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Mathematical Techniques for Understanding Platelet Regulation and the Development of New Pharmacological Approaches

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Platelets and Megakaryocytes

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1812))

Abstract

Mathematical and computational modeling is currently in the process of becoming an accepted tool in the arsenal of methods utilized for the investigation of complex biological systems. For some problems in the field, like cellular metabolic regulation, neural impulse propagation, or cell cycle, progress is already unthinkable without use of such methods. Mathematical models of platelet signaling, function, and metabolism during the last years have not only been steadily increasing in their number, but have also been providing more in-depth insights, generating hypotheses, and allowing predictions to be made leading to new experimental designs and data. Here we describe the basic approaches to platelet mathematical model development and validation, highlighting the challenges involved. We then review the current theoretical models in the literature and how these are being utilized to increase our understanding of these complex cells.

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Author information

Authors and Affiliations

  1. Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, UK

    Joanna L. Dunster & Jonathan M. Gibbins

  2. Faculty of Physics, Lomonosov Moscow State University, Moscow, Russia

    Mikhail A. Panteleev & Anastacia N. Sveshnikova

  3. Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow, Russia

    Mikhail A. Panteleev & Anastacia N. Sveshnikova

  4. National Scientific and Practical Centre of Pediatric Hematology, Oncology and Immunology Named After Dmitry Rogachev, Moscow, Russia

    Mikhail A. Panteleev & Anastacia N. Sveshnikova

  5. Faculty of Biological and Medical Physics, Moscow Institute of Physics and Technology, Dolgoprudnyi, Russia

    Mikhail A. Panteleev

Authors
  1. Joanna L. Dunster
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  2. Mikhail A. Panteleev
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  3. Jonathan M. Gibbins
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  4. Anastacia N. Sveshnikova
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Corresponding author

Correspondence to Joanna L. Dunster .

Editor information

Editors and Affiliations

  1. Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, Berkshire, UK

    Jonathan M. Gibbins

  2. Department of Molecular and Cell Biology, University of Leicester, Leicester, UK

    Martyn Mahaut-Smith

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Dunster, J.L., Panteleev, M.A., Gibbins, J.M., Sveshnikova, A.N. (2018). Mathematical Techniques for Understanding Platelet Regulation and the Development of New Pharmacological Approaches. In: Gibbins, J., Mahaut-Smith, M. (eds) Platelets and Megakaryocytes . Methods in Molecular Biology, vol 1812. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8585-2_15

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  • DOI: https://doi.org/10.1007/978-1-4939-8585-2_15

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8584-5

  • Online ISBN: 978-1-4939-8585-2

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