Abstract
This chapter describes the application of gold nanorods in biomedical imaging and photothermal therapy. The photothermal properties of gold nanorods are summarized and the synthesis as well as antibody conjugation of gold nanorods is outlined. Biomedical applications of gold nanorods include cancer imaging using their enhanced scattering property and photothermal therapy using their enhanced nonradiative photothermal property.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Mie, G. (1908) Contribution to the optics of turbid media, especially colloidal metal suspensions. Ann Phys 25, 377–445.
Gans, R. (1915) Form of ultramicroscopic particles of silver. Ann Phys 47, 270–284.
Papavassiliou, G. C. (1979) Optical properties of small inorganic and organic metal particles. Prog Solid State Chem 12, 185–271.
Link, S., Mohamed, M. B., and El-Sayed, M. A. (1999) Simulation of the optical absorption spectra of gold nanorods as a function of their aspect ratio and the effect of the medium dielectric constant. J Phys Chem B 103, 8410–8426.
Link, S. and El-Sayed, M. A. (2005) Additions and corrections to simulation of the optical absorption spectra of gold nanorods as a function of their aspect ratio and the effect of the medium dielectric constant. J Phys Chem B 109, 10531–10532.
Sönnichsen, C., Franzl, T., Wilk, T., Plessen, G. V., and Feldmann, J. (2002) Drastic reduction of plasmon damping in gold nanorods. Phys Rev Lett 88, 077402–077406.
Zhu, J., Huang, L., Zhao, J., Wang, Y., Zhao, Y., Hao, L., and Lu, Y. (2005) Shape dependent resonance light scattering properties of gold nanorods. Mater Sci Eng B 121, 199–203.
Link, S. and El-Sayed, M. A. (2000) Shape and size dependence of radiative, non-radiative and photothermal properties of gold nanocrystals. Int Rev Phys Chem 19, 409–453.
Jain, P. K., Lee, K. S., El-Sayed, I. H., and El-Sayed, M. A. (2006) Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine. J Phys Chem B 110, 7238–7248.
Du, H., Fuh, R. A., Li, J., Corkan, A., and Lindsey, J. S. (1998) PhotochemCAD††: a computer-aided design and research tool in photochemistry. Photochem Photobiol 68, 141–142.
Weissleder, R. (2001) A clearer vision for in vivo imaging. Nat Biotechnol 19, 316–317.
Lee, K. S. and El-Sayed, M. A. (2005) Dependence of the enhanced optical scattering efficiency relative to that of absorption for gold metal nanorods on aspect ratio, size, end-cap shape, and medium refractive index. J Phys Chem B 109, 20331–20338.
Nikoobakht, B. and El-Sayed, M. A. (2003) Preparation and growth mechanism of gold nanorods using seed-mediated growth method. Chem Mater 15, 1957–1961.
Murphy, C. J., Sau, T. K., Gole, A. M., Orendorff, C. J., Gao, J., Gou, L., Hunyadi, S. E., and Li, T. (2005) Anisotropic metal nanoparticles: synthesis, assembly, and optical applications. J Phys Chem B 109, 13857–13870.
P’erez-Juste, J., Pastoriza-Santos, I., Liz-Marz’an, L. M., and Mulvaney, P. (2005) Gold nanorods: synthesis, characterization and applications. Coord Chem Rev 249, 1870–1901.
Orendorff, C. J. and Murphy, C. J. (2006) Quantitation of metal content in the silver-assisted growth of gold nanorods. J Phys Chem B 110, 3990–3994.
Huang, X., El-Sayed, I. H., and El-Sayed, M. A. (2006) Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. J Am Chem Soc 128, 2115–2120.
El-Sayed, I. H., Huang, X., and El-Sayed, M. A. (2006) Selective laser photo-thermal therapy of epithelial carcinoma using anti-EGFR antibody conjugated gold nanoparticles. Cancer Lett 239, 129–135.
Dickerson, E. B., Dreaden, E. C., Huang, X., El-Sayed, I. H., Chu, H., Pushpanketh, S., McDonald, J. F., and El-Sayed, M. A. (2008) Gold nanorods assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice. Cancer Lett 269, 57–66.
Harris, J. M. and Chess, R. B. (2003) Effect of pegylation on pharmaceuticals. Nat Rev Drug Discov 2, 214–221.
Huff, T. B., Hansen, M. N., Zhao, Y., Cheng, J. X., and Wei, A. (2007) Controlling the cellular uptake of gold nanorods. Langmuir 23, 1596–1599.
Liao, H. W. and Hafner, J. H. (2005) Gold nanorod bioconjugates. Chem Mater 17, 4636–4641.
Niidome, T., Yamagata, M., Okamoto, Y., Akiyama, Y., Takahashi, H., Kawano, T., Katayama, Y., and Niidome, Y. (2006) PEG-modified gold nanorods with a stealth character for in vivo applications. J Control Release 114, 343–347.
Maeda, H. (2001) The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. Adv Enzyme Regul 41, 189–207.
Jain, R. K. (1987) Transport of molecules in the tumor interstitium: a review. Cancer Res 47, 3039–3051.
Hirsch, L. R., Stafford, R. J., Bankson, J. A., Sershen, S. R., Rivera, B., Price, R. E., Hazle, J. D., Halas, N. J., and West, J. (2003) Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance. Proc Natl Acad Sci USA 100, 13549–13554.
Acknowledgment
We like to thank the support of the Chemical Science, Geosciences, and Bioscience Division of the Department of Energy (Grant DE-FG02-97ER14799) and the National Cancer Institute Center of Cancer Nanotechnology Excellence Award (U54CA119338).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer Science+Business Media, LLC
About this protocol
Cite this protocol
Huang, X., El-Sayed, I.H., El-Sayed, M.A. (2010). Applications of Gold Nanorods for Cancer Imaging and Photothermal Therapy. In: Grobmyer, S., Moudgil, B. (eds) Cancer Nanotechnology. Methods in Molecular Biology, vol 624. Humana Press. https://doi.org/10.1007/978-1-60761-609-2_23
Download citation
DOI: https://doi.org/10.1007/978-1-60761-609-2_23
Published:
Publisher Name: Humana Press
Print ISBN: 978-1-60761-608-5
Online ISBN: 978-1-60761-609-2
eBook Packages: Springer Protocols