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PET and PET–CT in Esophageal and Gastric Cancer

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Positron Emission Tomography

Part of the book series: Methods in Molecular Biology ((MIMB,volume 727))

Abstract

Esophageal cancer ranks among the ten most common malignancies in the world and is a frequent cause of cancer-related death. Almost all therapeutic modalities for esophageal cancer are associated with considerable mortality and morbidity. Consequently, there has been growing concern regarding effective management of esophageal cancer. Imaging plays an important role in the initial selection of patients. 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) is playing an increasing role in the management of esophageal cancer. The role of FDG-PET in diagnosis, preoperative staging, monitoring of response to neoadjuvant therapy, and detection of disease recurrence is evaluated in this chapter.

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References

  1. Flamen, P., Lerut, A., Van Cutsem, E., et al. (2000) Utility of positron emission tomography for the staging of patients with potentially operable esophageal carcinoma. J Clin Oncol 18, 3202–10.

    PubMed  CAS  Google Scholar 

  2. Heeren, P.A., Jager, P.L., Bongaerts, F., van Dullemen, H., Sluiter, W., Plukker, J.T. (2004) Detection of distant metastases in esophageal cancer with (18)F-FDG PET.J Nucl Med 45, 980–7.

    PubMed  Google Scholar 

  3. Kato, H., Kuwano, H., Nakajima, M., et al. (2002) Usefulness of positron emission tomography for assessing the response of neoadjuvant chemoradiotherapy in patients with esophageal cancer. Am J Surg 184, 279–83.

    Article  PubMed  Google Scholar 

  4. Kim, K., Park, S.J., Kim, B.T., Lee, K.S., Shim, Y.M. (2001) Evaluation of lymph node metastases in squamous cell carcinoma of the esophagus with positron emission tomography. Ann Thorac Surg 71, 290–4.

    Article  PubMed  CAS  Google Scholar 

  5. McAteer, D., Wallis, F., Couper, G., et al. (1999) Evaluation of F-18 FDG positron emission tomography in gastric and oesophageal carcinoma. Br J Radiol 72, 525–9.

    PubMed  CAS  Google Scholar 

  6. Meltzer, C.C., Luketich, J.D., Friedman, D., et al. (2000) Whole-body FDG positron emission tomographic imaging for staging esophageal cancer comparison with computed tomography. Clin Nucl Med 25, 882–7.

    Article  PubMed  CAS  Google Scholar 

  7. Yoon, Y.C., Lee, K.S., Shim, Y.M., Kim, B.T., Kim, K., Kim, T.S. (2003) Metastasis to regional lymph nodes in patients with esophageal squamous cell carcinoma: CT versusFDG PET for presurgical detection prospective study. Radiology 227, 764–70.

    Article  PubMed  Google Scholar 

  8. Rasanen, J.V., Sihvo, E.I., Knuuti, M.J., et al. (2003) Prospective analysis of accuracy of positron emission tomography, computed tomography, and endoscopic ultrasonography in staging of adenocarcinoma of the esophagus and the esophagogastric junction. Ann Surg Oncol 10, 954–60.

    Article  PubMed  Google Scholar 

  9. Herrmann, K., Ott, K., Buck, A.K., et al. (2007) Imaging gastric cancer with PET and the radiotracers 18F-FLT and F-18 FDG: A comparative analysis. J Nucl Med 48, 1945–50.

    Article  PubMed  CAS  Google Scholar 

  10. van Westreenen, H.L., Westerterp, M., Bossuyt, P.M., et al. (2004) Systematic review of the staging performance of 18F-fluorodeoxyglucose positron emission tomography in esophageal cancer. J Clin Oncol 22, 3805–12.

    Article  PubMed  Google Scholar 

  11. Choi, J.Y., Lee, K.H., Shim, Y.M., et al. (2000) Improved detection of individual nodal involvement in squamous cell carcinoma of the esophagus by FDG PET. J Nucl Med 41, 808–15.

    PubMed  CAS  Google Scholar 

  12. Lerut, T., Flamen, P., Ectors, N., et al. (2000) Histopathologic validation of lymph node staging with FDG-PET scan in cancer of the esophagus and gastroesophageal junction: A prospective study based on primary surgery with extensive lymphadenectomy. Ann Surg 232, 743–52.

    Article  PubMed  CAS  Google Scholar 

  13. Yuan, S., Yu, Y., Chao, K.S., et al. (2006) Additional value of PET-CT over PET in assessment of locoregional lymph nodes in thoracic esophageal squamous cell cancer.J Nucl Med 47, 1255–9.

    PubMed  Google Scholar 

  14. Kim, S.K., Kang, K.W., Lee, J.S., et al. (2006) Assessment of lymph node metastases using F-18 FDG PET in patients with advanced gastric cancer. Eur J Nucl Med Mol Imaging 33, 148–55.

    Article  PubMed  Google Scholar 

  15. Kato, H., Miyazaki, T., Nakajima, M., Fukuchi, M., Manda, R., Kuwano, H. (2004) Value of positron emission tomography in the diagnosis of recurrent oesophageal carcinoma. Br J Surg 91, 1004–9.

    Article  PubMed  CAS  Google Scholar 

  16. Flamen, P., Lerut, A., Van Cutsem, E., et al. (2000) The utility of positron emission tomography for the diagnosis and staging of recurrent esophageal cancer. J Thorac Cardiovasc Surg 120, 1085–92.

    Article  PubMed  CAS  Google Scholar 

  17. De Potter, T., Flamen, P., Van Cutsem, E., et al. (2002) Whole-body PET with FDG for the diagnosis of recurrent gastric cancer. Eur J Nucl Med Mol Imaging 29, 525–9.

    Article  PubMed  Google Scholar 

  18. Park, M.J., Lee, W.J., Lim, H.K., Park, K.W., Choi, J.Y., Kim, B.T. (2009) Detecting recurrence of gastric cancer: The value of FDG PET-CT. Abdom Imaging 34, 441–7.

    Article  PubMed  Google Scholar 

  19. Mandard, A.M., Dalibard, F., Mandard, J.C., et al. (1994) Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma clinicopathologic correlations. Cancer 73, 2680–6.

    Article  PubMed  CAS  Google Scholar 

  20. Weber, W.A., Ott, K., Becker, K., et al. (2001) Prediction of response to preoperative chemotherapy in adenocarcinomas of the esophagogastric junction by metabolic imaging.J Clin Oncol 19, 3058–65.

    PubMed  CAS  Google Scholar 

  21. Wieder, H.A., Brucher, B.L., Zimmermann, F., et al. (2004) Time course of tumor metabolic activity during chemoradiotherapy of esophageal squamous cell carcinoma and response to treatment. J Clin Oncol 22, 900–8.

    Article  PubMed  CAS  Google Scholar 

  22. Therasse, P., Arbuck, S.G., Eisenhauer, E.A., et al. (2000) New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst 92, 205–16.

    Article  PubMed  CAS  Google Scholar 

  23. Buyse, M., Piedbois, Y., Piedbois, P., Gray, R. (2000) Tumour site, sex, and survival in colorectal cancer. Lancet 356, 858.

    Article  PubMed  CAS  Google Scholar 

  24. Bruzzi, P., Del Mastro, L., Sormani, M.P., et al. (2005) Objective response to chemotherapy as a potential surrogate end point of survival in metastatic breast cancer patients.J Clin Oncol 23, 5117–25.

    Article  PubMed  Google Scholar 

  25. Goffin, J., Baral, S., Tu, D., Nomikos, D., Seymour, L. (2005) Objective responses in patients with malignant melanoma or renal cell cancer in early clinical studies do not predict regulatory approval. Clin Cancer Res 11, 5928–34.

    Article  PubMed  Google Scholar 

  26. Ratain, M.J. (2005) Phase II oncology trials: Let’s be positive. Clin Cancer Res 11, 5661–2.

    Article  PubMed  Google Scholar 

  27. Weber, W.A., Ziegler, S.I., Thodtmann, R., Hanauske, A.R., Schwaiger, M. (1999)Reproducibility of metabolic measurements in malignant tumors using FDG PET. J Nucl Med 40, 1771–7.

    PubMed  CAS  Google Scholar 

  28. Westerterp, M., van Westreenen, H.L., Reitsma, J.B., et al. (2005) Esophageal cancer: CT, endoscopic US, and FDG PET for assessment of response to neoadjuvant therapy – systematic review. Radiology 236, 841–51.

    Article  PubMed  Google Scholar 

  29. Brucher, B.L., Weber, W., Bauer, M., et al. (2001) Neoadjuvant therapy of esophageal squamous cell carcinoma: Response evaluation by positron emission tomography. Ann Surg 233, 300–9.

    Article  PubMed  CAS  Google Scholar 

  30. Flamen, P., Van Cutsem, E., Lerut, A., et al. (2002) Positron emission tomography for assessment of the response to induction radiochemotherapy in locally advanced esophageal cancer. Ann Oncol 13, 361–8.

    Article  PubMed  CAS  Google Scholar 

  31. Port, J.L., Lee, P.C., Korst, R.J., et al. (2007) Positron emission tomographic scanning predicts survival after induction chemotherapy for esophageal carcinoma. Ann Thorac Surg 84, 393–400; discussion.

    Article  PubMed  Google Scholar 

  32. Swisher, S.G., Maish, M., Erasmus, J.J., et al. (2004) Utility of PET, CT, and EUS to identify pathologic responders in esophageal cancer. Ann Thorac Surg 78, 1152–60; discussion 60.

    Article  PubMed  Google Scholar 

  33. Smithers, B.M., Couper, G.C., Thomas, J.M., et al. (2008) Positron emission tomography and pathological evidence of response to neoadjuvant therapy in adenocarcinoma of the esophagus. Dis Esophagus 21, 151–8.

    Article  PubMed  CAS  Google Scholar 

  34. Lordick, F., Ruers, T., Aust, D.E., et al. (2008) European Organisation of Research and Treatment of Cancer (EORTC) Gastrointestinal Group: Workshop on the role of metabolic imaging in the neoadjuvant treatment of gastrointestinal cancer. Eur J Cancer 44, 1807–19.

    Article  PubMed  Google Scholar 

  35. Westerterp, M., Sloof, G.W., Hoekstra, O.S., et al. (2008) 18FDG uptake in oesophageal adenocarcinoma: Linking biology and outcome. J Cancer Res Clin Oncol 134, 227–36.

    Article  PubMed  Google Scholar 

  36. Siewert, J.R., Stein, H.J., Sendler, A., Fink, U. (1999) Surgical resection for cancer of the cardia. Semin Surg Oncol 17, 125–31.

    Article  PubMed  CAS  Google Scholar 

  37. Ott, K., Weber, W.A., Lordick, F., et al. (2006) Metabolic imaging predicts response, survival, and recurrence in adenocarcinomas of the esophagogastric junction. J Clin Oncol 24, 4692–8.

    Article  PubMed  Google Scholar 

  38. Lordick, F., Ott, K., Krause, B.J., et al. (2007) PET to assess early metabolic response and to guide treatment of adenocarcinoma of the oesophagogastric junction: The MUNICON phase II trial. Lancet Oncol 8, 797–805.

    Article  PubMed  Google Scholar 

  39. Ott, K., Herrmann, K., Lordick, F., et al. (2008) Early metabolic response evaluation by fluorine-18 fluorodeoxyglucose positron emission tomography allows in vivo testing of chemosensitivity in gastric cancer: Long-term results of a prospective study. Clin Cancer Res 14, 2012–8.

    Article  PubMed  CAS  Google Scholar 

  40. Shah, M.A., Yeung, H.W., Coit, D., Trocola, R., Ilson, D., Randazzo, J. (2007) A phase II study of preoperative chemotherapy with irinotecan (CPT) and cisplatin (CIS) for gastric cancer (NCI 5917): FDG-PET-CT predicts patient outcome. J Clin Oncol 25, 18S.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Radiology, Klinikum rechts der Isar, Technische Universität München, München, Germany

    Hinrich A. Wieder

  2. Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, München, Germany

    Bernd J. Krause & Ken Herrmann

Authors
  1. Hinrich A. Wieder
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  2. Bernd J. Krause
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  3. Ken Herrmann
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Corresponding author

Correspondence to Hinrich A. Wieder .

Editor information

Editors and Affiliations

  1. Dept. Radiology, University of Iowa, Hawkins Drive 200, Iowa City, 52242-1009, Iowa, USA

    Malik E. Juweid

  2. , Dept. Nuclear Medicine & PET Research, VU University Medical Centre, De Boelelaan 1117, Amsterdam, 1081 HV, Netherlands

    Otto S. Hoekstra

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© 2011 Humana Press

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Wieder, H.A., Krause, B.J., Herrmann, K. (2011). PET and PET–CT in Esophageal and Gastric Cancer. In: Juweid, M., Hoekstra, O. (eds) Positron Emission Tomography. Methods in Molecular Biology, vol 727. Humana Press. https://doi.org/10.1007/978-1-61779-062-1_5

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  • DOI: https://doi.org/10.1007/978-1-61779-062-1_5

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61779-061-4

  • Online ISBN: 978-1-61779-062-1

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