Abstract
Suzuki-Miyaura cross-coupling is one of the most widely employed reactions in medicinal chemistry. Here we describe the efficient cross-coupling with on-DNA halide substrates using Pd(PPh3)4 as coupling catalyst.
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References
Miyaura L (2002) Cross-coupling reactions. Top Curr Chem 219:11
Ding Y, Clark MA (2015) Robust robust Suzuki-Miyaura cross-coupling on DNA-linked substrates. ACS Comb Sci 17(1):1–4
Li JY, Huang H (2018) Development of DNA-compatible Suzuki-Miyaura reaction in aqueous media. Bioconjug Chem 29:3841
Ding Y, DeLorey JL, Clark MA (2016) Novel catalyst system for Suzuki-Miyaura coupling of challenging DNA-linked aryl chlorides. Bioconjug Chem 27(11):2597–2600
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Ding, Y. (2022). On-DNA Suzuki-Miyaura Cross-Coupling. In: Israel, D., Ding, Y. (eds) DNA-Encoded Chemical Libraries. Methods in Molecular Biology, vol 2541. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2545-3_7
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DOI: https://doi.org/10.1007/978-1-0716-2545-3_7
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Publisher Name: Humana, New York, NY
Print ISBN: 978-1-0716-2544-6
Online ISBN: 978-1-0716-2545-3
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