Abstract
Integration of phage DNA with a bacterial chromosome is not the only form of lysogeny. There is a growing number of reports concerning prophages that exist in cells as plasmids. A large prophage P1 is their best known example. Its evolutionary success appears to result from efficient mechanisms that prevent its loss from a cell, a complex regulatory circuitry of its genes that allow it to quickly respond to changes in host metabolism and from benefits to cells that carry it. Additionally the wide host-range of phage and prophage P1 contributes to the spread of P1 prophage and its relatives among numerous enterobacterial genera, making them effective vectors of horizontal gene transfer that participate in the acquisition of antibiotic resistance genes by their hosts.
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References
Bertani G (1951) Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. J Bacteriol 62:293–300
Billard-Pomares T, Fouteau S, Jacquet ME, Roche D, Barbe V, Castellanos M, Bouet JY, Cruveiller S, Medigue C, Blanco J, Clermont O, Denamur E, Branger C (2014) Characterization of a P1-like bacteriophage carrying an SHV-2 extended-spectrum β-lactamase from an Escherichia coli strain. Antimicrob Agents Chemother 58:6550–6557
Branger C, Ledda A, Billard-Pomares T et al (2018) Extended-spectrum β-lactamase-encoding genes are spreading on a wide range of Escherichia coli plasmids existing prior to the use of third-generation cephalosporins. Microb Genom 4(9):e000203. https://doi.org/10.1099/mgen.0.000203
Brendler T, Abeles A, Austin S (1995) A protein that binds to the P1 origin core and the oriC 13mer region in a methylation-specific fashion is the product of the host seqA gene. EMBO J 14:4083–4089
Chattoraj DK (2000) Control of plasmid DNA replication by iterons: no longer paradoxical. Mol Microbiol 37:467–476
Citron M, Schuster H (1990) The c4 repressors of bacteriophages P1 and P7 are antisense RNAs. Cell 62:591–598
Cruz JW, Rothenbacher FP, Maehigashi T, Lane WS, Dunham CM, Woychik NA (2014) Doc toxin is a kinase that inactivates elongation factor Tu. J Biol Chem 289:7788–7798
Devlin BH, Baumstark BR, Scott JR (1982) Superimmunity: characterization of a new gene in the immunity region of P1. Virology 120:360–375
Funnell BE, Slavcev RA (2004) Partition systems of bacterial plasmids. In: Funnell BE, Phillips GJ (eds) Plasmid biology. ASM Press, Washington, DC, pp 81–104
Giermasińska K, Łobocka M (2016) Interaction of bacteriophage P1 with cells of selected plant pathogens of the genus Erwinia and related genera. In: Zdunek B, Olszówka M (eds) Selected issues of chemistry, physics and biology. Tygiel Press, Lublin, Poland, pp 48–67. ISBN 978-83-65598-37-0
Gruenig MC, Lu D, Won SJ, Dulberger CL, Manlick AJ, Keck JL, Cox MM (2011) Creating directed double-strand breaks with the Ref protein: a novel RecA-dependent nuclease from bacteriophage P1. J Biol Chem 286:8240–8251
Hagbø M, Ravi A, Angell IL, Sunde M, Ludvigsen J, Diep DB, Foley SL, Vento M, Collado MC, Perez-Martinez G, Rudi K (2020) Experimental support for multidrug resistance transfer potential in the preterm infant gut microbiota. Pediatr Res 88:57–65
Hammerl JA, Klevanskaa K, Strauch E, Hertwig S (2014) Complete nucleotide sequence of pVv01, a P1-Like Plasmid Prophage of Vibrio vulnificus. Genome Announc 2:e00135–e00114
Hansen AM, Lehnherr H, Wang X, Mobley V, Jin DJ (2003) Escherichia coli SspA is a transcription activator for bacteriophage P1 late genes. Mol Microbiol 48:1621–1631
Hazan R, Sat B, Reches M, Engelberg-Kulka H (2001) Postsegregational killing mediated by the P1 phage “addiction module” phd-doc requires the Escherichia coli programmed cell death system mazEF. J Bacteriol 183:2046–2050
Kaiser D, Dworkin M (1975) Gene transfer to myxobacterium by Escherichia coli phage P1. Science 187:653–654
Kim SY, Ko KS (2019) Diverse plasmids harboring blaCTX-M-15 in Klebsiella pneumoniae ST11 isolates from several Asian countries. Microb Drug Resist 25:227–232
Lehnherr H (2006) Bacteriophage P1. In: Calender R (ed) The bacteriophages. Oxford University Press, New York, pp 350–364
Lehnherr H, Yarmolinsky MB (1995) Addiction protein Phd of plasmid prophage P1 is a substrate of the ClpXP serine protease of Escherichia coli. Proc Natl Acad Sci USA 92:3274–3277
Lehnherr H, Maguin E, Jafri S, Yarmolinsky MB (1993) Plasmid addiction genes of bacteriophage P1: doc, which causes cell death on curing of prophage, and phd, which prevents host death when prophage is retained. J Mol Biol 233:414–428
Łobocka M, Yarmolinsky M (1996) P1 plasmid partition: a mutational analysis of ParB. J Mol Biol 259:366–382
Łobocka M, Rose DJ, Plunkett G, Rusin M, Samojedny A, Lehnherr H, Yermolinsky MB, Blattner FR (2004) Genome of bacterophage P1. J Bacteriol 186:7032–7068
Magnuson R, Yarmolinsky MB (1998) Corepression of the P1 addiction operon by Phd and Doc. J Bacteriol 186:6342–6351
Magnuson R, Lehnherr H, Mukhopadhyay G, Yarmolinsky MB (1996) Autoregulation of the plasmid addiction operon of bacteriophage P1. J Biol Chem 271:18705–18710
Makarova KS, Wolf YI, Koonin EV (2009) Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. Biol Direct 4:19
McLenigan MP, Kulaeva OI, Ennis DG, Levine AS, Woodgate R (1999) The bacteriophage P1 HumD protein is a functional homolog of the prokaryotic UmuD’-like proteins and facilitates SOS mutagenesis in Escherichia coli. J Bacteriol 181:7005–7013
Oladeinde A, Cook K, Lakin SM, Woyda R, Abdo Z, Looft T, Herrington K, Zock G, Lawrence JP, Thomas JC 4th, Beaudry MS, Glenn T (2019) Horizontal gene transfer and acquired antibiotic resistance in Salmonella enterica serovar Heidelberg following in vitro incubation in broiler ceca. Appl Environ Microbiol 85:e01903–e01919
Rodionov O, Lobocka M, Yarmolinsky M (1999) Silencing of genes flanking the P1 plasmid centromere. Science 283:546–549
Rosner JL (1972) Formation, induction, and curing of bacteriophage P1 lysogens. Virology 48:679–689
Shin J, Ko KS (2015) A plasmid bearing the bla(CTX-M-15) gene and phage P1-like sequences from a sequence Type 11 Klebsiella pneumoniae isolate. Antimicrob Agents Chemother 59:6608–6610
Venturini C, Zingali T, Wyrsch ER, Bowring B, Iredell J, Partridge SR, Djordjevic SP (2019) Diversity of P1 phage-like elements in multidrug resistant Escherichia coli. Sci Rep 9:18861
Walker DH, Anderson TF (1970) Morphological variants of coliphage P1. J Virol 5:765–782
Williams MD, Fuchs JA, Flickinger MC (1991) Null mutation in the stringent starvation protein of Escherichia coli disrupts lytic development of bacteriophage P1. Gene 109:21–30
Yang L, Li W, Jiang GZ, Zhang WH, Ding HZ, Liu YH, Zeng ZL, Jiang HX (2017) Characterization of a P1-like bacteriophage carrying CTX-M-27 in Salmonella spp. resistant to third generation cephalosporins isolated from pork in China. Sci Rep 7:40710
Yarmolinsky MB (2004) Bacteriophage P1 in retrospect and in prospect. J Bacteriol 186:7025–7028
Yarmolinsky M, Hoess R (2015) The legacy of Nat Sternberg: the genesis of Cre-lox technology. Annu Rev Virol 2:25–40
Yarmolinsky M, Sternberg N (1988) Bacteriophage Pl. In: Calendar R (ed) The bacteriophages, vol 1. Plenum Press, New York, pp 291–438
Zeph LR, Onaga MA, Stotzky G (1988) Transduction of Escherichia coli by bacteriophage P1 in soil. Appl Environ Microbiol 54:1731–1737
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This work was supported by the statutory funds for the Institute of Biochemistry and Biophysics of the Polish Academy of Sciences.
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Łobocka, M., Gągała, U. (2021). Prophage P1: An Example of a Prophage That Is Maintained as a Plasmid. In: Harper, D.R., Abedon, S.T., Burrowes, B.H., McConville, M.L. (eds) Bacteriophages. Springer, Cham. https://doi.org/10.1007/978-3-319-40598-8_54-1
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DOI: https://doi.org/10.1007/978-3-319-40598-8_54-1
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