmidt T, Abeck D, Boeck K et al (1998) UVA1 irradiation is effective in treatment of chronic vesicular dyshidrotic hand eczema. Acta Derm Venereol (Stockh) 78:318–319
Photochemotherapy
Berneburg M, Herzinger T, Rampf J et al (2013) Efficacy of bath psoralen plus ultraviolet A (PUVA) vs. system PUVA in psoriasis: a prospective, open, randomized, multicentre study. Br J Dermatol 169:704–708
Cox NH, Jones SK, Downey DJ et al (1987) Cutaneous and ocular side effects of oral photochemotherapy; results of an 8-year follow-up study. Br J Dermatol 116:145–152
Hannuksela-Svahn A, Sigurgeirsson B, Pukkala E et al (1999) Trioxsalen bath PUVA did not increase the risk of squamous cell skin carcinoma and cutaneous malignant melanoma in a joint analysis of 944 Swedish and Finnish patients with psoriasis. Br J Dermatol 141:497–501
Henseler T, Wolff K, Hönigsmann H et al (1981) The European PUVA study (EPS) on oral 8-methoxypsoralen photochemotherapy of psoriasis. A cooperative study among 18 European centres. Lancet 1:853–857
Henseler T, Christophers E, Hönigsmann H et al (1987) Skin tumors in the European PUVA study: eight year follow-up of 1643 patients treated with PUVA for psoriasis. J Am Acad Dermatol 16:108–116
Stern RS, Liebman EJ, Vakeva L (1998) Oral psoralen and ultraviolet-A light (PUVA) treatment of psoriasis and persistent risk of nonmelanoma skin cancer. PUVA follow-up study. J Natl Cancer Inst 90:1278–1284
First Describer
Edelson R, Berger C, Gasparro F et al (1987) Treatment of leukemic cutaneous T-cell lymphoma with extracorporeally-photoactivated 8-methoxypsoralen. N Engl J Med 316:297–303
El Mofty AM (1948) A preliminary report on the treatment of leukoderma with Ammi majus Linn. J Egypt Med Assoc 31:651–665
Fischer T, Alsis J (1976) Treatment of psoriasis with methoxypsoralen bath and dysprosium lamps. Acta Derm Venereol (Stockh) 56:383–390
Goeckermann WH (1925) The treatment of psoriasis. Northwest Med 24:229–231
Ingram JT (1953) The approach to psoriasis. Br Med J II:591–594
Krutmann J, Czech W, Diepgen T et al (1992) High-dose UVA1 therapy in the treatment of patients with atopic dermatitis. J Am Acad Dermatol 26:225–230
Mortazawi SA, Oberste-Lehn H (1973) Photosensibilisatoren und ihre therapeutischen Möglichkeiten. 1. Bericht. Z Haut Geschlechtskr 48:1–9
Mutzhas MF, Hölzle E, Hofmann C et al (1981) A new apparatus with high radiation energy between 320–460 nm: physical description and dermatological applications. J Invest Dermatol 76:42–47
Parrish JA, Jaenicke KF (1981) Action spectrum for phototherapy of psoriasis. J Invest Dermatol 76:359–362
Parrish JA, Fitzpatrick TB, Tanenbaum L et al (1974) Photochemotherapy of psoriasis with oral methoxsalen and long wave ultraviolet light. N Engl J Med 291:1207–1211
Van Weelden H, De La Faille HB, Young E et al (1988) A new development in UVB phototherapy of psoriasis. Br J Dermatol 119:11–19
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Hölzle, E., Lehmann, P. (2022). Physical Therapy: Light. In: Plewig, G., French, L., Ruzicka, T., Kaufmann, R., Hertl, M. (eds) Braun-Falco´s Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-63709-8_117
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DOI: https://doi.org/10.1007/978-3-662-63709-8_117
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