Abstract
The Ras-related GTPase Rap has been implicated in multiple cellular functions. In particular, Rap1 is a crucial regulator of both inside-out integrin activation and outside-in E-cadherin-mediated signaling. Thus, Rap1 was proposed as a fundamental regulator of the cross talk between cadherins and integrins. We provide microscopic techniques to study subcellular localization of Rap1 protein in the crosstalk between integrins and cadherins.
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Goitre, L., Cutano, V., Retta, S.F. (2014). Fluorescence Microscopy Study of Rap1 Subcellular Localization. In: Trabalzini, L., Retta, S. (eds) Ras Signaling. Methods in Molecular Biology, vol 1120. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-791-4_13
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DOI: https://doi.org/10.1007/978-1-62703-791-4_13
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Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-62703-790-7
Online ISBN: 978-1-62703-791-4
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