Abstract
Common terms used in statistical genetics with multiple meanings are explained and the terminology used in subsequent chapters is defined. Statistical human genetics has existed as a discipline for over a century, and during that time the meanings of many of the terms used have evolved, largely driven by molecular discoveries, to the point that molecular geneticists, statistical geneticists, and statisticians often have difficulty understanding each other. It is therefore imperative, now that so much of molecular genetics is becoming an in silico and statistical science, that we have a well-defined, common terminology.
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References
Gerstein MB et al (2007) What is a gene, post-ENCODE? History and updated definition. Genome Res 17:669–681
Ford EB (1940) Polymorphism and taxonomy. In: Huxley J (ed) The new systematics, Oxford University Press
Elston RC, Stewart J (1971) A general model for the genetic analysis of pedigree data. Hum Hered 21:523–542
Lewontin RC (1964) The interaction of selection and linkage. I. General considerations; heterotic models. Genetics 49:49–67
Wang X, Elston RC, Zhu X (2010) The meaning of interaction. Hum Hered 70:269–277
Wang X, Elston R, Zhu X (2010) Statistical interaction in human genetics: how should we model it if we are looking for biological interaction? Nat Rev Genet 12:74. doi:10.1038/nrg2579-c2
Ziegler A, König IR (2010) A statistical approach to genetic epidemiology: concepts and applications, 2nd edn. Wiley-VCH, Weinheim
Acknowledgments
This work was supported in part by the following grants from the National Institutes of Health, USA: P41RR003655 (RCE) and R01CA137420 (JMS).
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Elston, R.C., Satagopan, J., Sun, S. (2017). Statistical Genetic Terminology. In: Elston, R. (eds) Statistical Human Genetics. Methods in Molecular Biology, vol 1666. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7274-6_1
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DOI: https://doi.org/10.1007/978-1-4939-7274-6_1
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