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Benign (Reactive) Lymphoid Hyperplasia and Lymphoma

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Atlas of Orbital Imaging

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1 Signs and Symptoms

Lymphoproliferative disorders of the lacrimal gland are characteristically of insidious onset. The typical patient will experience gradually progressive painless proptosis over less than one year, with other signs of orbital dysfunction such as ptosis (temporal more than nasal), restriction in eye movements and double vision. Examination may reveal an enlarged lacrimal gland palpable in the superior sulcus as a firm rubbery and non-tender mass. Involvement of the conjunctival, eyelids or other ocular adnexa may also be present. About three-quarters of the cases are unilateral.

2 Differential Diagnosis

The differential diagnosis includes reactive (benign) lymphoid hyperplasia; lymphoma, with the vast majority (over 95%) being B-cell lymphomas, and the most common type being extranodular marginal zone lymphoma (EMZL). Other common types include follicular lymphoma, diffuse large B-cell lymphoma, and Mantle cell lymphoma. Other causes for painless enlargement of the...

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References

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Authors and Affiliations

  1. The Goldschleger Eye Institute, Sheba Medical Center, affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel

    Oded Sagiv

  2. Department of Neuroradiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    J. Matthew Debnam

  3. Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Bita Esmaeli

Authors
  1. Oded Sagiv
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  2. J. Matthew Debnam
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  3. Bita Esmaeli
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Corresponding author

Correspondence to Bita Esmaeli .

Editor information

Editors and Affiliations

  1. Orbital Ophthalmic Plastic & Lacrimal Surgery Institute, Sheba Medical Center, Tel Hashomer, Tel Aviv, Israel

    Guy Ben Simon

  2. Department of Diagnostic Imaging, Sheba Medical Center, Tel Hashomer, Israel

    Gahl Greenberg

  3. Orbital Ophthalmic Plastic & Lacrimal Surgery Institute, Sheba Medical Center, Tel Hashomer, Israel

    Daphna Prat

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Sagiv, O., Debnam, J.M., Esmaeli, B. (2021). Benign (Reactive) Lymphoid Hyperplasia and Lymphoma. In: Ben Simon, G., Greenberg, G., Prat, D. (eds) Atlas of Orbital Imaging . Springer, Cham. https://doi.org/10.1007/978-3-030-41927-1_20-1

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  • DOI: https://doi.org/10.1007/978-3-030-41927-1_20-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-41927-1

  • Online ISBN: 978-3-030-41927-1

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