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Anesthesia of Experimental Animals

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Drug Discovery and Evaluation: Pharmacological Assays

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Abstract

In biomedical research, experiments should only be done with a conscious animal if it is not possible to do the study in an anesthetized one. Anesthetic conditions should always be chosen to exclude stress, discomfort, and pain for the animal which could have negative influences on the pharmacological results and reproducibility of the data. Therefore, an experimental design causing minimal discomfort to the animal is always preferable. This is important not only for humanitarian reasons but also for good scientific practice.

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References and Further Reading

  • Alpert M, Goldstein D, Triner L (1982) Technique of endotracheal intubation in rats. Lab Anim 32:78–79

    CAS  Google Scholar 

  • Erhard W, Scherer M, Greiner C, Blümel G (1985) Methods of low term anaesthesia in the rat. Z Versuchstierkunde 27:84

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  • Flecknell PA (1996) Laboratory animal anaesthesia (Second Edn.). A Practical Introduction for Research Workers and Technicians. Academic Press, San Diego

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  • Guedel AE (1951) Inhalation anaesthesia. Macmillan, New York

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  • Kohn DF, Wixson SK, White WJ, Benson GJ (1997) Anesthesia and analgesia in laboratory animals. Academic, San Diego

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  • Sawyer DC (1983) The practice of small animal anaesthesia. W.B. Saunders, Philadelphia

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  • Van Pelt LF (1977) Ketamine and Xylazine for surgical anaesthesia in rats. J Am Vet Med Assoc 171:842–844

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Sanofi-Aventis Deutschland GmbH, Industriepark Hoechst, Building H 821, 65926, Frankfurt, Germany

    Andreas W. Herling

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  1. Andreas W. Herling
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Correspondence to Andreas W. Herling .

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Editors and Affiliations

  1. Dieburg, Germany

    Franz J. Hock

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© 2014 Springer-Verlag Berlin Heidelberg

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Herling, A.W. (2014). Anesthesia of Experimental Animals. In: Hock, F. (eds) Drug Discovery and Evaluation: Pharmacological Assays. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27728-3_133-1

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  • DOI: https://doi.org/10.1007/978-3-642-27728-3_133-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27728-3

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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