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Functional Network in Posttranslational Modifications: Glyco-Net in Glycoconjugate Data Bank

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Glycoinformatics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1273))

Abstract

Elucidating pathways related to posttranslational modifications (PTMs) such as glycosylation is of growing importance in post-genome science and technology. Graphical networks describing the relationships among glycan-related molecules, including genes, proteins, lipids, and various biological events, are considered extremely valuable and convenient tools for the systematic investigation of PTMs. Glyco-Net (http://bibi.sci.hokudai.ac.jp/functions/) can dynamically make network figures among various biological molecules and biological events. A certain molecule or event is expressed with a node, and the relationship between the molecule and the event is indicated by arrows in the network figures. In this chapter, we mention the features and current status of the Glyco-Net and a simple example of the search with the Glyco-Net.

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Acknowledgment

This work was supported in part by the Program of Founding Research Centers for Emerging and Reemerging Infectious Diseases and Grants-in-Aid for Regional R&D Proposal-Based Program from Northern Advancement Center for Science & Technology of Hokkaido Japan. The authors also thank Ms. Chikage Chikaoka and Dr. Yasuko Tanaka for their dedicated help in the curation of the data. The authors thank Professor Shin-Ichiro Nishimura for helpful discussion.

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Authors and Affiliations

  1. Graduate School of Life Sciences, Hokkaido University, 1-204, Open Laboratory in Central Campus, Sapporo, 060-0812, Japan

    Nobuaki Miura

  2. Center for Informational Biology, Ochanomizu University, 2-1-1 Ohtsuka, Bunkyo-ku, Tokyo, 112-8610, Japan

    Nobuaki Miura

  3. Science & Technology Systems, Inc., 5-1-16 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

    Takuya Okada, Daisuke Murayama, Ryo Hashimoto & Nobuhiro Fukushima

  4. Hokkaido STS, Inc., 5-1-16 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

    Kazuko Hirose, Taku Sato & Nobuhiro Fukushima

Authors
  1. Nobuaki Miura
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  2. Takuya Okada
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  3. Daisuke Murayama
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  4. Kazuko Hirose
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  5. Taku Sato
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  6. Ryo Hashimoto
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  7. Nobuhiro Fukushima
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Corresponding author

Correspondence to Nobuaki Miura .

Editor information

Editors and Affiliations

  1. Justus-Liebig-University, Giessen, Germany

    Thomas Lütteke

  2. Biognos AB, Göteborg, Sweden

    Martin Frank

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Miura, N. et al. (2015). Functional Network in Posttranslational Modifications: Glyco-Net in Glycoconjugate Data Bank. In: Lütteke, T., Frank, M. (eds) Glycoinformatics. Methods in Molecular Biology, vol 1273. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2343-4_11

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  • DOI: https://doi.org/10.1007/978-1-4939-2343-4_11

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-2342-7

  • Online ISBN: 978-1-4939-2343-4

  • eBook Packages: Springer Protocols

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