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Survey of Approaches for Investigation of Atherosclerosis In Vivo

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Atherosclerosis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2419))

Abstract

Although in vitro model systems are useful for investigation of atherosclerosis-associated processes, they represent simplification of complex events that occur in vivo, which involve interactions between many different cell types together with their environment. The use of animal model systems is important for more in-depth insights of the molecular mechanisms underlying atherosclerosis and for identifying potential targets for agents that can prevent plaque formation and even reverse existing disease. This chapter will provide a survey of such animal models and associated techniques that are routinely used for research of atherosclerosis in vivo.

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Acknowledgments

DPR and Y-HC thank the British Heart Foundation for financial support (grants PG/16/25/32097 and FS/17/75/33257). AA, RA, and NA received PhD studentships from Kingdom of Saudi Arabia.

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Authors and Affiliations

  1. Cardiff School of Biosciences, Cardiff University, Cardiff, UK

    Dipak P. Ramji, Yee-Hung Chan, Alaa Alahmadi, Reem Alotibi & Nouf Alshehri

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  1. Dipak P. Ramji
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  2. Yee-Hung Chan
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Correspondence to Dipak P. Ramji .

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    Dipak Ramji

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Ramji, D.P., Chan, YH., Alahmadi, A., Alotibi, R., Alshehri, N. (2022). Survey of Approaches for Investigation of Atherosclerosis In Vivo. In: Ramji, D. (eds) Atherosclerosis. Methods in Molecular Biology, vol 2419. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1924-7_4

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  • DOI: https://doi.org/10.1007/978-1-0716-1924-7_4

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