Prevalence in Britain of abnormal prion protein in human appendices before and after exposure to the cattle BSE epizootic O. Noel GillYvonne SpencerSebastian Brandner Original Paper Open access 30 March 2020 Pages: 965 - 976
The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies Anke Van der PerrenGéraldine GeldersVeerle Baekelandt Original Paper Open access 30 April 2020 Pages: 977 - 1000
Mutated ATP10B increases Parkinson’s disease risk by compromising lysosomal glucosylceramide export Shaun MartinStefanie SmoldersThe BELNEU consortium Original Paper Open access 14 March 2020 Pages: 1001 - 1024
PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment Luca KleineidamVincent ChourakiAlfredo Ramirez Original Paper Open access 12 March 2020 Pages: 1025 - 1044
Diverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT-P301L mutation Nathalie DaudeChae KimDavid Westaway Original Paper Open access 26 March 2020 Pages: 1045 - 1070
Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition Gourish MondalJulieann C. LeeDavid A. Solomon Original Paper 17 April 2020 Pages: 1071 - 1088
Intracellular calcium leak as a therapeutic target for RYR1-related myopathies Alexander KushnirJoshua J. ToddAndrew R. Marks Original Paper 31 March 2020 Pages: 1089 - 1104
Concomitant 1p/19q co-deletion and IDH1/2, ATRX, and TP53 mutations within a single clone of “dual-genotype” IDH-mutant infiltrating gliomas Cinthya J. Zepeda-MendozaRachael A. VaubelRobert B. Jenkins Correspondence 13 March 2020 Pages: 1105 - 1107
Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation David CastelThomas KergrohenMarie-Anne Debily Correspondence 19 March 2020 Pages: 1109 - 1113
Pineoblastoma is uniquely tolerant of mutually exclusive loss of DICER1, DROSHA or DGCR8 Leanne de KockBarbara RiveraWilliam D. Foulkes Correspondence 02 March 2020 Pages: 1115 - 1118
Complement deposition at the neuromuscular junction in seronegative myasthenia gravis Sarah HoffmannLutz HarmsAndreas Meisel Correspondence Open access 10 March 2020 Pages: 1119 - 1122