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Transplantation Tolerance

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Transplantation Immunology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1034))

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Abstract

Tolerance has been defined as graft-specific survival in the absence of continued immunosuppression. The mechanisms of central and peripheral tolerance are discussed in this review, as well as the barriers and limitations in achieving graft-specific tolerance. The need remains for definitive laboratory assays to determine the presence of a tolerant state. Genetic biomarker analysis pre-transplant may allow for better donor: recipient matching, lessening the need for immunosuppression, while post-transplant analysis of biomarkers, certain cytokines, and regulatory leukocytes may permit minimally invasive assessment of graft function and potentially, of graft-specific tolerance.

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Authors and Affiliations

  1. Departments of Surgery and Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA

    Colin Brinkman, Bryna Burrell & Jonathan S. Bromberg

  2. Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA

    Joseph Scalea

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  1. Colin Brinkman
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  2. Bryna Burrell
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  3. Joseph Scalea
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  4. Jonathan S. Bromberg
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  1. , Immunogenetics Laboratory, Johns Hopkins University School of Medic, E. Monument Street 2041, Baltimore, 21205, Maryland, USA

    Andrea A. Zachary

  2. , Immunogenetics Laboratory, Johns Hopkins University School of Medic, E. Monument Street 2041, Baltimore, 21205, Maryland, USA

    Mary S. Leffell

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Brinkman, C., Burrell, B., Scalea, J., Bromberg, J.S. (2013). Transplantation Tolerance. In: Zachary, A., Leffell, M. (eds) Transplantation Immunology. Methods in Molecular Biology, vol 1034. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-493-7_4

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  • DOI: https://doi.org/10.1007/978-1-62703-493-7_4

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