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Application of lacZ Transgenic Mice to Cell Lineage Studies

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Molecular Embryology

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References

  1. Kothary R, Clapoff S, Darling S, Perry MD, Moran LA, Rossant J (1988) Induc-ible expression of an hsp68-lacZ hybrid gene in transgenic mice. Development 105:707–714.

    Google Scholar 

  2. Tan SS, Williams EA, Tam PPL (1993) X-chromosome inactivation occurs at dif¬ferent times in different tissues of the post implantation mouse embryo. Nature Genet. 3:170–175.

    Article  CAS  PubMed  Google Scholar 

  3. Freidrich G, Soriano P (1991) Promotor traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev 5:1513– 1523;. Development 115:703–715.

    Google Scholar 

  4. Beddington RSP, Morgenstern J, Land H, Hogan A (1989) An in situ enzyme marker for the mid-gestation mouse embryo and the visualisation of inner cell mass clones during early organogenesis. Development 106:37–46.

    CAS  PubMed  Google Scholar 

  5. Lebon JM, Tam PP, Singer-Sam J, Riggs AD, Tan SS (1995) Mouse endogenous X-linked genes do not show lineage-specific delayed inactivation during develop¬ment. Genet Res 65(3):223–227.

    Article  CAS  PubMed  Google Scholar 

  6. Sugimoto M, Tan S-S, Takagi, N. (2000) X chromosome inactivation revealed by the X-linked lacZ transgene activity in periimplantation mouse embryos. Int J Dev Biol 44:177–182.

    CAS  PubMed  Google Scholar 

  7. Tan SS, Breen S (1993) Radial mosaicism and tangential cell dispersion both con¬tribute to mouse neocortical development. Nature 362:638–640.

    Article  CAS  PubMed  Google Scholar 

  8. Stone LM, Finger TE, Tam PPL, Tan SS (1995) Taste receptor cells arise from local epithelium, not neurogenic ectoderm. Proc Natl Acad Sci USA 92:1916–1920.

    Article  CAS  PubMed  Google Scholar 

  9. Tan SS,. Faulkner-Jones B, Breen SJ, Walsh M, Bertram JF, Reese BE (1995) Cell dispersion patterns in different cortical regions studied with an X-inactivated trans-genic marker. Development 121:1029–1039.

    CAS  PubMed  Google Scholar 

  10. Stone LM, Tan S-S, Tam PP, Finger TE (2002) Analysis of cell lineage relation¬ships in taste buds. J Neurosci 22(11):4522–4529.

    CAS  PubMed  Google Scholar 

  11. Echelard Y, Vassileva G, McMahon AP (1994) Cis-acting regulatory sequences gov¬erning Wnt-1 expression in the developing mouse CNS. Development 120:2213– 2224.

    CAS  PubMed  Google Scholar 

  12. Tan SS (1991) Liver specific and position effect expression of a retinol-binding protein-lacZ fusion gene (RBP-lacZ) in transgenic mice. Dev Biol 146:24–37.

    Article  CAS  PubMed  Google Scholar 

  13. Trainor PA, Tan SS, Tam PPL (1994). Cranial paraxial mesoderm: regionalisation of cell fate and impact upon craniofacial development in mouse embryos. Develop¬ment 120:2397–2408.

    CAS  PubMed  Google Scholar 

  14. Quinlan GA, Williams EA, Tan SS, Tam PPL (1995) Neuroectodermal fate of epi-blast cells in the distal region of the mouse egg cylinder: implication for body plan organisation during early embryogenesis. Development 121:87–948.

    CAS  PubMed  Google Scholar 

  15. Trainor PA, Tam PPL (1995) Cranial paraxial mesoderm and neural crest cells of the mouse embryo: co-distribution in the craniofacial mesenchyme but distinct segregation in branchial arches. Development 121:2569–2582.

    CAS  PubMed  Google Scholar 

  16. Reese BE, Harvey AR, Tan SS (1995) Radial and tangential dispersion patterns in the mouse retina are class specific. Proc Natl Acad Sci USA 92:2494–2498.

    Article  CAS  PubMed  Google Scholar 

  17. Bonnerot C, Rocancourt D, Briand P, Grimber G, Nicolas JF (1987) A β-galactosidase hybrid protein targeted to nuclei as a marker for developmental studies. Proc Natl Acad Sci USA 84:6795–6799.

    Article  CAS  PubMed  Google Scholar 

  18. Kalderon D, Roberts BL, Richardson WD, Smith AE (1984) A short amino acid sequence able to specify nuclear localisation. Cell 39:499–509.

    Article  CAS  PubMed  Google Scholar 

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Watson, C.M. et al. (2008). Application of lacZ Transgenic Mice to Cell Lineage Studies. In: Sharpe, P.T., Mason, I. (eds) Molecular Embryology. METHODS IN MOLECULAR BIOLOGY™, vol 461. Humana Press. https://doi.org/10.1007/978-1-60327-483-8_10

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  • DOI: https://doi.org/10.1007/978-1-60327-483-8_10

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-431-9

  • Online ISBN: 978-1-60327-483-8

  • eBook Packages: Springer Protocols

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