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Testing the Effects of Cinnamon Extract Supplementation on Inflammation and Oxidative Stress Induced by Acrylamide

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Physical Exercise and Natural and Synthetic Products in Health and Disease

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2343))

Abstract

We investigated the effects of cinnamon water extract supplementation on inflammation and oxidative stress induced by acrylamide in rats. This revealed acrylamide-intoxicated control group had significant higher levels of malondialdehyde, tumor necrosis factor-alpha (TNF-α), high-sensitive C-reactive protein (hs-CRP), leptin and alanine transaminase, and lower levels of total antioxidant capacity compared to the negative control group. In contrast, cinnamon extract administration remedied the levels of total antioxidant capacity, malondialdehyde, TNF-α, hs-CRP, and leptin in the treatment groups. However, there was no significant effect on adiponectin or liver enzymes. This chapter presents a protocol involving production of the acrylamide-induced oxidative stress model, the aqueous extraction of cinnamon powder, and measurement of inflammatory and oxidative stress markers.

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Acknowledgments

This work was financially supported by a grant from Nutrition and Metabolic Disease Research Center, Ahvaz Jundishapur University of Medical Sciences (Grant Number: NRC-9414).

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Authors and Affiliations

  1. Department of Nutrition, Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Fatemeh Haidari

  2. Department of Nutrition, Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Majid Mohammadshahi

  3. Department of Nutrition, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Behnaz Abiri & Mojdeh Fathi

  4. Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil

    Paul C. Guest

  5. Department of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

    Mehdi Zarei

Authors
  1. Fatemeh Haidari
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  2. Majid Mohammadshahi
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  3. Behnaz Abiri
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  4. Paul C. Guest
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  5. Mehdi Zarei
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  6. Mojdeh Fathi
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Editors and Affiliations

  1. Charlesworth House, Debden, Essex, UK

    Paul C. Guest

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Haidari, F., Mohammadshahi, M., Abiri, B., Guest, P.C., Zarei, M., Fathi, M. (2022). Testing the Effects of Cinnamon Extract Supplementation on Inflammation and Oxidative Stress Induced by Acrylamide. In: Guest, P.C. (eds) Physical Exercise and Natural and Synthetic Products in Health and Disease. Methods in Molecular Biology, vol 2343. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1558-4_11

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  • DOI: https://doi.org/10.1007/978-1-0716-1558-4_11

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1557-7

  • Online ISBN: 978-1-0716-1558-4

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