Abstract
Worldwide, chronic obstructive pulmonary disease, asthma, lung cancer, and cystic fibrosis are some of the top causes of death and morbidity. As a result, these illnesses place a significant burden on healthcare systems, economies, and societies in many nations. Chronic respiratory illnesses impact the respiratory airways, lung parenchyma, and pulmonary vasculature, among other parts of the respiratory system. Respiratory disorders are a fairly frequent diagnosis in children, adolescents, and adults in the era of air pollution. Both upper and lower respiratory system disorders can have a significant negative impact on overall health as well as economic and psychological burdens. Because they are eco-friendly and have few side effects, plant-based solutions are receiving a lot of attention as a means of treating and preventing health issues. It is believed that active plant contact and exposure to nature are good for both physical and mental health. The immunological and cardiovascular systems are the main targets of plant-based medications. The medicinal properties of both terrestrial and marine botanicals are an effective control of a variety of disorders. Biologically active compounds with distinct values may be isolated from both. Therefore, the main aim of this chapter is to know the potential of pulmonary diseases and to provide the knowledge of plant therapy or some medicinal herbs for curing.
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Abbreviations
- AYUSH:
-
Ayurveda, Yoga and Naturopathy, Unani, Siddha, and Homeopathy
- ACE2 :
-
Angiotensin-converting enzyme
- AKT :
-
Ak strain transforming
- BAX:
-
Bcl-2-associated X protein
- CD :
-
Cluster of differentiation
- CDK:
-
Cyclin-dependent kinases
- COPD:
-
Chronic obstructive pulmonary disease
- COVID-19:
-
Corona virus disease – 2019
- CXCR4:
-
C-X-C motif chemokine receptor 4
- DMDS:
-
Dimethyl disulphide
- ET:
-
Endotracheal Tube
- FEV:
-
Forced expiratory volume
- GSH:
-
Glutathione
- HIV:
-
Human immunodeficiency virus
- HUVEC:
-
Human umbilical vein endothelial cells
- LOX:
-
Lipoxygenase
- MCT:
-
Medium chain triglycerides
- MDA :
-
Malondialdehyde
- NOS :
-
Nitric oxide synthase
- PAP:
-
Pulmonary artery pressure
- PASMC :
-
Pulmonary artery smooth muscle cells
- PDE:
-
Phosphodiesterase enzyme
- RNA:
-
Ribonucleic acid
- ROS:
-
Reactive oxygen species
- RVH:
-
Right ventricular hypertrophy
- RVSP:
-
Right Ventricular Systolic Pressure
- SARS CoV-2:
-
Severe acute respiratory syndrome coronavirus 2
- SOD:
-
Superoxide dismutases
- TGF:
-
Transforming growth factor
- TMS :
-
Transcranial magnetic stimulation
- VEGF:
-
Vascular endothelial growth factor
- WBC:
-
White blood cells
References
Cheeke P (2009) Applications of saponins as feed additives in poultry production. In: Proceedings of the 20th Australian poultry science symposium, Sydney, Australia, p 50, December
Dagli N, Dagli R, Mahmoud RS, Baroudi K (2015) Essential oils, their therapeutic properties, and implication in dentistry: a review. J Int Soc Prev Community Dent 5(5):335
Kumar M, Changan S, Tomar M, Prajapati U, Saurabh V, Hasan M et al (2021) Custard apple (Annona squamosa L.) leaves: nutritional composition, phytochemical profile, and health-promoting biological activities. Biomol Ther 11(5):614
Jasemi SV, Khazaei H, Aneva IY, Farzaei MH, Echeverría J (2020) Medicinal plants and phytochemicals for the treatment of pulmonary hypertension. Front Pharmacol 11:145
Lee MS, Lee J, Park BJ, Miyazaki Y (2015) Interaction with indoor plants may reduce psychological and physiological stress by suppressing autonomic nervous system activity in young adults: a randomized crossover study. J Physiol Anthropol 34(1):1–6
Bringslimark T, Hartig T, Patil GG (2009) The psychological benefits of indoor plants: a critical review of the experimental literature. J Environ Psychol 29(4):422–433
Jiang B, Li D, Larsen L, Sullivan WC (2016) A dose-response curve describing the relationship between urban tree cover density and self-reported stress recovery. Environ Behav 48(4):607–629
Jiang B, Larsen L, Deal B, Sullivan WC (2015) A dose–response curve describing the relationship between tree cover density and landscape preference. Landsc Urban Plan 139:16–25
Dela Cruz M, Christensen JH, Thomsen JD, Müller R (2014) Can ornamental potted plants remove volatile organic compounds from indoor air? – a review. Environ Sci Pollut Res 21:13909–13928
Kim KJ, Jeong MI, Lee DW, Song JS, Kim HD, Yoo EH et al (2010) Variation in formaldehyde removal efficiency among indoor plant species. HortScience 45(10):1489–1495
Yang DS, Pennisi SV, Son KC, Kays SJ (2009) Screening indoor plants for volatile organic pollutant removal efficiency. HortScience 44(5):1377–1381
Janhäll S (2015) Review on urban vegetation and particle air pollution–deposition and dispersion. Atmos Environ 105:130–137
Shepherd D, Welch D, Dirks KN, McBride D (2013) Do quiet areas afford greater health-related quality of life than noisy areas? Int J Environ Res Public Health 10(4):1284–1303
Van Renterghem T, Forssén J, Attenborough K, Jean P, Defrance J, Hornikx M, Kang J (2015) Using natural means to reduce surface transport noise during propagation outdoors. Appl Acoust 92:86–101
Coccolo S, Pearlmutter D, Kaempf J, Scartezzini JL (2018) Thermal comfort maps to estimate the impact of urban greening on the outdoor human comfort. Urban For Urban Green 35:91–105
Rawal G, Yadav S, Kumar R (2018) Acute respiratory distress syndrome: an update and review. J Transl Intern Med 6(2):74–77
Confalonieri M, Salton F, Fabiano F (2017) Acute respiratory distress syndrome. Eur Respir Rev 26(144):160116
Chalmers JD (2017) Management of chronic airway diseases: what can we learn from real-life data? COPD: J Chron Obstruct Pulmon Dis 14(sup1):S1–S2
Alsuhaibani S, Khan MA (2017) Immune-stimulatory and therapeutic activity of Tinospora cordifolia: double-edged sword against salmonellosis. J Immunol Res 2017:1787803
Bhalla G, Kaur S, Kaur J, Kaur R, Raina P (2017) Antileishmanial and immunomodulatory potential of Ocimum sanctum Linn. and Cocos nucifera Linn. in murine visceral leishmaniasis. J Parasit Dis 41:76–85
Patgiri B, Umretia BL, Vaishnav PU, Prajapati PK, Shukla VJ, Ravishankar B (2014) Anti-inflammatory activity of Guduchi Ghana (aqueous extract of Tinospora Cordifolia Miers.). Ayu 35(1):108
More P, Pai K (2011) Immunomodulatory effects of Tinospora cordifolia (Guduchi) on macrophage activation. Biol Med 3(2):134–140
Kumar S, Kamboj J, Sharma S (2011) Overview for various aspects of the health benefits of Piper longum linn. fruit. J Acupunct Meridian Stud 4(2):134–140
Lampariello LR, Cortelazzo A, Guerranti R, Sticozzi C, Valacchi G (2012) The magic velvet bean of Mucuna pruriens. J Tradit Complement Med 2(4):331–339
Jiang ZY, Liu WF, Zhang XM, Luo J, Ma YB, Chen JJ (2013) Anti-HBV active constituents from Piper longum. Bioorg Med Chem Lett 23(7):2123–2127
Cohen MM (2014) Tulsi-Ocimum sanctum: a herb for all reasons. J Ayurveda Integr Med 5(4):251
Patil GG, Mali PY, Bhadane VV (2008) Folk remedies used against respiratory disorders in Jalgaon district, Maharashtra. Indian J Nat Prod Resour 7(4):354–358
Kyokong O, Charuluxananan S, Muangmingsuk V, Rodanant O, Subornsug K, Punyasang W (2002) Efficacy of chamomile-extract spray for prevention of post-operative sore throat. J Med Assoc Thai 85:S180–S185
Roy P, Abdulsalam FI, Pandey DK, Bhattacharjee A, Eruvaram NR, Malik T (2015) Evaluation of antioxidant, antibacterial, and antidiabetic potential of two traditional medicinal plants of India: Swertia cordata and Swertia chirayita. Pharm Res 7(5s):S57–S62
Singh KP, Upadhyay B, Pra R, Kumar A (2010) Screening of Adhatoda vasica Nees as a putative HIV-protease inhibitor. J Phytology 2(4):78–82
Balkrishna A, Pokhrel S, Singh J, Varshney A (2020) Withanone from Withania somnifera may inhibit novel coronavirus (COVID-19) entry by disrupting interactions between viral S-protein receptor binding domain and host ACE2 receptor. https://doi.org/10.21203/rs.3.rs-17806/v1
Horníčková J, Kubec R, Cejpek K, Velíšek J, Ovesná J, Stavělíková H (2010) Profiles of S-alk (en) ylcysteine sulfoxides in various garlic genotypes. Czech J Food Sci 28(4):298–308
Lanzotti V, Scala F, Bonanomi G (2014) Compounds from allium species with cytotoxic and antimicrobial activity. Phytochem Rev 13:769–791
Bhuiyan FR, Howlader S, Raihan T, Hasan M (2020) Plants metabolites: possibility of natural therapeutics against the COVID-19 pandemic. Front Med 7:444
Chu CC, Wu WS, Shieh JP, Chu HL, Lee CP, Duh PD (2017) The anti-inflammatory and vasodilating effects of three selected dietary organic sulfur compounds from allium species. J Funct Biomater 8(1):5
Sobolewska D, Podolak I, Makowska-Wąs J (2015) Allium ursinum: botanical, phytochemical and pharmacological overview. Phytochem Rev 14:81–97
Oszmianski J, Kolniak-Ostek J, Wojdyło A (2013) Characterization and content of flavonol derivatives of Allium ursinum L. plant. J Agric Food Chem 61(1):176–184
Lines TC, Ono M (2006) FRS 1000, an extract of red onion peel, strongly inhibits phosphodiesterase 5A (PDE 5A). Phytomedicine 13(4):236–239
Kass DA, Champion HC, Beavo JA (2007) Phosphodiesterase type 5: expanding roles in cardiovascular regulation. Circ Res 101(11):1084–1095
Bombicz M, Priksz D, Varga B, Kurucz A, Kertész A, Takacs A et al (2017) A novel therapeutic approach in the treatment of pulmonary arterial hypertension: Allium ursinum liophylisate alleviates symptoms comparably to sildenafil. Int J Mol Sci 18(7):1436
Rosado-Vallado M, Brito-Loeza W, Mena-Rejon GJ, Quintero-Marmol E, Flores-Guido JS (2000) Antimicrobial activity of Fabaceae species used in Yucatan traditional medicine. Fitoterapia 71(5):570–573
Welsh D, Mortimer H, Kirk A, Peacock A (2005) The role of p38 mitogen-activated protein kinase in hypoxia-induced vascular cell proliferation: an interspecies comparison. Chest 128(6):573S–574S
Bouea SM, Wiese TE, Nehls S, Burow ME, Elliott S, Carter-Wientjes CH, Shih BY, Mclachlan JA, Cleveland TE (2003) Evaluation of the estrogenic effects of legume extracts containing phytoestrogens. J Agric Food Chem 51:2193–2199
Wang LD, Qiu XQ, Tian ZF, Zhang YF, Li HF (2008) Inhibitory effects of genistein and resveratrol on Guinea pig gallbladder contractility in vitro. World J Gastroenterol: WJG 14(31):4955
Tan X, Chai J, Bi SC, Li JJ, Li WW, Zhou JY (2012) Involvement of matrix metalloproteinase-2 in medial hypertrophy of pulmonary arterioles in broiler chickens with pulmonary arterial hypertension. Vet J 193(2):420–425
Simoncini T, Fornari L, Mannella P, Caruso A, Garibaldi S, Baldacci C, Genazzani AR (2005) Activation of nitric oxide synthesis in human endothelial cells by red clover extracts. Menopause 12(1):69–77
Gruenwald J, Graubaum HJ, Busch R (2005) Efficacy and tolerability of a fixed combination of thyme and primrose root in patients with acute bronchitis. Arzneimittelforschung 55(11):669–676
Guo R, Pittler MH, Ernst E (2006) Herbal medicines for the treatment of COPD: a systematic review. Eur Respir J 28(2):330–338
Wienkötter N, Höpner D, Schütte U, Bauer K, Begrow F, El-Dakhakhny M, Verspohl EJ (2008) The effect of nigellone and thymoquinone on inhibiting trachea contraction and mucociliary clearance. Planta Med 74(02):105–108
Singh RP, Banerjee S, Rao AR (2001) Modulatory influence of Andrographis paniculata on mouse hepatic and extrahepatic carcinogen metabolizing enzymes and antioxidant status. Phytother Res 15(5):382–390
Huang ST, Yang RC, Lee PN, Yang SH, Liao SK, Chen TY, Pang JHS (2006) Anti-tumor and anti-angiogenic effects of Phyllanthus urinaria in mice bearing Lewis lung carcinoma. Int Immunopharmacol 6(6):870–879
Garodia P, Ichikawa H, Malani N, Sethi G, Aggarwal BB (2007) From ancient medicine to modern medicine: ayurvedic concepts of health and their role in inflammation and cancer. J Soc Integr Oncol 5(1):25–37
Prakash PAGN, Gupta N (2005) Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: a short review. Indian J Physiol Pharmacol 49(2):125
Kurashima K, Takaku Y, Ohta C, Takayanagi N, Yanagisawa T, Kanauchi T, Takahashi O (2017) Smoking history and emphysema in asthma–COPD overlap. Int J Chron Obstruct Pulmon Dis 12:3523–3532
Temkitthawon P, Changwichit K, Khorana N, Viyoch J, Suwanborirux K, Ingkaninan K (2017) Phenanthrenes from Eulophia macrobulbon as novel phosphodiesterase-5 inhibitors. Nat Prod Commun 12(1):1934578X1701200121
Wisutthathum S, Demougeot C, Totoson P, Adthapanyawanich K, Ingkaninan K, Temkitthawon P, Chootip K (2018) Eulophia macrobulbon extract relaxes rat isolated pulmonary artery and protects against monocrotaline-induced pulmonary arterial hypertension. Phytomedicine 50:157–165
Espley RV, Butts CA, Laing WA, Martell S, Smith H, McGhie TK et al (2014) Dietary flavonoids from modified apple reduce inflammation markers and modulate gut microbiota in mice. J Nutr 144(2):146–154
Hua C, Zhao J, Wang H, Chen F, Meng H, Chen L et al (2018) Apple polyphenol relieves hypoxia-induced pulmonary arterial hypertension via pulmonary endothelium protection and smooth muscle relaxation: in vivo and in vitro studies. Biomed Pharmacother 107:937–944
Dong MS, Jung SH, Kim HJ, Kim JR, Zhao LX, Lee ES et al (2004) Structure-related cytotoxicity and anti-hepatofibric effect of asiatic acid derivatives in rat hepatic stellate cell-line, HSC-T6. Arch Pharm Res 27:512–517
Wang X, Cai X, Wang W, Jin Y, Chen M, Huang X et al (2018) Effect of asiaticoside on endothelial cells in hypoxia-induced pulmonary hypertension. Mol Med Rep 17(2):2893–2900
Wang XB, Wang W, Zhu XC, Ye WJ, Cai H, Wu PL et al (2015) The potential of asiaticoside for TGF-β1/Smad signaling inhibition in prevention and progression of hypoxia-induced pulmonary hypertension. Life Sci 137:56–64
Auyeung KK, Han QB, Ko JK (2016) Astragalus membranaceus: a review of its protection against inflammation and gastrointestinal cancers. Am J Chin Med 44(01):1–22
Li G, Gai X, Li Z, Chang R, Qi Y, Zhaxi D et al (2016) Preliminary study of active component and mechanism of Rhodiola algida var. tangutica on inducing rat pulmonary artery vasorelaxation. J Qin Med Coll 1:40–45
Li HX, Sze SCW, Tong Y, Ng TB (2009) Production of Th1-and Th2-dependent cytokines induced by the Chinese medicine herb, Rhodiola algida, on human peripheral blood monocytes. J Ethnopharmacol 123(2):257–266
Nan X, Su S, Ma K, Ma X, Wang X, Zhaxi D et al (2018) Bioactive fraction of Rhodiola algida against chronic hypoxia-induced pulmonary arterial hypertension and its anti-proliferation mechanism in rats. J Ethnopharmacol 216:175–183
Mohanty IR, Arya DS, Gupta SK (2008) Withania somnifera provides cardioprotection and attenuates ischemia–reperfusion induced apoptosis. Clin Nutr 27(4):635–642
Ojha SK, Arya DS (2009) Withania somnifera Dunal (Ashwagandha): a promising remedy for cardiovascular diseases. World J Med Sci 4(2):156–158
Ichikawa H, Takada Y, Shishodia S, Jayaprakasam B, Nair MG, Aggarwal BB (2006) Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-κB (NF-κB) activation and NF-κB–regulated gene expression. Mol Cancer Ther 5(6):1434–1445
Occhiuto F, Limardi F (1994) Comparative effects of the flavonoids luteolin, apiin and rhoifolin on experimental pulmonary hypertension in the dog. Phytother Res 8(3):153–156
Yeung AWK, Tzvetkov NT, Balacheva AA, Georgieva MG, Gan RY, Jozwik A et al (2020) Lignans: quantitative analysis of the research literature. Front Pharmacol 11:37
Testa JR, Bellacosa A (2001) AKT plays a central role in tumorigenesis. Proc Natl Acad Sci 98(20):10983–10985
Guan Z, Shen L, Liang H, Yu H, Hei B, Meng X, Yang L (2017) Resveratrol inhibits hypoxia-induced proliferation and migration of pulmonary artery vascular smooth muscle cells by inhibiting the phosphoinositide 3-kinase/protein kinase B signaling pathway. Mol Med Rep 16(2):1653–1660
Shivakrupa R, Bernstein A, Watring N, Linnekin D (2003) Phosphatidylinositol 3′-kinase is required for growth of mast cells expressing the kit catalytic domain mutant. Cancer Res 63(15):4412–4419
Paffett ML, Lucas SN, Campen MJ (2012) Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: a potential role for atrogin-1 in smooth muscle. Vasc Pharmacol 56(1–2):64–73
Prabhakar NR, Semenza GL (2012) Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiol Rev 92(3):967–1003
Kooti W, Servatyari K, Behzadifar M, Asadi-Samani M, Sadeghi F, Nouri B, Zare Marzouni H (2017) Effective medicinal plant in cancer treatment, part 2: review study. J Evid Based Complementary Altern Med 22(4):982–995
Clarke R, Lundy FT, McGarvey L (2015) Herbal treatment in asthma and COPD–current evidence. Clin Phytoscience 1(1):1–7
Cesca TG, Faqueti LG, Rocha LW, Meira NA, Meyre-Silva C, De Souza MM et al (2012) Antinociceptive, anti-inflammatory and wound healing features in animal models treated with a semisolid herbal medicine based on Aleurites moluccana L. Willd. Euforbiaceae standardized leaf extract: semisolid herbal. J Ethnopharmacol 143(1):355–362
Gholamnezhad Z, Shakeri F, Saadat S, Ghorani V, Boskabady MH (2019) Clinical and experimental effects of Nigella sativa and its constituents on respiratory and allergic disorders. Avicenna J Phytomed 9(3):195
Kumar D, Prasad DN, Parkash J, Bhatnagar SP, Kumar D (2009) Antiasthmatic activity of ethanolic extract of Aerva lanata Linn. Pharmacologyonline 2:1075–1081
Ram A, Balachandar S, Vijayananth P, Singh VP (2011) Medicinal plants useful for treating chronic obstructive pulmonary disease (COPD): current status and future perspectives. Fitoterapia 82(2):141–151
Sharma PK, Johri S, Mehra BL (2010) Efficacy of Vasadi syrup and Shwasaghna Dhuma in the patients of COPD (Shwasa Roga). Ayu 31(1):48
Desai AG, Qazi GN, Ganju RK, El-Tamer M, Singh J, Saxena AK et al (2008) Medicinal plants and cancer chemoprevention. Curr Drug Metab 9(7):581–591
Gupta VK, Kaushik A, Chauhan DS, Ahirwar RK, Sharma S, Bisht D (2018) Anti-mycobacterial activity of some medicinal plants used traditionally by tribes from Madhya Pradesh, India for treating tuberculosis related symptoms. J Ethnopharmacol 227:113–120
Hussain Z, Mohammad P, Sadozai SK, Khan KM, Nawaz Y, Perveen S (2011) Extraction of anti-pneumonia fractions from the leaves of sugar beets Beta vulgaris. J Pharm Res 4(12):4783–4785
Asadbeigi M, Mohammadi T, Rafieian-Kopaei M, Saki K, Bahmani M, Delfan M (2014) Traditional effects of medicinal plants in the treatment of respiratory diseases and disorders: an ethnobotanical study in the Urmia. Asian Pac J Trop Med 7:S364–S368
Girija PLT, Sivan N (2022) Ayurvedic treatment of COVID-19: a case report. J Ayurveda Integr Med 13(1):100329
Kasote DM, Katyare SS, Hegde MV, Bae H (2015) Significance of antioxidant potential of plants and its relevance to therapeutic applications. Int J Biol Sci 11(8):982
Pan SY, Zhou SF, Gao SH, Yu ZL, Zhang SF, Tang MK et al (2013) New perspectives on how to discover drugs from herbal medicines: CAM’s outstanding contribution to modern therapeutics. Evid Based Complementary Altern Med 2013:627375
Pye CR, Bertin MJ, Lokey RS, Gerwick WH, Linington RG (2017) Retrospective analysis of natural products provides insights for future discovery trends. Proc Natl Acad Sci 114(22):5601–5606
Mann J (2002) Natural products in cancer chemotherapy: past, present and future. Nat Rev Cancer 2(2):143–148
Kebaili Z, Hameurlaine S, Fellah O, Djermane M, Gherraf N (2019) Assessment of alkaloid content and antibacterial activity of Hyoscyamus albus and Hyoscyamus muticus collected in two different climatic regions in Algeria. J Biochem Technol 10(1):1
Hanif A, Juahir H, Lananan F, Kamarudin MKA, Adiana G, Azemin A, Yusra AI (2018) Spatial variation of Melaleuca cajuputi powell essential oils. J Fundam Appl Sci 10(1S):139–155
Fellah O, Hameurlaine S, Gherraf N, Zellagui A, Ali T, Abidi A et al (2018) Anti-proliferative activity of ethyl acetate extracts of grown at different climatic conditions in Algeria. Acta Sci Nat 5(2):23–31
Sharrock S, Jones M (2009) Conserving Europe’s threatened plants: progress towards target 8 of the global strategy for plant conservation. BGCI, Richmond
Maridass M, De Britto AJ (2008) Origins of plant derived medicines. Ethnobot Leafl 2008(1):44
Acknowledgment
We would like to extend our sincere appreciation and gratitude to the Department of Agronomy at the School of Agriculture at Lovely Professional University, Punjab, 144411, India.
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Kumar, P., Saini, L., Sharma, M. (2023). Assessment of the Phytochemical Constituents and Metabolites in the Medicinal Plants and Herbal Medicine Used in the Treatment and Management of Respiratory Diseases. In: Izah, S.C., Ogwu, M.C., Akram, M. (eds) Herbal Medicine Phytochemistry. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-031-21973-3_19-1
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