Abstract
Tissue engineering and regenerative medicine therapies require understanding how molecules and cells coordinate together to influence system level behavior. A key obstacle to advancing our understanding of physiological systems is the inability to probe the specific component-level effects when biological experiments fall short of providing the necessary spatial and temporal resolution over the time course of a response. Hence, a critical question emerges: How can we gain new views not possible with in vivo experiments? The objective of this chapter will be to highlight the impact of biomimetic models, including in vitro, ex vivo, and computational approaches for advancing our understanding of the cellular dynamics involved in microvascular remodeling, which is needed for engineering thick tissues and a common denominator for many pathologies. This overview emphasizes the multiscale cellular complexity of microvascular growth and provides examples of integrative models that offer novel perspectives.
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Dolan, R.M. et al. (2021). Biomimetic Models of the Microcirculation for Scientific Discovery and Therapeutic Testing. In: Holnthoner, W., Banfi, A., Kirkpatrick, J., Redl, H. (eds) Vascularization for Tissue Engineering and Regenerative Medicine. Reference Series in Biomedical Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-319-54586-8_22
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