Abstract
Recently, great efforts have been focused on understanding and treating reward-related dysfunction in psychiatric disorders. This has led to preclinical and clinical advances in understanding the neurobiology of the reward system, highlighting the case of the field of neuroimaging. In this respect, neuroimaging has an unprecedented potential to unravel the neurobiology of different pathologies, covering a wide spectrum, from structural plasticity in gray and white matter to evoked neuronal responses, neuronal network dynamics, global and regional perfusion and metabolism, receptor-binding studies, or neurotransmitter release. Among the different medical imaging techniques, positron emission tomography (PET), single-photon emission computed tomography (SPECT), or functional magnetic resonance imaging (fMRI) have been extensively applied to study different aspects of mental and psychiatric disorders. Therefore, this chapter focused on molecular neuroimaging of the dopamine reward system by means of PET technique.
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Acknowledgments
Acknowledgments to the Ministerio de Ciencia, Innovación y Universidades, Instituto de Salud Carlos III (PI17/01766) co-funded by European Regional Development Fund (ERDF), “A way of making Europe,” CIBERSAM, Delegación del Gobierno para el Plan Nacional sobre Drogas (2017/085), Fundación Alicia Koplowitz, Consejería de Educación e Investigación, Comunidad de Madrid, co-funded by European Social Fund “Investing in your future” (PEJD-2018-PRE/BMD-7899, PEJ-2017-TL/BMD-7385) and Fundación Tatiana Pérez de Guzmán el Bueno.
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Romero-Miguel, D., Lamanna-Rama, N., Casquero-Veiga, M., Gómez-Rangel, V., Desco, M., Soto-Montenegro, M.L. (2021). Positron Emission Tomography of the Reward System. In: Fakhoury, M. (eds) The Brain Reward System. Neuromethods, vol 165. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1146-3_14
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