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Generic Name
Zaleplon
Brand Name
Sonata
Class
Non-benzodiazepine sedative/hypnotic
Proposed Mechanism(s) of Action
Binds to a subtype of the benzodiazepine receptor (alpha 1), appears to enhance GABA’s inhibitory activity, and increases chloride channel conductance (thus allowing for cellular hyperpolarization)
Indication
Insomnia
Off-Label Use
No common off-label use
Side Effects
Serious
Respiratory depression and rare angioedema
Common
Sedation, ataxia, dizziness, potential amnesia, hallucinations (rare), and headache
References and Readings
Physicians’ desk reference (71st ed.) (2017). Montvale, NJ: Thomson PDR.
Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.
Additional Information
Drug Interaction Effects. http://www.drugs.com/drug_interactions.html
Drug Molecule Images. http://www.worldofmolecules.com/drugs/
Free Drug Online and PDA Software. www.epocrates.com
Free Drug Online and PDA Software. www.medscape.com
Gene-Based Estimate of Drug interactions. http://mhc.daytondcs.com:8080/cgi-bin/ddiD4?ver=4&task=getDrugList
Pill Identification. http://www.drugs.com/pill_identification.html
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© 2018 Springer International Publishing AG, part of Springer Nature
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Courtney, J.C., Gonzalez, E.A. (2018). Zaleplon. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_1723
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DOI: https://doi.org/10.1007/978-3-319-57111-9_1723
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Publisher Name: Springer, Cham
Print ISBN: 978-3-319-57110-2
Online ISBN: 978-3-319-57111-9
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