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The Integration and Annotation of the Human Interactome in the UniHI Database

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Two Hybrid Technologies

Part of the book series: Methods in Molecular Biology ((MIMB,volume 812))

Abstract

In recent years, remarkable progress has been made toward the systematic charting of human protein interactions. The utilization of the generated interaction data remained however challenging for biomedical researchers due to lack of integration of currently available resources. To facilitate the direct access and analysis of the human interactome, we have developed the Unified Human Interactome (UniHI) database. It provides researchers with a user-friendly Web-interface and integrates interaction data from 12 major resources in its latest version, establishing one of the largest catalogs for human PPIs worldwide. At present, UniHI houses over 250,000 distinct interactions between 22,300 unique proteins and is publically available at http://www.unihi.org.

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Acknowledgments

The development and implementation of UniHI was funded by the SFB 618 grant of the Deutsche Forschungsgesellschaft (DFG). We would also like to acknowledge the support of M.F by the Portuguese Fundação para a Ciência e Tecnologia (IBB/CBME, LA.

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Authors and Affiliations

  1. Charité, Humboldt University, Berlin, Germany

    Gautam Chaurasia

  2. Centre for Molecular and Structural Biomedicine, University of Algarve, Faro, Portugal

    Matthias Futschik

Authors
  1. Gautam Chaurasia
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  2. Matthias Futschik
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Correspondence to Matthias Futschik .

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Editors and Affiliations

  1. Molekulare Medizin (MDC), Max-Delbrück-Centrum für, Robert-Rössle-Str. 10, Berlin-Buch, 13125, Germany

    Bernhard Suter

  2. Max-Delbrück-Centrum-Für Molekulare Medi, Robert-Rössle-Strabe 10, Berlin, 13125, Berlin, Germany

    Erich E. Wanker

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Chaurasia, G., Futschik, M. (2012). The Integration and Annotation of the Human Interactome in the UniHI Database. In: Suter, B., Wanker, E. (eds) Two Hybrid Technologies. Methods in Molecular Biology, vol 812. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-455-1_10

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  • DOI: https://doi.org/10.1007/978-1-61779-455-1_10

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61779-454-4

  • Online ISBN: 978-1-61779-455-1

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