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Trauma Products: Spinal Cord Injury Implants

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Handbook of Spine Technology

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Abstract

The incidence of acute traumatic spinal cord injury (SCI) in the USA is approximately 27–81 cases per million people per year with cervical SCI being the most common site of injury. Despite early surgical decompression, secondary injury and the cascade of effects in the ensuing days and months remain one of the biggest barriers in achieving recovery in these patients. A host of pharmacologic, cellular, immunomodulatory, and rehabilitative interventions have been employed over the past several decades in an attempt to improve functional outcome in this population. Though no single intervention is likely to provide a cure, important information has been gained about the heterogeneity of this population and the myriad physiological processes underlying the acute and chronic phases of injury. Herein, we provide a broad overview of the underlying pathophysiology, discuss various cellular, structural, and pharmacologic therapies tested, and address the challenges and insights gained from completed SCI trials.

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Authors and Affiliations

  1. Department of Neurological Surgery, University of California Irvine, Orange, CA, USA

    Gilbert Cadena Jr., Jordan Xu & Angie Zhang

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  1. Gilbert Cadena Jr.
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  2. Jordan Xu
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  3. Angie Zhang
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Correspondence to Gilbert Cadena Jr. .

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Editors and Affiliations

  1. Department of Neurosurgery, Allegheny General Hospital Department of Neurosurgery, Mars, PA, USA

    Boyle Cheng

Section Editor information

  1. Center for Spine Health, S40 Cleveland Clinic, Cleveland, OH, USA

    R. Douglas Orr

  2. Department of Neurosurgery + Academic Services, Allegheny Health Network, Pittsburgh, PA, USA

    Michael Y. Oh

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Cadena, G., Xu, J., Zhang, A. (2020). Trauma Products: Spinal Cord Injury Implants. In: Cheng, B. (eds) Handbook of Spine Technology. Springer, Cham. https://doi.org/10.1007/978-3-319-33037-2_48-1

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  • DOI: https://doi.org/10.1007/978-3-319-33037-2_48-1

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  • Print ISBN: 978-3-319-33037-2

  • Online ISBN: 978-3-319-33037-2

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