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Capacitating Epistasis—Detection and Role in the Genetic Architecture of Complex Traits

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Epistasis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1253))

Abstract

Here, we discuss the potential role of capacitating epistasis in the genetic architecture of complex traits. Two alternative methods for identifying such gene-gene interactions in genetic association studies—mapping of variance controlling loci and the variance plane ratio (VPR) method—are introduced. An overview of the theoretical foundation of the methods is presented together with a discussion on their implementation and available software for performing these analyses. We conclude by highlighting a few examples of capacitating epistasis described in the literature and its potential impacts on the genetics of complex traits.

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Author information

Authors and Affiliations

  1. Division of Computational Genetics, Department of Clinical Sciences, Swedish University of Agricultural Sciences, Box 7078, SE-750 07, Uppsala, Sweden

    Mats E. Pettersson & Örjan Carlborg

Authors
  1. Mats E. Pettersson
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  2. Örjan Carlborg
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Corresponding author

Correspondence to Örjan Carlborg .

Editor information

Editors and Affiliations

  1. Department of Genetics, Institute of Quantitative Biomedical Sciences, Geisel School of Medicine, Hanover, New Hampshire, USA

    Jason H. Moore

  2. Department of Genetics, Institute of Quantitative Biomedical Sciences, Geisel School of Medicine, Hanover, New Hampshire, USA

    Scott M. Williams

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Pettersson, M.E., Carlborg, Ö. (2015). Capacitating Epistasis—Detection and Role in the Genetic Architecture of Complex Traits. In: Moore, J., Williams, S. (eds) Epistasis. Methods in Molecular Biology, vol 1253. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2155-3_10

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  • DOI: https://doi.org/10.1007/978-1-4939-2155-3_10

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-2154-6

  • Online ISBN: 978-1-4939-2155-3

  • eBook Packages: Springer Protocols

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