Skip to main content
SpringerLink
Log in

Multigenerational Information: The Example of the Icelandic Genealogy Database

  • Protocol
  • First Online:
Methods in Biobanking

Part of the book series: Methods in Molecular Biology ((MIMB,volume 675))

Abstract

The first part of the chapter describes the Icelandic Genealogical Database, how it was created, what it contains, and how it operates. In the second part, an overview of research accomplished with material from the database is given.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Protocol
USD 49.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Jensson, O., Palsdottir, A., Thorsteinsson, L. and Arnason, A. (1989) The saga of cystatin C gene mutation causing amyloid angiopathy and brain hemorrhage – clinical genetics in Iceland. Clin. Genet. 47, 368–377.

    Google Scholar 

  2. Jensson, O., Jonasson, T. and Olafsson, O. (1967) Hereditary elliptocytosis in Iceland. Br. J. Haematol. 13, 844–854.

    Article  PubMed  CAS  Google Scholar 

  3. Jensson, O., Jonasson, J. L. and Magnusson, S. (1977) Studies on herediatary spherocytosis in Iceland. Acta Med. Scand. 201, 187–195.

    Article  PubMed  CAS  Google Scholar 

  4. Jensson, O., Arnason, K., Johannesson G. M. and Ulfarsson J. (1977) Studies on the Pelger anomaly in Iceland. Acta Med. Scand. 201, 183–185.

    Article  PubMed  CAS  Google Scholar 

  5. Jensson, O. and Wallett, L. H. (1970) Von Willebrand’s disease in an Icelandic family. Acta Med. Scand. 187, 229–234.

    Article  PubMed  CAS  Google Scholar 

  6. Magnusson, L. (1981) Atrophia areata: a variant of peripapillary chorioretinal degerneration. Acta Ophthalmol. (Copenh) 59, 659–664.

    CAS  Google Scholar 

  7. Sykes, B., Ogilvie, D., Wordsworth, P., Wallis, G., Mathes, C., Beighton, P., Nichols, A., Pope, M., Thomson, E., Tsipouras, P., Schwartz, R., Jensson, O., Arnason, A., Borresen, A. L., Heiberg, A., Frey, D. and Steinmann, B. (1990) Consistent linkage of dominantly inherited osteogenesis imperfecta to the two collagen 1 loci: COLIA1 and 47 COLIA2. Am. J. Hum. Genet. 47, 592–594.

    Google Scholar 

  8. Gudmundsson, G., Jensson, O., Arnason, A. and Stefansson, K. (1989) Huntington’s chorea in Iceland: epidemiological study. Clin. Genet. 35, 225.

    Google Scholar 

  9. Bjarnason, I., Jonsson, S. and Hardarson, Th. (1982). Mode of inheritance of Hypertrophic cardiomyopathy in Iceland. Echographic study. Br. Heart J. 47, 122–129.

    Article  PubMed  CAS  Google Scholar 

  10. Karlsson, J. L. (1988). Partly dominant transmission of Schizophrenia in Iceland. Br. J. Psychiatry. 152, 324–329.

    Article  PubMed  CAS  Google Scholar 

  11. Sherrington, T., Brynjolfsson, J., Petursson, H., Potter, M., Duleston, K., Barraclough, B., Wasmuth, J., Dobbs, M. and Gurling, H. (1988). Localization of a susceptibility locus for schizophrenia on chromosome 5. Nature 336, 164–167.

    Article  PubMed  CAS  Google Scholar 

  12. Arnason, A., Steinsson, K., Fossdal, R., Gunnarsdottir, H., Thorsteinsson, L., Palsdottir, A., Valdimarsson, H., Erlendsson, K. and Jensson, O. (1989). Deficiency of the second component (C2) in Iceland – a study of two cases. Clin. Genet. 35, 215.

    Google Scholar 

  13. Gütller, F., Ludvigsson, P., Gregersen, N. and Gerdes, A. M. (1989). The first published cases of isovaleric acidaemia in Scandinavia are from Iceland. Clin. Genet. 35, 218.

    Google Scholar 

  14. Laxdal, Th. and Jonasson, T. A. (1989). 2.8-Dihydroxyadenine crystalluria in Iceland. Clin. Genet. 35, 219.

    Google Scholar 

  15. Gütller, F., Laxdal, Th. and Sweetman, L. (1989). A new variant of biotin responsive holocarboxylase synthetase deficiency found in Iceland. Clin. Genet. 35, 220.

    Google Scholar 

  16. Jensson, O. and Arnason, A. (1989). Recessive osteopetrosis in Iceland. Clin Genet. 35, 223.

    Google Scholar 

  17. Jensson, O., Baldursson, B. T. and Arnason, A. (1989) Autosomal recessive ichtyosis, lamellar type, in Iceland. Clin. Genet. 35, 224.

    Google Scholar 

  18. Jonsson, J. J., Jonasson, J. G., Sigurdsson, Th., Stefansdottir, A. and Halldorsson, S. (1989). Homocystinuria (cystathionine betasynthase deficiency) in Iceland. Clin. Genet. 35, 224.

    Google Scholar 

  19. Arnason, A., Jensson, O. and Gudmundsson, S. (1975) Serum esterases of Icelanders I. A “silent” pseudocholinesterase gene in an Icelalndic family. Clin. Genet. 7, 405–412.

    Article  PubMed  CAS  Google Scholar 

  20. Arnason, A., Fossdal, R., Thorsteinsson, A. and Jensson, O. (1989) Serum cholinesterase at the E1 locus in Icelanders. Clin. Genet. 35, 226.

    Google Scholar 

  21. Arnason, A., Gudmundsson, Th., Fossdal, R. and Jensson, O. (1989) Chromosome 6 markers and congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency in Iceland Clin. Genet. 5, 227.

    Google Scholar 

  22. Moore, G. E., Ivens, A., Chambers, J., Farrall, M., Williamson, R., Page, D. C., Björnsson, A., Arnason, A. and Jensson, O. (1987) Linkage of an X-chromosome cleft palate gene. Nature 326, 91–92.

    Article  PubMed  CAS  Google Scholar 

  23. Ivens, A., Moore, G. E, Chambers J., Arnason A., Jensson, O., Björnsson, A. and Williamson, R. (1987) X-linked cleft palate: the gene is localized between polymorphic DNA markers DXYS12 and DXS17. Hum. Genet. 78, 356–358.

    Article  Google Scholar 

  24. Moore, G., Ivens, A., Chambers, J., Björnsson, A., Arnason, A., Jensson, O. and Williamson, R. (1988) The application of molecular genetics to detection of craniofacial abnormality. Development. 103, 233–239.

    PubMed  Google Scholar 

  25. Jensson, O., Arnason, A., Gunnarsdottir, I., Petursdottir, I., Fossdal, R. and Hreidarsson, S. (1988) A family showing apparent X linked inheritance of both anencephaly and spina bifida. J. Med. Genet. 25, 227–229.

    Article  PubMed  CAS  Google Scholar 

  26. Hardardottir, H., Geirsson, R. T. and Hreidarsson, S. (1989) Placental sulfatase deficiency. Clin. Genet. 35, 224.

    Google Scholar 

  27. Thordarson, K. and Gislason, I. (1989). Herreditary juvenile retionschisis in an Icelandic family. Clin. Genet. 35, 225.

    Google Scholar 

  28. Jensson, O. (1979) Haemophilia A. Nordic Council Arct. Res. Rep. 26, 29–33.

    Google Scholar 

  29. Sigurdsson, G. A., Arnason, A., Gudmundsson Th. V., Kjeld, M., Franzson, L. and Sigurdsson, G. (1984) Familial elevation of serum thyroxine binding globulin in an Icelandic Family. Acta Endocirnol. 107, 352–356.

    CAS  Google Scholar 

  30. Thorsteinsson, L., Ögmundsdottir, H., Sigfusson, A., Arnason, A., Eyjolfsson, G. and Jensson, O. (1989) An Icelandic family with hypogammaglobulinemia, genetical and immunological study. Clin. Genet. 35, 226.

    Google Scholar 

  31. Juginder, K., Catovsky, D., Valdimarsson, H., Jensson, O. and Spiers, A. S. D. (1972) Familial acute myeloid leukaemia with acquired Pelger-Huët anomaly and aneuploidy of C group.Br. Med. J. 4, 327–331.

    Article  Google Scholar 

  32. Björnsson, O. G., Arnason, A., Gudmundsson, S., Jensson, O, Olafsson, S. and Valdimarsson, H. (1978) Macroglobulinaemia in an Icelandic Family. Acta Med. Scand. 203, 283–288.

    Article  PubMed  Google Scholar 

  33. Jensson, O., Björnsson, O. G., Arnason, A., Birgisdottir, B. and Pepys, M. B. (1982) Serum amyloid p-component and C-reactive protein in serumof healthy Icelanders and members of an Icelandic family with macroglogulinaemia. Acta Med. Scand. 211, 341–345.

    Article  PubMed  CAS  Google Scholar 

  34. Teitsson, I., Thorsteinsson, J., Arnason, A. and Valdimarsson, H. (1985) Rheumatic diseases in an Icelandic family. Scand. J. Rheumatol. 14, 109–118.

    Article  PubMed  CAS  Google Scholar 

  35. Palsdottir, A., Arnason, A., Fossdal, R. and Jensson, O. (1987) Gene organization of haplotypes expressing two different C4A allotypes. Hum. Genet. 76, 220–224.

    Article  PubMed  CAS  Google Scholar 

  36. Arnason, A., Thorsteinsson, J. and Sigurbergsson, K. (1978) Ankylosing spondylitis, HLA-B27 and Bf. Lancet. 1, 339–340.

    Article  PubMed  CAS  Google Scholar 

  37. Arnason, A., Helgason, T. and Jensson, O. (1979) HLA in insulin-dependent diabetes in Iceland. Icelandic Med. J. 4, 189–190.

    Google Scholar 

  38. Danielsen, R., Helgason, T., Arnason, A. and Jonasson, F. (1982) HLA and retinopathy in type 1 (insulin-dependent) diabetic patients in Iceland. Diabetologia 22, 297–298.

    Article  PubMed  CAS  Google Scholar 

  39. Arnason, A., Jensson, O., Skaftadottir, I., Birgisdottir, B., Gudmundsson, G. and Johanneson, G. (1980) HLA types, Gc protein and other genetic markers in multiple sclerosis and two other neurological diseases in Iceland. Acta Neurol. Scand. 62, 39–40.

    Google Scholar 

  40. Ulfarsson, J., Gudmundsson, S., Birgisdottir, B., Kjeld, M. J. and Jensson, O. (1982) Selective serum IgA deficiency in Icelanders: frequency, family studies and IgA levels. Acta Med. Scand. 211, 481–487.

    Article  PubMed  CAS  Google Scholar 

  41. Arnason, A., Jonmundsson, G. K., Skaftadottir, I., Thorsteinsson, L., Johannesson, G. M., Eyjolfsson, G., Fossdal, R., Petursdottir, I. and Jensson, O. (1985) Genetical markers and leukaemia in Iceland – an association between homozygosity of HLA B7, HLA B40 and leukaemia. Scand. J. Immunol. 22, 441.

    Article  Google Scholar 

  42. Tulinius, H., Day, N., Bjarnason, Ó., Geirsson, G., Jóhannesson, G., Conzales, M., Sigvaldason, H., Bjarnadóttir, G. and Grímsdóttir, K. (1982) Familial breast cancer in Iceland. Int. J. Cancer 29, 365–371.

    Article  PubMed  CAS  Google Scholar 

  43. Tulinius, H. Familial Risk of Breast Cancer in Iceland. In: Müller, Weber (eds.). Familial Cancer. 1st Int. Res. Conf., Basel 1985, p. 25–26 (Karger, Basel 1985).

    Google Scholar 

  44. Tulinius, H. Familial Cancer Registration in Iceland. In: Müller, Weber (eds.). Familial Cancer. 1st Int. Res. Conf., Basel 1985, p. 263–267 (Karger, Basel 1985).

    Google Scholar 

  45. Tryggvadóttir, L., Tulinius, H. and Robertson. J. M. (1988) Familial and sporadic breast cancer cases in Iceland: a comparison with respect to ABO blood groups and the risk of bilateral cancer of the breast. Int. J. Cancer 42, 499–501.

    Article  PubMed  Google Scholar 

  46. Tulinius, H., Egilsson, V., Olafsdottir, G. H. and Sigvaldason, H. (1992) Risque de cancer de la prostate, de l’ovaire et de l’endométre en cas d’antécédent familial de cancer du sein. le Journal International de Médecine 151, 25–28.

    Google Scholar 

  47. Tulinius, H., Olafsdottir, G. H., Sigvaldason, H., Tryggvadottir, L. and Bjarnadottir, K. (1994) Neoplastic diseases in families of breast cancer patients. J. Med. Genet. 31, 618–621.

    Article  PubMed  CAS  Google Scholar 

  48. Thorlacius, S., Tryggvadottir, L., Olafsdottir, G. H., Jonasson, J. G., Ogmundsdottir, H. M., Tulinius, H. and Eyfjord, J. E. (1995) Linkage to BRCA2 region in hereditary male breast cancer. Lancet 346, 544–545.

    Article  PubMed  CAS  Google Scholar 

  49. Tulinius, H. (1995) Impact of genetics on cancer. In: Parr, E., Næss, A. and Rossland, T: Kreftepidemiologi. Oslo 1995, 56–59.

    Google Scholar 

  50. Thorlacius, S., Olafsdóttir, G. H., Tryggvadóttir, L., Neuhausen, S., Jónasson, J. G., Tavigian, S. V., Tulinius, H., Ögmundsdóttir, H. M. and Eyfjörð, J. E. (1996) A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes. Nat. Genet. 13, 117–119.

    Article  PubMed  CAS  Google Scholar 

  51. Thorlacius, S., Sigurdsson, S., Bjarnadottir, H., Olafsdottir, G., Jonasson, J. G., Tryggvadottir, L., Tulinius, H. and Eyfjord, J. E. (1997) Study of a single BRCA2 mutation with high carrier frequency in a small population. Am. J. Hum. Genet. 60, 1079–1084.

    PubMed  CAS  Google Scholar 

  52. Thorlacius, S., Struewing, J. P., Hartge, P., Ólafsdóttir, G. H., Sigvaldason, H., Tryggvadóttir, L., Wacholder, S., Tulinius, H. and Eyfjörð, J. E. (1998) Population-based study of risk of breast cancer in carriers of BRCA2 mutation. Lancet 352, 1337–1339.

    Article  PubMed  CAS  Google Scholar 

  53. Tulinius, H., Sigvaldason, H., Ólafsdóttir, G., Tryggvadóttir, L. and Bjarnadóttir, K. (1999) Breast cancer incidence and familality in Iceland during 75 Years from 1921 to 1995. J. Med. Genet. 36, 103–107.

    PubMed  CAS  Google Scholar 

  54. Baffoe-Bonnie A., Beaty, T. H., Bailey-Wilson, J. E., Kiemeney, L., Sigvaldason, H., Ólafsdóttir, G., Tryggvadóttir, L. and Tulinius, H. (2000) Genetic epidemiology of breast cancer: segregation analysis of 389 icelandic pedigrees. Genet. Epidemiol. 18, 81–94.

    Article  PubMed  CAS  Google Scholar 

  55. Tulinius, H., Olafsdottir, G. H., Sigvaldason, H., Arason, A., Barkardottir, R. B., Egilsson, V., Ogmundsdottir, H. M., Tryggvadottir, L., Gudlaugsdottir, S. and Eyfjord, J. E. (2002) The effect of a single BRCA2 mutation on cancer in Iceland. J. Med. Genet. 39, 457–452.

    Article  PubMed  CAS  Google Scholar 

  56. Baffoe-Bonnie, A. B., Kiemeney, L. A. L. M., Beaty, T. H., Bailey-Wilson, J. E., Schnell, A. H., Sigvaldason, H., Ólafsdóttir, G., Tryggvadóttir, L. and Tulinius, H. (2002) Segregation analysis of 389 Icelandic pedigrees with breast and prostate cancer. Genet. Epidemiol. 23, 349–363.

    Article  PubMed  Google Scholar 

  57. Antoniou, A., Pharoah, P. D., Narod, S., Risch, H. A. et al. (2003) Averge risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysing of 22 studies. Am. J. Hum. Genet. 72, 5, 1117–1130.

    Article  PubMed  CAS  Google Scholar 

  58. Tryggvadottir, L., Olafsdottir, E. J., Gudlaugsdottir, S., Thorlacius, S., Jonasson, J. G., Tulinius, H. and Eyfjord, J. E. (2003) BRCA2 mutation carriers, reproductive factors and breast cancer risk. Breast Cancer Res. 5, 121–128. http://breast-cancer-research.com/content/5/5/R121

    Article  Google Scholar 

  59. Antoniou, A. C., Pharoah, P. D., Narod, S., Risch, H. A. et al. (2005) Breast and ovarian cancer risks to carriers of the BRCA1 1382insC and 185delAG and VRCA2 6174delT mutations: a combined analysis of 22 population based studies. J. Med. Genet. 42, 602–603.

    Article  PubMed  CAS  Google Scholar 

  60. Ögmundsdóttir, H., Haraldsdóttir, V., Jóhannesson, G. M., Ólafsdóttir, G., Bjarnadóttir, K., Sigvaldason, H. and Tulinius, H. (2005) Familiality of benign and malignant paraproteinemias. A population-based cancer-registry study of multiple myeloma families. Haematologica 90, 66–71.

    PubMed  Google Scholar 

  61. Tryggvadottir, L., Sigvaldason, H., Olafsdottir, G. H., Jonasson, J. G., Jonsson, T., Tulinius, H. and Eyfjord, J. E. (2006) Population-based study of changing breast cancer risk in Icelandic BRCA2 mutation carriers, 1920–2000. J. Natl. Cancer Inst. 98, 116–122.

    Article  PubMed  CAS  Google Scholar 

  62. Hrafnkelsson, J., Tulinius, H., Jonasson, J. G., Ólafsdóttir, G. and Sigvaldason, H. (1989) Papillary thyroid carcinoma in Iceland. A study of the occurrence in families and the coexistence of other primary tumours. Acta Oncologica 28, 785–758.

    Article  PubMed  CAS  Google Scholar 

  63. O´Neill, B. P., Blondal, H., Yang, P., Olafsdottir, G. H., Sigvaldason, H., Jenkins, R. B., Kimmel, D. W., Scheithauer, B. W., Rocca, W. A., Bjornsson, J. and Tulinius, H. (2002) Risk of cancer among relatives of patients with glioma. Cancer Epidemiol. Biomarkers Prev. 11, 921–924.

    Google Scholar 

  64. Eldon, B. J., Thorlacius, S., Jonsson, T., Jonasson, J. G., Kjartansson, J., Bodvarsson, S., Steingrimsson, E. and Rafnar, T. (2006) A population-based study on the familial aggregation of cutaneous malignant melanoma in Iceland. Eur. J. Cancer. 42, 922–926.

    Article  PubMed  Google Scholar 

  65. Stefansson, T., Moller, P. H., Sigurdsson, F., Steingrimsson, E. and Eldon B. J. (2006) Familial risk of colon and rectal cancer in Iceland: evidence for different etiologic factors? Int. J. Cancer. 119, 304–308.

    Article  PubMed  CAS  Google Scholar 

  66. Rafnar, T., Benediktsdottir, K. R., Eldon, B. J., Gestsson, T., Saemundsson, H., Olafsson, K., Salvarsdottir, A., Steingrimsson, E. and Thorlacius, S. (2004) BRCA2, but not BRCA1, mutations account for familial ovarian cancer in Iceland: a population-based study. Eur. J. Cancer. 40, 2788–2793.

    Article  PubMed  CAS  Google Scholar 

  67. Eldon, B. J., Jonsson, E., Tomasson, J., Tryggvadottir, L. and Tulinius, H. (2003) Familial risk of prostate cancer in Iceland. BJU Int. 92, 915–919.

    Article  PubMed  CAS  Google Scholar 

  68. Imsland, A. K., Eldon, B. J., Arinbjarnarson, S., Egilsson, V., Tulinius, H., Tryggvadottir, L., Arngrimsson, R. and Magnusson, J. (2002) Genetic epidemiologic aspects of gastric cancer in Iceland. J. Am. Coll. Surg. 195, 181–186; discussion: 186–187.

    Article  PubMed  Google Scholar 

  69. Andresdottir, M. B., Sigurdsson, G., Sigvaldason, H. and Gudnason, V. (2002) Fifteen percent of myocardial infarctions and coronary revascularizations explained by family history unrelated to conventional risk factors. Eur. Heart J. 23, 1655–1663.

    PubMed  CAS  Google Scholar 

  70. Tryggvadóttir, L., Vidarsdóttir, L., Thorgeirsson, J. G., Olafsdóttir, E. J., Olafsdóttir, G. H., Rafnar, T., Thorlacius, S., Jonsson, E., Eyfjord, J. E. and Tulinius, H. J. (2007) Prostate cancer progression and survival in BRCA2 mutation carriers. Natl Cancer Inst. Jun 20; 99(12), 929–935.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Genetical Committee of the University of Iceland, Reykjavik, Iceland

    Hrafn Tulinius

Authors
  1. Hrafn Tulinius
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hrafn Tulinius .

Editor information

Editors and Affiliations

  1. , Bio Banking and Molecular Resource, Karolinska Institutet, Stockholm, 205 02, Sweden

    Joakim Dillner

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Science+Business Media, LLC

About this protocol

Cite this protocol

Tulinius, H. (2011). Multigenerational Information: The Example of the Icelandic Genealogy Database. In: Dillner, J. (eds) Methods in Biobanking. Methods in Molecular Biology, vol 675. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59745-423-0_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-59745-423-0_11

  • Published:

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-58829-995-6

  • Online ISBN: 978-1-59745-423-0

  • eBook Packages: Springer Protocols

Publish with us

Policies and ethics

Search

Navigation