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HSCT in Benign Hematological Disorders

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Contemporary Bone Marrow Transplantation

Part of the book series: Organ and Tissue Transplantation ((OTT))

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Abstract

Hemoglobinopathies and primary immunodeficiencies are inherited disorders with significant impact on quality of life and survival. They are mostly monogenic disorders amenable to treatment with hematopoietic stem cell transplantation (HSCT). In the past 4 decades, substantial experience has been gained in allogeneic HSCT for sickle cell disease, β-thalassemia major, and primary immunodeficiencies with excellent cure rates when HLA-identical related donors are used. Alternative donor HSCT with unrelated umbilical cord blood and haploidentical donors is generally associated with higher risks of transplant-related complications but is being increasingly explored in recent years to extend a chance of cure to patients without HLA-matched related donors. This chapter reviews general principles, patient selection, and contemporary results of HSCT in these nonmalignant hematological disorders.

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  1. Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA

    Suhag Parikh & Shanmuganathan Chandrakasan

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  1. Suhag Parikh
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  2. Shanmuganathan Chandrakasan
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Correspondence to Suhag Parikh .

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  1. Clinical Hematology Oncology and Hematopoietic Cell Transplantation, Tata Medical Center, Kolkata, India

    Mammen Chandy

  2. Clinical Hematology Oncology and Hematopoietic Cell Transplantation, Tata Medical Center, Kolkata, India

    Vivek S. Radhakrishnan

  3. Department of Pediatric Hematology-Oncology, Tata Medical Center, Kolkata, India

    Reghu K. Sukumaran

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  1. Tata Medical Center, Kolkata, India

    Vivek Radhakrishnan

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Parikh, S., Chandrakasan, S. (2021). HSCT in Benign Hematological Disorders. In: Chandy, M., Radhakrishnan, V.S., Sukumaran, R.K. (eds) Contemporary Bone Marrow Transplantation. Organ and Tissue Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-030-36358-1_34

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