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Neuroendocrine Regulation of Hydrosaline Metabolism

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Hydro Saline Metabolism

Part of the book series: Endocrinology ((ENDOCR))

Abstract

The present chapter will address some evolutionary, historical, and contemporary perspectives concerning the integrative neuroendocrine control of hydrosaline metabolism, focusing on the major neural and endocrine systems implicated in the control of water and sodium balance. This chapter will bring the readers the new advances on the understanding of how our body controls extracellular fluid volume and osmolality, initiating with the sensory afferent mechanisms and advancing on effector responses accomplished by an integrated action of the renin-angiotensin and autonomic systems, atrial natriuretic peptides, and hypothalamic neurohypophysial hormones. We will also discuss the contribution of transcriptomic analyses to the study of magnocellular neurosecretory function, and also how novel regulators (gaseous modulators, endocannabinoids, and glial cells) have increased the complexity of this already robust network. Finally, the chapter will illustrate how the neuroendocrine regulation of hydromineral balance behaves under normal or pathological life span challenges, such as adaptations in response to fetal programing, sex- and age-related management of water/sodium balances, and physical activity.

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Author information

Authors and Affiliations

  1. Department of Physiological Sciences, Biomedical Sciences Institute, Federal University of Alfenas, Alfenas, Brazil

    Silvia Graciela Ruginsk

  2. Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil

    Lucila Leico Kagohara Elias & José Antunes-Rodrigues

  3. Department of Biophysics, Paulista School of Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil

    André Souza Mecawi

  4. Laboratory of Molecular Neuroendocrinology, Department of Biophysics, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil

    André Souza Mecawi

Authors
  1. Silvia Graciela Ruginsk
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  2. Lucila Leico Kagohara Elias
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  3. José Antunes-Rodrigues
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  4. André Souza Mecawi
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Corresponding author

Correspondence to André Souza Mecawi .

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Editors and Affiliations

  1. Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome, Italy

    Massimiliano Caprio

  2. Cardiovascular Research Center, Paris Descartes University, Paris, France

    Fabio Luiz Fernandes-Rosa

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Ruginsk, S.G., Elias, L.L.K., Antunes-Rodrigues, J., Mecawi, A.S. (2022). Neuroendocrine Regulation of Hydrosaline Metabolism. In: Caprio, M., Fernandes-Rosa, F.L. (eds) Hydro Saline Metabolism. Endocrinology. Springer, Cham. https://doi.org/10.1007/978-3-030-44628-4_1-1

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  • DOI: https://doi.org/10.1007/978-3-030-44628-4_1-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-44628-4

  • Online ISBN: 978-3-030-44628-4

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