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The Application of Transgenic Mice for Therapeutic Antibody Discovery

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Antibody Methods and Protocols

Part of the book series: Methods in Molecular Biology ((MIMB,volume 901))

Abstract

In 2006, panitumumab, the first fully human antibody generated from transgenic mice, was approved for clinical use by the US Food and Drug Administration (FDA). Since then, a further seven such antibodies have been approved. In this chapter, we discuss how transgenic mice technologies can provide a powerful platform for creating human therapeutic antibodies.

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Acknowledgments

We thank Allan Bradley, Andrew Sandham, and Glenn Friedrich for critical comments, and all other colleagues at Kymab for helpful discussion.

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Authors and Affiliations

  1. Kymab Ltd, Meditrina, Cambridge, UK

    E-Chiang Lee & Michael Owen

Authors
  1. E-Chiang Lee
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  2. Michael Owen
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Corresponding author

Correspondence to E-Chiang Lee .

Editor information

Editors and Affiliations

  1. The Jackson Laboratory, Main Street 600, Bar Harbor, 04609, Maine, USA

    Gabriele Proetzel

  2. Novartis Pharma AG, Postfach, Basel, 4002, Switzerland

    Hilmar Ebersbach

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Lee, EC., Owen, M. (2012). The Application of Transgenic Mice for Therapeutic Antibody Discovery. In: Proetzel, G., Ebersbach, H. (eds) Antibody Methods and Protocols. Methods in Molecular Biology, vol 901. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-931-0_8

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  • DOI: https://doi.org/10.1007/978-1-61779-931-0_8

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61779-930-3

  • Online ISBN: 978-1-61779-931-0

  • eBook Packages: Springer Protocols

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