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3D Printed Meniscal Scaffolds

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Orthopaedic Sports Medicine

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Abstract

The meniscus is a fibrocartilaginous tissue found between the femoral condyle and the tibial plateau in the knee. It contributes to the transmission of load, shock absorption, stability, lubrication of the joint, and the overall protection of the articular cartilage, as well as to the proprioception of the knee during movement. Therefore, the meniscus is essential for the healthy function of the knee. Unfortunately, the meniscus is often damaged. Moreover, meniscus injuries may never properly heal due to their segmental vascularization and may therefore require surgical intervention. Modern tissue engineering aims to create meniscal scaffolds, which can replace the meniscus and its functions totally or partially in the short term, before being gradually replaced by newly formed tissue. Many approaches, materials, and techniques have been studied to create meniscal implants. Recently, thanks to the progress of 3D (bio)printing technologies, it has been possible to develop anatomically correct meniscal scaffolds that replicate the complex architecture of the native meniscus. Currently developed meniscal scaffolds are also able to reproduce the biomechanics of native menisci while providing a favorable environment to promote cell differentiation into relevant phenotypes for meniscal extracellular matrix (ECM) deposition. Although further development in 3D structure is still required, recent results involving 3D (bio)printing of meniscal scaffolds have raised the hopes of producing all-encompassing meniscal personalized implants. The recent studies and trends in 3D-printed meniscal scaffolds are overviewed herein.

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Acknowledgments

The authors acknowledge the financial support provided through the projects B-FABULUS (PTDC/BBB-ECT/2690/2014) and Fun4TE (PTDC/EMD-EMD/31367/2017), financed by the Portuguese Foundation for Science and Technology (FCT) and co-financed by European Regional Development Fund (FEDER) and Operational Programme for Competitiveness and Internationalisation (POCI). This work has been co-funded through the 3BioMeD project (FCT/4773/4/5/2017/S). The authors also thank the financial support under the Norte2020 project (NORTE-08-5369-FSE000044) and the FCT program (PD/BD/143081/2018). The authors also thank the funding through the project 2IQBIONEURO (ref. 0624_2IQBIONEURO_6_E). IFC thanks the TERM RES-Hub, Tissue Engineering and Regenerative Medicine Infrastructure project, funded by FCT. G. Decante acknowledges for his research fellowship (BI_PTDC/BBB-ECT/2690/2014_2020_01) attributed under the B-FABULUS project. The FCT distinction attributed to IFC under the Estímulo ao Emprego Científico program (2021.01969.CEECIND) is also greatly acknowledged.

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Authors and Affiliations

  1. 3B’s Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Zona Industrial da Gandra, Barco, Portugal

    Guy Decante, Ibrahim Fatih Cengiz, Joana Silva-Correia, Rui L. Reis & J. Miguel Oliveira

  2. ICVS/3B’s – PT Government Associate Laboratory, Braga, Portugal

    Guy Decante, Ibrahim Fatih Cengiz, Joana Silva-Correia, Rui L. Reis & J. Miguel Oliveira

Authors
  1. Guy Decante
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  2. Ibrahim Fatih Cengiz
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  3. Joana Silva-Correia
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  4. Rui L. Reis
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  5. J. Miguel Oliveira
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Corresponding author

Correspondence to Ibrahim Fatih Cengiz .

Editor information

Editors and Affiliations

  1. Espregueira-Mendes Sports Centre, Clínica do Dragão, Porto, Portugal

    João Espregueira-Mendes

  2. Dept. Orthopaedics, Sahlgrenska University Hospital, Mölndal, Sweden

    Jón Karlsson

  3. UPMC Freddie Fu SportsMed Ctr, Orth Surg, University of Pittsburgh, Pittsburgh, PA, USA

    Volker Musahl

  4. McMaster University, Hamilton, ON, Canada

    Olufemi R. Ayeni

Section Editor information

  1. 3B's Research Group—Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho., Guimarães, Barco, Portugal

    Rui L. Reis

  2. ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal

    Rui L. Reis

  3. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Univ. Minho, Guimarães, Taipas, Portugal

    J. M. Oliveira

  4. ICVS/3B’s – PT Government Associated Laboratory, Braga/Guimarães, Portugal

    J. M. Oliveira

  5. FIFA Medical Centre of Excellence, Clínica Espregueira-Mendes F.C. Porto Stadium, Porto, Portugal

    J. M. Oliveira

  6. Department of Biomedical Sciences, Humanitas University, Milan, Italy

    Elizaveta Kon

  7. Orthopaedic Arthroscopic Surgery International (O.A.S.I.) Bioresearch Foundation Gobbi NPO, Milan, Italy

    Alberto Gobbi

  8. Musculoskeletal and Joint Research Foundation, San Diego, California, USA

    John Lane

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Decante, G., Cengiz, I.F., Silva-Correia, J., Reis, R.L., Oliveira, J.M. (2023). 3D Printed Meniscal Scaffolds. In: Espregueira-Mendes, J., Karlsson, J., Musahl, V., Ayeni, O.R. (eds) Orthopaedic Sports Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-65430-6_52-1

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  • DOI: https://doi.org/10.1007/978-3-030-65430-6_52-1

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