Abstract
Metastasis formation is the leading cause of death in cancer patients. It has recently emerged that cancer cells adapt their metabolism to successfully transition through the metastatic cascade. Consequently, measuring and analyzing the in vivo metabolism of metastases has the potential to reveal novel treatment strategies to prevent metastasis formation. Here, we describe two different metastasis mouse models and how their metabolism can be analyzed with metabolomics and 13C tracer analysis.
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Altea-Manzano, P., Broekaert, D., Duarte, J.A.G., Fernández-García, J., Planque, M., Fendt, SM. (2020). Analyzing the Metabolism of Metastases in Mice. In: Nagrath, D. (eds) Metabolic Flux Analysis in Eukaryotic Cells. Methods in Molecular Biology, vol 2088. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0159-4_6
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DOI: https://doi.org/10.1007/978-1-0716-0159-4_6
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