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Chimerism in Hematopoietic Stem Cell Transplantation

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Contemporary Bone Marrow Transplantation

Part of the book series: Organ and Tissue Transplantation ((OTT))

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Abstract

The process of allogeneic hematopoietic stem cell transplantation is a complex and systematic procedure which begins from donor selection and culminates in the successful engraftment of the donor stem cells in the host environment. The degree of donor cell component in the recovering hematopoiesis in the host is a critical factor which affects posttransplant immunomodulation, relapse of primary disease, posttransplant complications, and ultimately the success of the transplantation. Hence methods for accurately monitoring the chimerism of donor and host hematopoiesis post allogeneic transplant are of utmost importance. The chimerism monitoring techniques have evolved over last few decades to provide very accurate information of not only the overall donor component in posttransplant hematopoiesis but also the degree of donor chimerism in each hematopoietic cell lineage. This chapter is a review of biology of chimerism, methods for testing chimerism, and the clinical role of chimerism in guiding allogeneic stem cell transplantation management.

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Authors and Affiliations

  1. Department of Laboratory Haematology, Molecular Genetics and Cytogenetics, Tata Medical Center, Kolkata, India

    Deepak Kumar Mishra

  2. Department of Molecular Genetics, Tata Medical Center, Kolkata, India

    Kunjal Ramanbhai Patel

  3. Department of Laboratory Haematology, Molecular Genetand Cytogenetics, Tata Medical Center, Kolkata, India

    Mayur Parihar

  4. S.L.Raheja (Fortis) Hospital, Mumbai, India

    Ashay Karpe

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  1. Deepak Kumar Mishra
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  1. Clinical Hematology Oncology and Hematopoietic Cell Transplantation, Tata Medical Center, Kolkata, India

    Mammen Chandy

  2. Clinical Hematology Oncology and Hematopoietic Cell Transplantation, Tata Medical Center, Kolkata, India

    Vivek S. Radhakrishnan

  3. Department of Pediatric Hematology-Oncology, Tata Medical Center, Kolkata, India

    Reghu K. Sukumaran

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  1. Tata Medical Center, Kolkata, India

    Vivek Radhakrishnan

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Mishra, D.K., Patel, K.R., Parihar, M., Karpe, A. (2021). Chimerism in Hematopoietic Stem Cell Transplantation. In: Chandy, M., Radhakrishnan, V.S., Sukumaran, R.K. (eds) Contemporary Bone Marrow Transplantation. Organ and Tissue Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-030-36358-1_37

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  • DOI: https://doi.org/10.1007/978-3-030-36358-1_37

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-36357-4

  • Online ISBN: 978-3-030-36358-1

  • eBook Packages: MedicineReference Module Medicine

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