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Allogeneic Transplant Overview and Matched Related Donor Transplant

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Contemporary Bone Marrow Transplantation

Part of the book series: Organ and Tissue Transplantation ((OTT))

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Abstract

Allogeneic hematopoietic cell transplantation utilizes the potential of an alloreactive graft-versus-tumor effect for the treatment of hematologic malignancies and other malignant and nonmalignant diseases. Since the first allogeneic transplants more than five decades ago, significant advances have occurred in transplantation technology, donor availability, and supportive care that have made transplantation safer and increasingly available to patients, and survival after transplantation continues to improve. This chapter will review the clinical rationale for using allogeneic transplantation and provide an overview of its indications, process, and complications. In addition, the chapter will review concepts and outcomes of matched related donor transplantation.

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Authors and Affiliations

  1. Blood and Marrow Transplant Program, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA

    Navneet S. Majhail

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  1. Navneet S. Majhail
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Correspondence to Navneet S. Majhail .

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  1. Clinical Hematology Oncology and Hematopoietic Cell Transplantation, Tata Medical Center, Kolkata, India

    Mammen Chandy

  2. Clinical Hematology Oncology and Hematopoietic Cell Transplantation, Tata Medical Center, Kolkata, India

    Vivek S. Radhakrishnan

  3. Department of Pediatric Hematology-Oncology, Tata Medical Center, Kolkata, India

    Reghu K. Sukumaran

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  1. Tata Medical Center, Kolkata, India

    Vivek Radhakrishnan

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Majhail, N.S. (2021). Allogeneic Transplant Overview and Matched Related Donor Transplant. In: Chandy, M., Radhakrishnan, V.S., Sukumaran, R.K. (eds) Contemporary Bone Marrow Transplantation. Organ and Tissue Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-030-36358-1_18

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