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Membrane Protein Dynamics from Femtoseconds to Seconds

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Membrane Protein Structure Determination

Part of the book series: Methods in Molecular Biology ((MIMB,volume 654))

Abstract

Membrane proteins play a key role in energy conversion, transport, signal recognition, transduction, and other fundamental biological processes. Despite considerable progress in experimental techniques, the determination of structure and dynamics of membrane proteins still represents a great challenge. Computer simulation methods are becoming an increasingly important tool not only in the interpretation of experiments but also in the prediction of membrane protein dynamics. In the present review, we give a brief introduction to molecular modeling techniques currently used to explore protein dynamics on time scales ranging from femtoseconds to microseconds. We then describe a few recent example applications of these techniques to membrane proteins. In conclusion, we also discuss some of the newest developments in simulation methodology that have the potential to further extend the time scale accessible to explore (membrane) protein dynamics.

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Acknowledgments

We thank Frank Wennmohs and Emppu Salonen for their fruitful discussions. This work is supported by the Academy of Finland and its Center of Excellence, and by the Ministerium für Innovation, Wissenschaft, Forschung und Technologie des Landes Nordrhein-Westfalen. CK is a junior research group leader funded by the NRW Rückkehrerprogramm.

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  1. Computational Structural Biology, Chair of Life Science Informatics B-IT, Life & Medical Sciences (LIMES) Center, Rheinische Friedrich-Wilhelms-University Bonn, Bonn, Germany

    Christian Kandt

  2. UMR-S665, DSIMB, INSERM, 6, rue Alexandre Cabanel, 75015, Paris, France

    Luca Monticelli

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  1. Christian Kandt
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  2. Luca Monticelli
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Correspondence to Luca Monticelli .

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  1. , Université Paris Diderot - Paris 7, INSERM U773/CRB3, rue Henri Huchard 16, Paris, 75018, France

    Jean-Jacques Lacapère

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Kandt, C., Monticelli, L. (2010). Membrane Protein Dynamics from Femtoseconds to Seconds. In: Lacapère, JJ. (eds) Membrane Protein Structure Determination. Methods in Molecular Biology, vol 654. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-762-4_22

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  • DOI: https://doi.org/10.1007/978-1-60761-762-4_22

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