Urolithiasis - Collection: Oxidative Stress, Inflammation and Kidney Stones
Urinary or kidney stone disease aka, urolithiasis and nephrolithiasis is relatively common and is on the rise globally.
Recent studies indicate increased expression of genes related to production of reactive oxygen species (ROS), inflammation and immunity in the renal tissue of stone formers as well as those of rats with experimentally induced hyperoxaluria and CaOx nephrolithiasis. Stone formation is also associated with other diseases with similar involvement of ROS, immunity and inflammation such as hypertension, diabetes, chronic kidney disease and end stage renal disease. Experimental as well as clinical data show critical involvement of cells implicated in immune system in the pathogenesis of nephrolithiasis.
In order to shed more light on this topic, we have set up a collection entitled Oxidative Stress, Inflammation and Kidney Stones.
The purpose of this collection is to bring together up-to-date reviews and original articles that highlight current understanding of stone pathogenesis with respect to the involvement of ROS, immunity and inflammatory molecules in the formation of kidney stones. This may help move the field forward and develop pathogenesis-based treatment options which may already be available and in use as treatments for stone co-morbidities.
If you would like to contribute to this topic, we look forward to receiving your submission, which you can submit here.
Guest Editor
Saeed R. Khan, M.Sc., Ph.D., FASN
Emeritus Professor, Department of Pathology and Laboratory Medicine
College of Medicine, University of Florida, Gainesville, Florida, USA
Dr. Khan is interested in understanding the pathogenesis of calcium oxalate kidney stones. To that end he has used both in vivo and in vitro techniques, using animal models, cell cultures as well as artificial crystallizers. His research has been supported by National Institutes of Health (NIH) through a variety of grants, including R21, RO1, PO1 as well as a Training grant. He also served on panels reviewing kidney stone related research grant applications submitted to the NIH and other organizations.
Dr. Khan has published more than 400 scholarly articles: reviews, book chapters and nearly 200 refereed articles. He regularly reviews manuscripts for scholarly journals and is currently an associate editor for the journal, Urolithiasis (formerly Urological Research). He has also edited proceedings of the international symposia on urolithiasis, in addition to a book entitled Calcium Oxalate in Biological Systems.
Dr. Khan organized two Finlayson Symposia on Urolithiasis at the University of Florida with proceedings being published in Journal of the American Society of Nephrology and Journal of Endourology. He had significant involvement in national and international professional associations, serving as:
• The president of the Florida Society for Microscopy;
• The president of the R.O.C.K. (Research on Calculus
Kinetics) Society (in 1999); and
• A member of the advisory boards of both the International Symposia
on Urolithiasis and the European Symposia on Urolithiasis.
An experienced speaker, Dr. Khan has also given keynote addresses, and plenary and state-of-the-art lectures at conferences and symposia, both at domestic and international meetings across the globe. For his outstanding career accomplishments, Dr. Khan has received:
• The University of Florida Research Achievement Award;
• The University of Florida College of Medicine Faculty Research
Prize in Basic Science;
• University of Florida Research Foundation Professorship;
• Honorary Award at the 13th International Symposium on Urolithiasis
held in Chiba, Japan;
• College of Medicine Lifetime Achievement Award
• “Unbreakable” Lifetime Achievement Award by the American
Urological Association and the ROCK Society