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Psychophysiology of Sleep

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Psychophysiology Methods

Part of the book series: Neuromethods ((NM,volume 206))

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Abstract

Sleep is a complex behavior, neurophysiological, psychological, and neurochemical phenomenon, which shows striking phylogenetic and ontogenetic changes. Among its numerous and vital functions, research has identified energy conservation, brain waste clearance, immune response modulation, development, learning, cognition, optimal performance, recovery from disease, modulation of vigilance, and several other mental/psychological processes. This chapter provides a condensed overview of the normal and pathological human sleep, and of the main neurophysiological tool (polysomnography) that has been for decades the gold standard for its study. This chapter is intended as an introduction to this complex and fascinating topic, especially in the field of Psychophysiology, and provides a basis for needed future research combining the “physical” and “psychic” aspects of sleep, especially concerning the origin of sleep and its stages, as well as the psychophysiological characteristics of normal sleep and their changes occurring in sleep disorders.

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References

  1. Krueger JM, Frank MG, Wisor JP, Roy S (2016) Sleep function: toward elucidating an enigma. Sleep Med Rev 28:46–54. https://doi.org/10.1016/j.smrv.2015.08.005

    Article  PubMed  Google Scholar 

  2. Berry RB, Quan SF, Abreu AR, Bibbs ML, DelRosso L, Harding SM, Mao M-M, Plante DT, Pressman MR, Troester MR, Vaughn BV, For the American Academy of Sleep Medicine (2020) The AASM manual for the scoring of Sleep and associated events: rules, terminology and technical specifications, Ver. 2.6. American Academy of Sleep Medicine, Darien

    Google Scholar 

  3. Rechtschaffen A, Kales A (1968) A manual of standardized terminology, techniques, and scoring system for Sleep stages of human subjects. Washington Public Health service/US Government Printing Office, Washington

    Google Scholar 

  4. Danker-Hopfe H, Anderer P, Zeitlhofer J, Boeck M, Dorn H, Gruber G, Heller E, Loretz E, Moser D, Parapatics S, Saletu B, Schmidt A, Dorffner G (2009) Interrater reliability for sleep scoring according to the Rechtschaffen & Kales and the new AASM standard. JSleep Res 18(1):74–84

    Article  Google Scholar 

  5. Novelli L, Ferri R, Bruni O (2010) Sleep classification according to AASM and Rechtschaffen and Kales: effects on sleep scoring parameters of children and adolescents. J Sleep Res 19(1 Pt 2):238–247. https://doi.org/10.1111/j.1365-2869.2009.00785.x

    Article  PubMed  Google Scholar 

  6. Yeo SS, Chang PH, Jang SH (2013) The ascending reticular activating system from pontine reticular formation to the thalamus in the human brain. Front Hum Neurosci 7:416. https://doi.org/10.3389/fnhum.2013.00416

    Article  PubMed  PubMed Central  Google Scholar 

  7. Garcia-Rill E, Luster B, D’Onofrio S, Mahaffey S, Bisagno V, Urbano FJ (2016) Implications of gamma band activity in the pedunculopontine nucleus. J Neural Transm (Vienna) 123(7):655–665. https://doi.org/10.1007/s00702-015-1485-2

    Article  CAS  PubMed  Google Scholar 

  8. Fuller PM, Sherman D, Pedersen NP, Saper CB, Lu J (2011) Reassessment of the structural basis of the ascending arousal system. J Comp Neurol 519(5):933–956. https://doi.org/10.1002/cne.22559

    Article  PubMed  PubMed Central  Google Scholar 

  9. Bosinelli M (1995) Mind and consciousness during sleep. Behav Brain Res 69(1–2):195–201. https://doi.org/10.1016/0166-4328(95)00003-c

    Article  CAS  PubMed  Google Scholar 

  10. Coslett HB (1997) Consciousness and attention. Semin Neurol 17(2):137–144. https://doi.org/10.1055/s-2008-1040923

    Article  CAS  PubMed  Google Scholar 

  11. Kirszenblat L, van Swinderen B (2015) The yin and Yang of Sleep and attention. Trends Neurosci 38(12):776–786. https://doi.org/10.1016/j.tins.2015.10.001

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Coenen A (2012) Modelling of auditory evoked potentials of human sleep-wake states. Int J Psychophysiol 85(1):37–40. https://doi.org/10.1016/j.ijpsycho.2011.10.010

    Article  PubMed  Google Scholar 

  13. Paller KA, Creery JD, Schechtman E (2021) Memory and Sleep: how Sleep cognition can change the waking mind for the better. Annu Rev Psychol 72:123–150. https://doi.org/10.1146/annurev-psych-010419-050815

    Article  PubMed  Google Scholar 

  14. Wassing R, Lakbila-Kamal O, Ramautar JR, Stoffers D, Schalkwijk F, Van Someren EJW (2019) Restless REM sleep impedes overnight amygdala adaptation. Curr Biol 29(14):2351–2358. https://doi.org/10.1016/j.cub.2019.06.034

    Article  CAS  PubMed  Google Scholar 

  15. Fazekas P, Nemeth G (2020) Dreaming, mind-wandering, and hypnotic dreams. Front Neurol 11:565673. https://doi.org/10.3389/fneur.2020.565673

    Article  PubMed  PubMed Central  Google Scholar 

  16. Scarpelli S, Bartolacci C, D’Atri A, Gorgoni M, De Gennaro L (2019) Mental sleep activity and disturbing dreams in the lifespan. Int J Environ Res Public Health 16(19). https://doi.org/10.3390/ijerph16193658

  17. American Academy of Sleep Medicine (ed) (2014) International classification of sleep disorders, 3rd edn. American Academy of Sleep Medicine, Darien

    Google Scholar 

  18. Bruni O, DelRosso LM, Mogavero MP, Angriman M, Ferri R (2022) Chronic insomnia of early childhood: phenotypes and pathophysiology. Neurosci Biobehav Rev 137:104653. https://doi.org/10.1016/j.neubiorev.2022.104653

    Article  CAS  PubMed  Google Scholar 

  19. Riemann D, Baglioni C, Bassetti C, Bjorvatn B, Dolenc Groselj L, Ellis JG, Espie CA, Garcia-Borreguero D, Gjerstad M, Goncalves M, Hertenstein E, Jansson-Frojmark M, Jennum PJ, Leger D, Nissen C, Parrino L, Paunio T, Pevernagie D, Verbraecken J, Weess HG, Wichniak A, Zavalko I, Arnardottir ES, Deleanu OC, Strazisar B, Zoetmulder M, Spiegelhalder K (2017) European guideline for the diagnosis and treatment of insomnia. J Sleep Res 26(6):675–700. https://doi.org/10.1111/jsr.12594

    Article  PubMed  Google Scholar 

  20. Dopheide JA (2020) Insomnia overview: epidemiology, pathophysiology, diagnosis and monitoring, and nonpharmacologic therapy. Am J Manag Care 26(4 Suppl):S76–S84. https://doi.org/10.37765/ajmc.2020.42769

    Article  PubMed  Google Scholar 

  21. Boivin DB, Boudreau P (2014) Impacts of shift work on sleep and circadian rhythms. Pathol Biol 62(5):292–301. https://doi.org/10.1016/j.patbio.2014.08.001

    Article  CAS  PubMed  Google Scholar 

  22. Thomas JH, Burgers DE (2018) Sleep is an eye-opener: behavioral causes and consequences of hypersomnolence in children. Paediatr Respir Rev 25:3–8. https://doi.org/10.1016/j.prrv.2016.11.004

    Article  PubMed  Google Scholar 

  23. Smolensky MH, Sackett-Lundeen LL, Portaluppi F (2015) Nocturnal light pollution and underexposure to daytime sunlight: complementary mechanisms of circadian disruption and related diseases. Chronobiol Int 32(8):1029–1048. https://doi.org/10.3109/07420528.2015.1072002

    Article  PubMed  Google Scholar 

  24. Covassin N, Singh P (2016) Sleep duration and cardiovascular disease risk: epidemiologic and experimental evidence. Sleep Med Clin 11(1):81–89. https://doi.org/10.1016/j.jsmc.2015.10.007

    Article  PubMed  PubMed Central  Google Scholar 

  25. Mogavero MP, DelRosso LM, Fanfulla F, Bruni O, Ferri R (2020) Sleep disorders and cancer: state of the art and future perspectives. Sleep Med Rev 56:101409. https://doi.org/10.1016/j.smrv.2020.101409

    Article  PubMed  Google Scholar 

  26. Irwin MR, Olmstead R, Carroll JE (2016) Sleep disturbance, Sleep duration, and inflammation: a systematic review and meta-analysis of cohort studies and experimental Sleep deprivation. Biol Psychiatry 80(1):40–52. https://doi.org/10.1016/j.biopsych.2015.05.014

    Article  PubMed  Google Scholar 

  27. Bliwise DL, Scullin MK (2018) Sleep and cognition. In: Cappuccio FP, Miller MA, Lockley SW, Rajaratnam SMW (eds) Sleep, health, and society: from aetiology to public health. Oxford University Press, Oxford. https://doi.org/10.1093/oso/9780198778240.003.0004

    Chapter  Google Scholar 

  28. Gaine ME, Chatterjee S, Abel T (2018) Sleep deprivation and the epigenome. Frontiers in neural circuits 12:14. https://doi.org/10.3389/fncir.2018.00014

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Roberts RE, Duong HT (2014) The prospective association between sleep deprivation and depression among adolescents. Sleep 37(2):239–244. https://doi.org/10.5665/sleep.3388

    Article  PubMed  PubMed Central  Google Scholar 

  30. Bayon V, Leger D, Gomez-Merino D, Vecchierini MF, Chennaoui M (2014) Sleep debt and obesity. Ann Med 46(5):264–272. https://doi.org/10.3109/07853890.2014.931103

    Article  PubMed  Google Scholar 

  31. Ferini-Strambi L, Auer R, Bjorvatn B, Castronovo V, Franco O, Gabutti L, Galbiati A, Hajak G, Khatami R, Kitajima T, McEvoy D, Nissen C, Perlis M, Pevernagie DA, Randerath W, Riemann D, Rizzo G, Van Someren E, Vgontzas A, Barazzoni F, Bassetti C, European Sleep F (2021) Insomnia disorder: clinical and research challenges for the 21st century. Eur J Neurol 28(7):2156–2167. https://doi.org/10.1111/ene.14784

    Article  PubMed  Google Scholar 

  32. Kim JH, Duffy JF (2018) Circadian rhythm Sleep-wake disorders in older adults. Sleep Med Clin 13(1):39–50. https://doi.org/10.1016/j.jsmc.2017.09.004

    Article  PubMed  Google Scholar 

  33. Pavlova M (2017) Circadian rhythm Sleep-wake disorders. Continuum: Lifelong Learning in Neurology 23(4):1051–1063. https://doi.org/10.1212/CON.0000000000000499

    Article  PubMed  Google Scholar 

  34. Tedjasukmana R (2022) Sleep disturbances linked to genetic disorders. Sleep Med Clin 17(1):77–86. https://doi.org/10.1016/j.jsmc.2021.10.005

    Article  PubMed  Google Scholar 

  35. Mohawk JA, Green CB, Takahashi JS (2012) Central and peripheral circadian clocks in mammals. Annu Rev Neurosci 35:445–462. https://doi.org/10.1146/annurev-neuro-060909-153128

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Salemi M, Mogavero MP, Lanza G, Mongioi LM, Calogero AE, Ferri R (2022) Examples of inverse comorbidity between cancer and neurodegenerative diseases: a possible role for noncoding RNA. Cell 11(12). https://doi.org/10.3390/cells11121930

  37. Tahkamo L, Partonen T, Pesonen AK (2019) Systematic review of light exposure impact on human circadian rhythm. Chronobiol Int 36(2):151–170. https://doi.org/10.1080/07420528.2018.1527773

    Article  PubMed  Google Scholar 

  38. Wahl S, Engelhardt M, Schaupp P, Lappe C, Ivanov IV (2019) The inner clock-blue light sets the human rhythm. J Biophotonics 12(12):e201900102. https://doi.org/10.1002/jbio.201900102

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Publishing, Arlington

    Book  Google Scholar 

  40. Bruni O, DelRosso LM, Melegari MG, Ferri R (2021) The parasomnias. Child Adolesc Psychiatr Clin N Am 30(1):131–142. https://doi.org/10.1016/j.chc.2020.08.007

    Article  PubMed  Google Scholar 

  41. Idir Y, Oudiette D, Arnulf I (2022) Sleepwalking, sleep terrors, sexsomnia and other disorders of arousal: the old and the new. J Sleep Res 31(4):e13596. https://doi.org/10.1111/jsr.13596

    Article  PubMed  Google Scholar 

  42. Erickson J, Vaughn BV (2019) Non-REM parasomnia: the promise of precision medicine. Sleep Med Clin 14(3):363–370. https://doi.org/10.1016/j.jsmc.2019.05.002

    Article  PubMed  Google Scholar 

  43. Laberge L, Tremblay RE, Vitaro F, Montplaisir J (2000) Development of parasomnias from childhood to early adolescence. Pediatrics 106(1 Pt 1):67–74. https://doi.org/10.1542/peds.106.1.67

    Article  CAS  PubMed  Google Scholar 

  44. Castelnovo A, Lopez R, Proserpio P, Nobili L, Dauvilliers Y (2018) NREM sleep parasomnias as disorders of sleep-state dissociation. Nat Rev Neurol 14(8):470–481. https://doi.org/10.1038/s41582-018-0030-y

    Article  PubMed  Google Scholar 

  45. Bassetti C, Vella S, Donati F, Wielepp P, Weder B (2000) SPECT during sleepwalking. Lancet 356(9228):484–485. https://doi.org/10.1016/S0140-6736(00)02561-7

    Article  CAS  PubMed  Google Scholar 

  46. Lanza G, DelRosso LM, Ferri R (2022) Sleep and homeostatic control of plasticity. Handb Clin Neurol 184:53–72. https://doi.org/10.1016/B978-0-12-819410-2.00004-7

    Article  PubMed  Google Scholar 

  47. Hublin C, Kaprio J (2003) Genetic aspects and genetic epidemiology of parasomnias. Sleep Med Rev 7(5):413–421. https://doi.org/10.1053/smrv.2001.0247

    Article  PubMed  Google Scholar 

  48. Simon SL, Byars KC (2016) Behavioral treatments for non-rapid eye movement parasomnias in children. Current sleep medicine reports 2(3):152–157. https://doi.org/10.1007/s40675-016-0049-9

    Article  Google Scholar 

  49. Kotagal S (2012) Treatment of dyssomnias and parasomnias in childhood. Curr Treat Options Neurol 14(6):630–649. https://doi.org/10.1007/s11940-012-0199-0

    Article  PubMed  Google Scholar 

  50. Bruni O, Ferri R, Miano S, Verrillo E (2004) L -5-Hydroxytryptophan treatment of sleep terrors in children. Eur J Pediatr 163(7):402–407. https://doi.org/10.1007/s00431-004-1444-7

    Article  CAS  PubMed  Google Scholar 

  51. Howell MJ (2012) Parasomnias: an updated review. Neurotherapeutics 9(4):753–775. https://doi.org/10.1007/s13311-012-0143-8

    Article  PubMed  PubMed Central  Google Scholar 

  52. Stefani A, Holzknecht E, Hogl B (2019) Clinical neurophysiology of REM parasomnias. Handb Clin Neurol 161:381–396. https://doi.org/10.1016/B978-0-444-64142-7.00062-X

    Article  PubMed  Google Scholar 

  53. Peever J, Luppi PH, Montplaisir J (2014) Breakdown in REM sleep circuitry underlies REM sleep behavior disorder. Trends Neurosci 37(5):279–288. https://doi.org/10.1016/j.tins.2014.02.009

    Article  CAS  PubMed  Google Scholar 

  54. Lanza G, Arico D, Lanuzza B, Cosentino FII, Tripodi M, Giardina F, Bella R, Puligheddu M, Pennisi G, Ferri R, Pennisi M (2020) Facilitatory/inhibitory intracortical imbalance in REM sleep behavior disorder: early electrophysiological marker of neurodegeneration? Sleep 43(3). https://doi.org/10.1093/sleep/zsz242

  55. Figorilli M, Lanza G, Congiu P, Lecca R, Casaglia E, Mogavero MP, Puligheddu M, Ferri R (2021) Neurophysiological aspects of REM sleep behavior disorder (RBD): a narrative review. Brain Sci 11(12). https://doi.org/10.3390/brainsci11121588

  56. Lanza G, Cosentino FII, Lanuzza B, Tripodi M, Arico D, Figorilli M, Puligheddu M, Fisicaro F, Bella R, Ferri R, Pennisi M (2022) Reduced intracortical facilitation to TMS in both isolated REM sleep behavior disorder (RBD) and early Parkinson’s disease with RBD. J Clin Med 11(9). https://doi.org/10.3390/jcm11092291

  57. Kotagal S (2015) Rapid eye movement sleep behavior disorder during childhood. Sleep Med Clin 10(2):163–167. https://doi.org/10.1016/j.jsmc.2015.02.004

    Article  PubMed  Google Scholar 

  58. Zadra A, Donderi DC (2000) Nightmares and bad dreams: their prevalence and relationship to Well-being. J Abnorm Psychol 109(2):273–281

    Article  CAS  PubMed  Google Scholar 

  59. Sandor P, Szakadat S, Bodizs R (2014) Ontogeny of dreaming: a review of empirical studies. Sleep Med Rev 18(5):435–449. https://doi.org/10.1016/j.smrv.2014.02.001

    Article  PubMed  Google Scholar 

  60. Baumann CR, Bassetti CL (2005) Hypocretins (orexins) and sleep-wake disorders. The Lancet Neurology 4(10):673–682. https://doi.org/10.1016/S1474-4422(05)70196-4

    Article  CAS  PubMed  Google Scholar 

  61. Bassetti CLA, Adamantidis A, Burdakov D, Han F, Gay S, Kallweit U, Khatami R, Koning F, Kornum BR, Lammers GJ, Liblau RS, Luppi PH, Mayer G, Pollmacher T, Sakurai T, Sallusto F, Scammell TE, Tafti M, Dauvilliers Y (2019) Narcolepsy – clinical spectrum, aetiopathophysiology, diagnosis and treatment. Nat Rev Neurol 15(9):519–539. https://doi.org/10.1038/s41582-019-0226-9

    Article  PubMed  Google Scholar 

  62. Postiglione E, Antelmi E, Pizza F, Lecendreux M, Dauvilliers Y, Plazzi G (2018) The clinical spectrum of childhood narcolepsy. Sleep Med Rev 38:70–85. https://doi.org/10.1016/j.smrv.2017.04.003

    Article  PubMed  Google Scholar 

  63. Latorre D, Kallweit U, Armentani E, Foglierini M, Mele F, Cassotta A, Jovic S, Jarrossay D, Mathis J, Zellini F, Becher B, Lanzavecchia A, Khatami R, Manconi M, Tafti M, Bassetti CL, Sallusto F (2018) T cells in patients with narcolepsy target self-antigens of hypocretin neurons. Nature 562(7725):63–68. https://doi.org/10.1038/s41586-018-0540-1

    Article  CAS  PubMed  Google Scholar 

  64. Baumann-Vogel H, Schreckenbauer L, Valko PO, Werth E, Baumann CR (2021) Narcolepsy type 2: a rare, yet existing entity. J Sleep Res 30(3):e13203. https://doi.org/10.1111/jsr.13203

    Article  PubMed  Google Scholar 

  65. Arnulf I, Leu-Semenescu S, Dodet P (2019) Precision medicine for idiopathic hypersomnia. Sleep Med Clin 14(3):333–350. https://doi.org/10.1016/j.jsmc.2019.05.007

    Article  PubMed  Google Scholar 

  66. Materna L, Halfter H, Heidbreder A, Boentert M, Lippert J, Koch R, Young P (2018) Idiopathic hypersomnia patients revealed longer circadian period length in peripheral skin fibroblasts. Front Neurol 9:424. https://doi.org/10.3389/fneur.2018.00424

    Article  PubMed  PubMed Central  Google Scholar 

  67. Arnulf I (2015) Kleine-Levin Syndrome. Sleep Med Clin 10(2):151–161. https://doi.org/10.1016/j.jsmc.2015.02.001

    Article  PubMed  Google Scholar 

  68. Afolabi-Brown O, Mason TBA 2nd (2018) Kleine-Levin Syndrome. Paediatr Respir Rev 25:9–13. https://doi.org/10.1016/j.prrv.2016.12.004

    Article  PubMed  Google Scholar 

  69. Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW, Zucconi M, Ferri R, Trenkwalder C, Lee HB, International Restless Legs Syndrome Study G (2014) Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria–history, rationale, description, and significance. Sleep Med 15(8):860–873. https://doi.org/10.1016/j.sleep.2014.03.025

    Article  PubMed  Google Scholar 

  70. Jimenez-Jimenez FJ, Alonso-Navarro H, Garcia-Martin E, Agundez JAG (2018) Genetics of restless legs syndrome: an update. Sleep Med Rev 39:108–121. https://doi.org/10.1016/j.smrv.2017.08.002

    Article  PubMed  Google Scholar 

  71. Trenkwalder C, Allen R, Hogl B, Clemens S, Patton S, Schormair B, Winkelmann J (2018) Comorbidities, treatment, and pathophysiology in restless legs syndrome. The Lancet Neurology 17(11):994–1005. https://doi.org/10.1016/S1474-4422(18)30311-9

    Article  CAS  PubMed  Google Scholar 

  72. Clemens S, Rye D, Hochman S (2006) Restless legs syndrome: revisiting the dopamine hypothesis from the spinal cord perspective. Neurology 67(1):125–130. https://doi.org/10.1212/01.wnl.0000223316.53428.c9

    Article  PubMed  Google Scholar 

  73. Mogavero MP, Mezzapesa DM, Savarese M, DelRosso LM, Lanza G, Ferri R (2021) Morphological analysis of the brain subcortical gray structures in restless legs syndrome. Sleep Med 88:74–80. https://doi.org/10.1016/j.sleep.2021.10.025

    Article  PubMed  Google Scholar 

  74. Rizzo G, Plazzi G (2018) Neuroimaging applications in restless legs syndrome. Int Rev Neurobiol 143:31–64. https://doi.org/10.1016/bs.irn.2018.09.012

    Article  PubMed  Google Scholar 

  75. Tuovinen N, Stefani A, Mitterling T, Heidbreder A, Frauscher B, Gizewski ER, Poewe W, Hogl B, Scherfler C (2021) Functional connectivity and topology in patients with restless legs syndrome: a case-control resting-state functional magnetic resonance imaging study. Eur J Neurol 28(2):448–458. https://doi.org/10.1111/ene.14577

    Article  CAS  PubMed  Google Scholar 

  76. Lanza G, Lanuzza B, Arico D, Cantone M, Cosentino FI, Pennisi M, Bella R, Pennisi G, Ferri R (2016) Response to the letter to the editor “cortical excitability in restless legs syndrome”. Sleep Med 21:175. https://doi.org/10.1016/j.sleep.2015.09.002

    Article  PubMed  Google Scholar 

  77. Lanza G (2020) Repetitive TMS for sleep disorders: are we ready? Sleep Med 71:111–112. https://doi.org/10.1016/j.sleep.2020.03.001

    Article  PubMed  Google Scholar 

  78. Cantone M, Lanza G, Ranieri F, Opie GM, Terranova C (2021) Editorial: non-invasive brain stimulation in the study and modulation of Metaplasticity in neurological disorders. Front Neurol 12:721906. https://doi.org/10.3389/fneur.2021.721906

    Article  PubMed  PubMed Central  Google Scholar 

  79. Lanza G, Scalise A (2020) The present and the future of transcranial magnetic stimulation in restless legs syndrome. Sleep Med 71:122–123. https://doi.org/10.1016/j.sleep.2020.02.002

    Article  PubMed  Google Scholar 

  80. Hornyak M, Feige B, Riemann D, Voderholzer U (2006) Periodic leg movements in sleep and periodic limb movement disorder: prevalence, clinical significance and treatment. Sleep Med Rev 10(3):169–177. https://doi.org/10.1016/j.smrv.2005.12.003

    Article  PubMed  Google Scholar 

  81. Haba-Rubio J, Marti-Soler H, Marques-Vidal P, Tobback N, Andries D, Preisig M, Waeber G, Vollenweider P, Kutalik Z, Tafti M, Heinzer R (2016) Prevalence and determinants of periodic limb movements in the general population. Ann Neurol 79(3):464–474. https://doi.org/10.1002/ana.24593

    Article  PubMed  Google Scholar 

  82. Kirk VG, Bohn S (2004) Periodic limb movements in children: prevalence in a referred population. Sleep 27(2):313–315. https://doi.org/10.1093/sleep/27.2.313

    Article  PubMed  Google Scholar 

  83. Delrosso LM, Lockhart C, Wrede JE, Chen ML, Samson M, Reed J, Martin-Washo S, Arp M, Ferri R (2020) Comorbidities in children with elevated periodic limb movement index during sleep. Sleep 43(2):zsz221. https://doi.org/10.1093/sleep/zsz221

    Article  PubMed  Google Scholar 

  84. Gingras JL, Gaultney JF, Picchietti DL (2011) Pediatric periodic limb movement disorder: sleep symptom and polysomnographic correlates compared to obstructive sleep apnea. J Clin Sleep Med 7(6):603–609A. https://doi.org/10.5664/jcsm.1460

    Article  PubMed  PubMed Central  Google Scholar 

  85. Hoque R, Chesson AL Jr (2010) Pharmacologically induced/exacerbated restless legs syndrome, periodic limb movements of sleep, and REM behavior disorder/REM sleep without atonia: literature review, qualitative scoring, and comparative analysis. J Clin Sleep Med 6(1):79–83

    Article  PubMed  PubMed Central  Google Scholar 

  86. Kolla BP, Mansukhani MP, Bostwick JM (2018) The influence of antidepressants on restless legs syndrome and periodic limb movements: a systematic review. Sleep Med Rev 38:131–140. https://doi.org/10.1016/j.smrv.2017.06.002

    Article  PubMed  Google Scholar 

  87. Simakajornboon N, Gozal D, Vlasic V, Mack C, Sharon D, McGinley BM (2003) Periodic limb movements in sleep and iron status in children. Sleep 26(6):735–738. https://doi.org/10.1093/sleep/26.6.735

    Article  PubMed  Google Scholar 

  88. Ferri R, DelRosso LM, Mogavero MP, Bruni O (2021) Periodic limb movement disorder. In: Reference module in neuroscience and biobehavioral psychology. Elsevier. https://doi.org/10.1016/B978-0-12-822963-7.00121-3

    Chapter  Google Scholar 

  89. Melo G, Duarte J, Pauletto P, Porporatti AL, Stuginski-Barbosa J, Winocur E, Flores-Mir C, De Luca CG (2019) Bruxism: an umbrella review of systematic reviews. J Oral Rehabil 46(7):666–690. https://doi.org/10.1111/joor.12801

    Article  PubMed  Google Scholar 

  90. LM DR, Ferri R, Allen RP, Bruni O, Garcia-Borreguero D, Kotagal S, Owens JA, Peirano P, Simakajornboon N, Picchietti DL, International Restless Legs Syndrome Study G (2020) Consensus diagnostic criteria for a newly defined pediatric sleep disorder: restless sleep disorder (RSD). Sleep Med 75:335–340. https://doi.org/10.1016/j.sleep.2020.08.011

    Article  Google Scholar 

  91. DelRosso LM, Ferri R (2019) The prevalence of restless sleep disorder among a clinical sample of children and adolescents referred to a sleep Centre. J sleep Res 28:e12870. https://doi.org/10.1111/jsr.12870

    Article  PubMed  Google Scholar 

  92. DelRosso LM, Bruni O, Ferri R (2020) Heart rate variability during sleep in children and adolescents with restless sleep disorder: a comparison with restless legs syndrome and normal controls. J Clin Sleep Med 16(11):1883–1890. https://doi.org/10.5664/jcsm.8718

    Article  PubMed  PubMed Central  Google Scholar 

  93. DelRosso LM, Hartmann S, Baumert M, Bruni O, Ruth C, Ferri R (2020) Non-REM sleep instability in children with restless sleep disorder. Sleep Med 75:276–281. https://doi.org/10.1016/j.sleep.2020.07.033

    Article  PubMed  Google Scholar 

  94. DelRosso LM, Picchietti DL, Ferri R (2021) Comparison between oral ferrous sulfate and intravenous ferric carboxymaltose in children with restless sleep disorder. Sleep 44(2):zsaa155. https://doi.org/10.1093/sleep/zsaa155

    Article  PubMed  Google Scholar 

  95. Senel GB, Kochan Kizilkilic E, Karadeniz D (2021) Restless sleep disorder in children with NREM parasomnias. Sleep 44(7):zsab049. https://doi.org/10.1093/sleep/zsab049

    Article  PubMed  Google Scholar 

  96. DelRosso LM, Mogavero MP, Ferri R, Bruni O (2022) Restless Sleep disorder (RSD): a new Sleep disorder in children. A rapid review. Curr Neurol Neurosci Rep 22(7):395–404. https://doi.org/10.1007/s11910-022-01200-y

    Article  PubMed  Google Scholar 

  97. Kapoor V, Ferri R, Stein MA, Ruth C, Reed J, DelRosso LM (2021) Restless sleep disorder in children with attention-deficit/hyperactivity disorder. J Clin Sleep Med 17(4):639–643. https://doi.org/10.5664/jcsm.8984

    Article  PubMed  PubMed Central  Google Scholar 

  98. Lin J, Suurna M (2018) Sleep apnea and sleep-disordered breathing. Otolaryngol Clin N Am 51(4):827–833. https://doi.org/10.1016/j.otc.2018.03.009

    Article  Google Scholar 

  99. He K, Kapur VK (2017) Sleep-disordered breathing and excessive daytime sleepiness. Sleep Med Clin 12(3):369–382. https://doi.org/10.1016/j.jsmc.2017.03.010

    Article  PubMed  Google Scholar 

  100. Mogavero MP, Cosentino FII, Lanuzza B, Tripodi M, Lanza G, Arico D, DelRosso LM, Pizza F, Plazzi G, Ferri R (2021) Increased serum prolactin and excessive daytime sleepiness: an attempt of proof-of-concept study. Brain Sci 11(12):1574. https://doi.org/10.3390/brainsci11121574

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  101. Cross N, Lampit A, Pye J, Grunstein RR, Marshall N, Naismith SL (2017) Is obstructive Sleep Apnoea related to neuropsychological function in healthy older adults? A systematic review and meta-analysis. Neuropsychol Rev 27(4):389–402. https://doi.org/10.1007/s11065-017-9344-6

    Article  PubMed  Google Scholar 

  102. Kim HC, Young T, Matthews CG, Weber SM, Woodward AR, Palta M (1997) Sleep-disordered breathing and neuropsychological deficits. A population-based study. Am J Respir Crit Care Med 156(6):1813–1819. https://doi.org/10.1164/ajrccm.156.6.9610026

    Article  CAS  PubMed  Google Scholar 

  103. Zimmerman ME, Aloia MS (2012) Sleep-disordered breathing and cognition in older adults. Curr Neurol Neurosci Rep 12(5):537–546. https://doi.org/10.1007/s11910-012-0298-z

    Article  PubMed  PubMed Central  Google Scholar 

  104. Ancoli-Israel S, Gehrman P, Kripke DF, Stepnowsky C, Mason W, Cohen-Zion M, Marler M (2001) Long-term follow-up of sleep disordered breathing in older adults. Sleep Med 2(6):511–516. https://doi.org/10.1016/s1389-9457(00)00096-4

    Article  CAS  PubMed  Google Scholar 

  105. Adams N, Strauss M, Schluchter M, Redline S (2001) Relation of measures of sleep-disordered breathing to neuropsychological functioning. Am J Respir Crit Care Med 163(7):1626–1631. https://doi.org/10.1164/ajrccm.163.7.2004014

    Article  CAS  PubMed  Google Scholar 

  106. Cosentino FI, Bosco P, Drago V, Prestianni G, Lanuzza B, Iero I, Tripodi M, Spada RS, Toscano G, Caraci F, Ferri R (2008) The APOE epsilon4 allele increases the risk of impaired spatial working memory in obstructive sleep apnea. Sleep Med 9(8):831–839. https://doi.org/10.1016/j.sleep.2007.10.015

    Article  PubMed  Google Scholar 

  107. Young T, Peppard PE, Gottlieb DJ (2002) Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med 165(9):1217–1239. https://doi.org/10.1164/rccm.2109080

    Article  PubMed  Google Scholar 

  108. Farajzadeh M, Hosseini M, Mohtashami J, Chaibakhsh S, Zagheri Tafreshi M, Ghanei Gheshlagh R (2016) The association between obstructive sleep apnea and depression in older adults. Nursing and midwifery studies 5(2):e32585. https://doi.org/10.17795/nmsjournal32585

    Article  PubMed  PubMed Central  Google Scholar 

  109. McEvoy RD, Antic NA, Heeley E, Luo Y, Ou Q, Zhang X, Mediano O, Chen R, Drager LF, Liu Z, Chen G, Du B, McArdle N, Mukherjee S, Tripathi M, Billot L, Li Q, Lorenzi-Filho G, Barbe F, Redline S, Wang J, Arima H, Neal B, White DP, Grunstein RR, Zhong N, Anderson CS, Investigators S, Coordinators (2016) CPAP for prevention of cardiovascular events in obstructive sleep apnea. N Engl J Med 375 (10):919–931. https://doi.org/10.1056/NEJMoa1606599

  110. Martinez-Garcia MA, Campos-Rodriguez F, Catalan-Serra P, Soler-Cataluna JJ, Almeida-Gonzalez C, De la Cruz MI, Duran-Cantolla J, Montserrat JM (2012) Cardiovascular mortality in obstructive sleep apnea in the elderly: role of long-term continuous positive airway pressure treatment: a prospective observational study. Am J Respir Crit Care Med 186(9):909–916. https://doi.org/10.1164/rccm.201203-0448OC

    Article  PubMed  Google Scholar 

  111. Jennum P, Tonnesen P, Ibsen R, Kjellberg J (2017) Obstructive sleep apnea: effect of comorbidities and positive airway pressure on all-cause mortality. Sleep Med 36:62–66. https://doi.org/10.1016/j.sleep.2017.04.018

    Article  PubMed  Google Scholar 

  112. Nishihata Y, Takata Y, Usui Y, Kato K, Yamaguchi T, Shiina K, Yamashina A (2015) Continuous positive airway pressure treatment improves cardiovascular outcomes in elderly patients with cardiovascular disease and obstructive sleep apnea. Heart Vessel 30(1):61–69. https://doi.org/10.1007/s00380-013-0451-x

    Article  Google Scholar 

  113. Bratton DJ, Gaisl T, Schlatzer C, Kohler M (2015) Comparison of the effects of continuous positive airway pressure and mandibular advancement devices on sleepiness in patients with obstructive sleep apnoea: a network meta-analysis. Lancet Respir Med 3(11):869–878. https://doi.org/10.1016/S2213-2600(15)00416-6

    Article  PubMed  Google Scholar 

  114. Marklund M, Franklin KA (2015) Treatment of elderly patients with snoring and obstructive sleep apnea using a mandibular advancement device. Sleep & breathing = Schlaf & Atmung 19(1):403–405. https://doi.org/10.1007/s11325-014-0987-8

    Article  Google Scholar 

  115. Strollo PJ Jr, Soose RJ, Maurer JT, de Vries N, Cornelius J, Froymovich O, Hanson RD, Padhya TA, Steward DL, Gillespie MB, Woodson BT, Van de Heyning PH, Goetting MG, Vanderveken OM, Feldman N, Knaack L, Strohl KP, Group ST (2014) Upper-airway stimulation for obstructive sleep apnea. N Engl J Med 370(2):139–149. https://doi.org/10.1056/NEJMoa1308659

    Article  CAS  PubMed  Google Scholar 

  116. Sommer JU, Hormann K (2017) Innovative surgery for obstructive Sleep apnea: nerve stimulator. Adv Otorhinolaryngol 80:116–124. https://doi.org/10.1159/000470880

    Article  PubMed  Google Scholar 

  117. Moreira GA, Pradella-Hallinan M (2017) Sleepiness in children: an update. Sleep Med Clin 12(3):407–413. https://doi.org/10.1016/j.jsmc.2017.03.013

    Article  PubMed  Google Scholar 

  118. Somma A, Marelli S, Giarolli LE, Maffei C, Ferini-Strambi L, Fossati A (2018) Interview-based ratings of DSM-IV Axis II/DSM-5 section II personality disorder symptoms in consecutively admitted insomnia patients: a comparison study with consecutively admitted psychotherapy patients matched on age and gender. Compr Psychiatry 87:100–106. https://doi.org/10.1016/j.comppsych.2018.09.005

    Article  PubMed  Google Scholar 

  119. Riemann D, Krone LB, Wulff K, Nissen C (2020) Sleep, insomnia, and depression. Neuropsychopharmacology 45(1):74–89. https://doi.org/10.1038/s41386-019-0411-y

    Article  PubMed  Google Scholar 

  120. Picchietti D, Winkelman JW (2005) Restless legs syndrome, periodic limb movements in sleep, and depression. Sleep 28(7):891–898

    PubMed  Google Scholar 

  121. DelRosso LM, Mogavero MP, Baroni A, Bruni O, Ferri R (2021) Restless legs syndrome in children and adolescents. Child Adolesc Psychiatr Clin N Am 30(1):143–157. https://doi.org/10.1016/j.chc.2020.08.010

    Article  PubMed  Google Scholar 

  122. Angriman M, Cortese S, Bruni O (2017) Somatic and neuropsychiatric comorbidities in pediatric restless legs syndrome: a systematic review of the literature. Sleep Med Rev 34:34–45. https://doi.org/10.1016/j.smrv.2016.06.008

    Article  PubMed  Google Scholar 

  123. Ambati A, Hillary R, Leu-Semenescu S, Ollila HM, Lin L, During EH, Farber N, Rico TJ, Faraco J, Leary E, Goldstein-Piekarski AN, Huang YS, Han F, Sivan Y, Lecendreux M, Dodet P, Honda M, Gadoth N, Nevsimalova S, Pizza F, Kanbayashi T, Peraita-Adrados R, Leschziner GD, Hasan R, Canellas F, Kume K, Daniilidou M, Bourgin P, Rye D, Vicario JL, Hogl B, Hong SC, Plazzi G, Mayer G, Landtblom AM, Dauvilliers Y, Arnulf I, Mignot EJ (2021) Kleine-Levin syndrome is associated with birth difficulties and genetic variants in the TRANK1 gene loci. Proc Natl Acad Sci U S A 118(12). https://doi.org/10.1073/pnas.2005753118

  124. Plazzi G, Khatami R, Serra L, Pizza F, Bassetti CL (2010) Pseudocataplexy in narcolepsy with cataplexy. Sleep Med 11(6):591–594. https://doi.org/10.1016/j.sleep.2010.03.004

    Article  PubMed  Google Scholar 

  125. Plazzi G, Ferri R, Antelmi E, Bayard S, Franceschini C, Cosentino FI, Abril B, Spruyt K, Provini F, Montagna P, Dauvilliers Y (2010) Restless legs syndrome is frequent in narcolepsy with cataplexy patients. Sleep 33(5):689–694. https://doi.org/10.1093/sleep/33.5.689

    Article  PubMed  PubMed Central  Google Scholar 

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Mogavero, M.P., Lanza, G., DelRosso, L.M., Ferri, R. (2024). Psychophysiology of Sleep. In: Valeriani, M., de Tommaso, M. (eds) Psychophysiology Methods. Neuromethods, vol 206. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3545-2_12

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