Summary
Optical label-free detection prevents the cost and complexity of fluorescence and radio labeling while providing accurate quantitative and kinetic results. We have developed a new optical label-free sensor called the liquid core optical ring resonator (LCORR). The LCORR integrates optical ring resonator sensors into the microfluidic delivery system by using glass capillaries with a thin wall. The LCORR is capable of performing refractive index detection on liquid samples, as well as bio/chemical analyte detection down to detection limits on the scale of pg/mm2 on a sensing surface.
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White, I.M., Zhu, H., Suter, J.D., Fan, X., Zourob, M. (2009). Label-Free Detection with the Liquid Core Optical Ring Resonator Sensing Platform. In: Rasooly, A., Herold, K.E. (eds) Biosensors and Biodetection. Methods in Molecular Biology™, vol 503. Humana Press. https://doi.org/10.1007/978-1-60327-567-5_7
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DOI: https://doi.org/10.1007/978-1-60327-567-5_7
Publisher Name: Humana Press
Print ISBN: 978-1-60327-566-8
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