Abstract
Cardiogenic shock is one of the leading causes of death following acute myocardial infarction affecting 10% of patients with large myocardial infarcts with a subsequent mortality rate of 50%. Here we describe a large porcine model of acute ischemic cardiogenic shock. Acute left or right ventricular failure can be achieved with close to a 100% success rate by stepwise injection of microspheres into the left or right coronary artery, respectively, and the method allows for titration of heart failure to a prespecified level.
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Acknowledgments
We thank Dr. Janus A Hyldebrandt, Dr. Ann Banke, Dr. Charlotte Svejstrup Rud, Dr. Nanna Louise Junker Udesen, Dr. Henrik Schmidt, and Professor Lisette Okkels Jensen for their significant contributions to the experimental studies, enabling us to prepare this chapter.
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Møller-Helgestad, O.K., Ravn, H.B., Møller, J.E. (2018). Large Porcine Model of Profound Acute Ischemic Cardiogenic Shock. In: Ishikawa, K. (eds) Experimental Models of Cardiovascular Diseases. Methods in Molecular Biology, vol 1816. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8597-5_27
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DOI: https://doi.org/10.1007/978-1-4939-8597-5_27
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