Abstract
3-O-sulfation synthesizes sulfatide in the galactose moiety of galactosylceramide. Sulfatide is expressed in many organs such as the gastrointestinal tract, trachea, kidney, and central nervous system. Influenza A virus binds not only to glycoconjugates terminally containing sialic acid as a viral binding receptor but also to sulfatide not containing sialic acid. On the surface of infected cells, the envelope glycoprotein hemagglutinin of influenza A virus interacts with sulfatide. This interaction enhances the nuclear export of viral ribonucleoprotein complexes, resulting in efficient progeny viruses. Inhibiting this interaction would be a new potent anti-influenza drug that suppresses the progeny virus production in the infected cells.
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Acknowledgments
This work was supported by JSPS KAKENHI Grant numbers, Young Scientists (B) JP20790357, Scientific Research (C) JP23590549, Young Scientists (A) JP15H05644, Scientific Research (B) JP21H03183, and Challenging Exploratory Research JP26670064, JP16K15151, and JP20K21721. This work was partially supported by grants-in-aid from Takeda Science Foundation, Yakurikigakukenkyukai, Tokyo Biochemical Research Foundation, Hamamatsu Scientific Research Foundation, The Research Foundation for Pharmaceutical Sciences, The Public Foundation of Chubu, Science and Technology Center, The Waksman Foundation of Japan Inc., Showa University Medical Foundation, The Uehara Memorial Foundation, The Japan Science Society (20–403), Mizutani Foundation for Glycoscience, Foundation for Promotion of Material Science and Technology of Japan, Adaptable and Seamless Technology Transfer Program through Target-driven R&D (A-STEP) from Japan Science and Technology Agency, CREST from Japan Science and Technology Agency, and the Global COE Program from the Japan Society for the Promotion of Science.
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Takahashi, T., Kurebayashi, Y., Suzuki, T. (2022). Functional Analysis of Sulfatide in Influenza A Virus Infection and Replication. In: Suzuki, Y. (eds) Glycovirology. Methods in Molecular Biology, vol 2556. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2635-1_9
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DOI: https://doi.org/10.1007/978-1-0716-2635-1_9
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