Abstract
Natural antibodies have diverse functions in maintaining immune homeostasis and in the regulation of autoimmune response. Yet there might be other important functions of natural antibodies for human medicine such as the ability of natural antibodies to shape and induce antibody immune responses. I propose that natural antibodies, present in IVIG, could be used to prevent autoimmune reactions and to enhance the immune response to vaccination.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Boes M (2000) Role of natural and immune IgM antibodies in immune responses. Mol Immunol 37:1141–1149
Bushby K, Finkel R, Birnkrant DJ, Case LE, Clemens PR, Cripe L et al (2010) Diagnosis and management of Duchenne muscular dystrophy, part 2: implementation of multidisciplinary care. Lancet Neurol 9:177–189. doi:10.1016/S1474-4422(09)70272-8
Kohler H, Bayry J, Kaveri SV (2016) The homophilic domain - an immunological archetype. Front Immunol 7:106. doi:10.3389/fimmu.2016.00106
Banikazemi M, Bultas J, Waldek S, Wilcox WR, Whitley CB, McDonald M et al (2007) Agalsidase-beta therapy for advanced Fabry disease: a randomized trial. Ann Intern Med 146:77–86
Elluru SR, Kaveri SV, Bayry J (2015) The protective role of immunoglobulins in fungal infections and inflammation. Semin Immunopathol 37:187–197. doi:10.1007/s00281-014-0466-0
Briles DE, Forman C, Hudak S, Claflin JL (1982) Anti-phosphorylcholine antibodies of the T15 idiotype are optimally protective against streptococcus pneumonia. J Exp Med 156:1177–1185
Avrameas S (1991) Natural autoantibodies: from 'horror autotoxicus' to 'gnothi seauton'. Immunol Today 12:154–159
Kyaw T, Tay C, Krishnamurthi S, Kanellakis P, Agrotis A, Tipping P et al (2011) B1a B lymphocytes are atheroprotective by secreting natural IgM that increases IgM deposits and reduces necrotic cores in atherosclerotic lesions. Circ Res 109:830–840. doi:10.1161/CIRCRESAHA.111.248542
Kaveri SV, Silverman GJ, Bayry J (2012) Natural IgM in immune equilibrium and harnessing their therapeutic potential. J Immunol 188:939–945. doi:10.4049/jimmunol.1102107
Gilardin L, Bayry J, Kaveri SV (2015) Intravenous immunoglobulin as clinical immune-modulating therapy. CMAJ 187:257–264. doi:10.1503/cmaj.130375
Kohler H, Bayry J, Nicoletti A, Kaveri SV (2003) Natural autoantibodies as tools to predict the outcome of immune response? Scand J Immunol 58:285–289. doi:10.1046/j.1365-3083.2003.01314.x
Lieberman R, Potter M, Mushinski EB, Humphrey W Jr, Rudikoff S (1974) Genetics of a new IgVH (T15 idiotype) marker in the mouse regulating natural antibody to phosphorylcholine. J Exp Med 139:983–1001
Fung J, Kohler H (1980) Late clonal selection and expansion of the TEPC-15 germ-line specificity. J Exp Med 152:1262–1273
Tsuji RF, Szczepanik M, Kawikova I, Paliwal V, Campos RA, Itakura A et al (2002) B cell-dependent T cell responses: IgM antibodies are required to elicit contact sensitivity. J Exp Med 196:1277–1290
Jerne NK (1974) Towards a network theory of the immune system. Ann Immunol (Paris) 125C:373–389
Jerne NK, Roland J, Cazenave PA (1982) Recurrent idiotopes and internal images. EMBO J 1:243–247
Lunemann JD, Nimmerjahn F, Dalakas MC (2015) Intravenous immunoglobulin in neurology–mode of action and clinical efficacy. Nat Rev Neurol 11:80–89. doi:10.1038/nrneurol.2014.253
Gelfand EW (2012) Intravenous immune globulin in autoimmune and inflammatory diseases. N Engl J Med 367:2015–2025. doi:10.1056/NEJMra1009433
Galeotti C, Kaveri SV, Bayry J (2015) Molecular and immunological biomarkers to predict IVIg response. Trends Mol Med 21:145–147. doi:10.1016/j.molmed.2015.01.005
Bayry J, Hartung HP, Kaveri SV (2015) IVIg for relapsing-remitting multiple sclerosis: promises and uncertainties. Trends Pharmacol Sci 36:419–421. doi:10.1016/j.tips.2015.04.012
Sanchez-Ramon S, Dhalla F, Chapel H (2016) Challenges in the role of gammaglobulin replacement therapy and vaccination strategies for hematological malignancy. Front Immunol 7:317. doi:10.3389/fimmu.2016.00317
Shopsin B, Kaveri SV, Bayry J (2016) Tackling difficult Staphylococcus aureus infections: antibodies show the way. Cell Host Microbe 20:555–557. doi:10.1016/j.chom.2016.10.018
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer Science+Business Media LLC
About this protocol
Cite this protocol
Kohler, H. (2017). Natural Antibodies: Next Steps Toward Translational Investigation. In: Kaveri, S., Bayry, J. (eds) Natural Antibodies. Methods in Molecular Biology, vol 1643. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7180-0_1
Download citation
DOI: https://doi.org/10.1007/978-1-4939-7180-0_1
Published:
Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-7179-4
Online ISBN: 978-1-4939-7180-0
eBook Packages: Springer Protocols