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Epigenetic Basis of Circadian Rhythm Disruption in Cancer

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Cancer Epigenetics for Precision Medicine

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1856))

Abstract

Self-sustained and synchronized to environmental stimuli, circadian clocks are under genetic and epigenetic regulation. Recent findings have greatly increased our understanding of epigenetic plasticity governed by circadian clock. Thus, the link between circadian clock and epigenetic machinery is reciprocal. Circadian clock can affect epigenetic features including genomic DNA methylation, noncoding RNA, mainly miRNA expression, and histone modifications resulted in their 24-h rhythms. Concomitantly, these epigenetic events can directly modulate cyclic system of transcription and translation of core circadian genes and indirectly clock output genes. Significant findings interlocking circadian clock, epigenetics, and cancer have been revealed, particularly in breast, colorectal, and blood cancers. Aberrant methylation of circadian gene promoter regions and miRNA expression affected circadian gene expression, together with 24-h expression oscillation pace have been frequently observed.

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Change history

  • 09 March 2019

    The Chapter was inadvertently published with incorrect figure (Fig. 1). The same has been corrected in the chapter.

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Authors and Affiliations

  1. Department of Molecular Genetics and Epigenetics, Nofer Institute of Occupational Medicine, Lodz, Poland

    Edyta Reszka

  2. Department of Biological and Chemical Work Environment, National Institute of Occupational Health, Oslo, Norway

    Shanbeh Zienolddiny

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  1. Edyta Reszka
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Correspondence to Edyta Reszka .

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  1. Kelly Government Solutions, Bethesda, MD, USA

    Ramona G. Dumitrescu

  2. Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Mukesh Verma

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Reszka, E., Zienolddiny, S. (2018). Epigenetic Basis of Circadian Rhythm Disruption in Cancer. In: Dumitrescu, R., Verma, M. (eds) Cancer Epigenetics for Precision Medicine . Methods in Molecular Biology, vol 1856. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8751-1_10

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