Pulmonary Delivery of Peptide Drugs: Effect of Particle Size on Bioavailability of Leuprolide Acetate in Healthy Male Volunteers Akwete AdjeiJulie Garren OriginalPaper Pages: 565 - 569
Simultaneous Modeling of the Pharmacokinetic and Pharmacodynamic Properties of Benzodiazepines. II. Triazolam Samir K. GuptaEverett H. EllinwoodDouglas G. Heatherly OriginalPaper Pages: 570 - 576
Development of a Preformulation Lipophilicity Screen Utilizing a C-18-Derivatized Polystyrene-Divinylbenzene High-Performance Liquid Chromatographic (HPLC) Column William J. LambertLatrelle A. Wright OriginalPaper Pages: 577 - 586
Pharmacokinetics of a Mouse/Human Chimeric Monoclonal Antibody (C-17-1 A) in Metastatic Adenocarcinoma Patients John M. TrangAlbert F. LoBuglioM. B. Khazaeli OriginalPaper Pages: 587 - 592
Chemical Pathways of Peptide Degradation. I. Deamidation of Adrenocorticotropic Hormone Neelima P. BhattKamlesh PatelRonald T. Borchardt OriginalPaper Pages: 593 - 599
Testing of Insulin Hexamer-Stabilizing Ligands Using Theoretical Binding, Microcalorimetry, and Nuclear Magnetic Resonance (NMR) Line Broadening Techniques Scott E. McGrawDavid J. CraikSiegfried Lindenbaum OriginalPaper Pages: 600 - 605
The Use of Microcalorimetry to Measure Thermodynamic Parameters of the Binding of Ligands to Insulin Scott E. McGrawSiegfried Lindenbaum OriginalPaper Pages: 606 - 611
Pharmaceutical Usefulness of Hydroxypropylcyclodextrins: "E Pluribus Unum” Is an Essential Feature C. Trinadha RaoHenry M. FalesJosef Pitha OriginalPaper Pages: 612 - 615
Formulation and Dosage Form Design in Drug-Induced Topical Irritation of the Gastrointestinal Tract John W. FaraRobert E. Myrback OriginalPaper Pages: 616 - 620
Oleic Acid: Its Effects on Stratum Corneum in Relation to (Trans)Dermal Drug Delivery Michael L. FrancoeurGuia M. GoldenRussell O. Potts OriginalPaper Pages: 621 - 627
Constant-Rate Intravenous Infusion Methods for Estimating Steady-State Volumes of Distribution and Mean Residence Times in the Body for Drugs Undergoing Reversible Metabolism Haiyung ChengWilliam J. Jusko OriginalPaper Pages: 628 - 632
Binding of Drugs in Milk: The Role of Casein in Milk Protein Binding Thomas SteblerTheodor W. Guentert OriginalPaper Pages: 633 - 637
Metabolic Conversion of Cyoctol During Skin Passage in Humans Rokus A. de ZeeuwRenella E. HerderBen F. H. Drenth OriginalPaper Pages: 638 - 643
Effect of Dextran Sulfate on Renal Accumulation of Gentamicin Shinji KikuchiYukihiko AramakiSeishi Tsuchiya OriginalPaper Pages: 644 - 647
The Effect of Physical Aging on the Dissolution Rate of Anionic Polyelectrolytes Christopher M. SinkoAlbert F. YeeGordon L. Amidon OriginalPaper Pages: 648 - 653
The Relationship Between the Glass Transition Temperature and Water Vapor Absorption by Poly(vinylpyrrolidone) Cynthia A. OksanenGeorge Zografi OriginalPaper Pages: 654 - 657
Application of a Brain-Targeting Chemical Delivery System to 9-Amino-1,2,3,4-Tetrahydroacridine Emil PopKatalin Prókai-TátraiNicholas Bodor OriginalPaper Pages: 658 - 664
Characterization of Epidermal Growth Factor Receptors on Plasma Membranes Isolated from Rat Gastric Mucosa Ryohei HoriHisashi NomuraKatsuhiko Okumura OriginalPaper Pages: 665 - 669
Effects of Amantadine on Dopaminergic Neurons in Discrete Regions of the Rat Brain Katsuo Toide OriginalPaper Pages: 670 - 672
Comparisons of in Vitro Nitroglycerin (TNG) Flux Across Yucatan Pig, Hairless Mouse, and Human Skins Mary E. RobertsKarl R. Mueller Note Pages: 673 - 676
Influence of Absorption Rate, Dosing Frequency, and Intrinsic Pharmacokinetic Profile on Steady-State Drug Concentrations Michael A. EldonWayne A. Colburn Note Pages: 677 - 680