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The Family of G Protein-Coupled Receptors: An Example of Membrane Proteins

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Membrane Protein Structure Determination

Part of the book series: Methods in Molecular Biology ((MIMB,volume 654))

Abstract

The G protein coupled receptors belong to the largest group of membrane proteins that regulates many essential physiological properties and represents an important class of drug targets. In this chapter, we show how the synergy between a laboratory experiment and computational modeling leads to structural delineation of the ligand binding pocket and how the knowledge of ligand–protein interactions is used for rational local and global drug design in which the structural knowledge of a particular receptor and its ligands is used for drug design of this particular GPCR and others.

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Authors and Affiliations

  1. INSERM, Institut National de la Santé et de la Recherche Médicale, Université de Toulouse 3, Toulouse, France

    Irina G. Tikhonova & Daniel Fourmy

Authors
  1. Irina G. Tikhonova
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  2. Daniel Fourmy
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Corresponding author

Correspondence to Irina G. Tikhonova .

Editor information

Editors and Affiliations

  1. , Université Paris Diderot - Paris 7, INSERM U773/CRB3, rue Henri Huchard 16, Paris, 75018, France

    Jean-Jacques Lacapère

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Tikhonova, I.G., Fourmy, D. (2010). The Family of G Protein-Coupled Receptors: An Example of Membrane Proteins. In: Lacapère, JJ. (eds) Membrane Protein Structure Determination. Methods in Molecular Biology, vol 654. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-762-4_23

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  • DOI: https://doi.org/10.1007/978-1-60761-762-4_23

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-761-7

  • Online ISBN: 978-1-60761-762-4

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