News from the National Institute of General Medical Sciences (NIGMS) W. Sue Shafer News Pages: 1495 - 1497
Therapeutic Targets for Hypoxia-Elicited Pathways Cormac T. TaylorSean P. Colgan ReviewPaper Pages: 1498 - 1505
Molecular Modeling Study of Diltiazem Mimics at L-Type Calcium Channels Klaus-Jürgen SchleiferEdith Tot OriginalPaper Pages: 1506 - 1513
Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugs Jan KelderPeter D. J. GrootenhuisJan-Peter Ploemen OriginalPaper Pages: 1514 - 1519
Prediction of the Intestinal Absorption of Endothelin Receptor Antagonists Using Three Theoretical Methods of Increasing Complexity Patric StenbergKristina LuthmanPer Artursson OriginalPaper Pages: 1520 - 1526
Prodrug Approach for αΙΙbβ3-Peptidomimetic Antagonists to Enhance Their Transport in Monolayers of a Human Intestinal Cell Line (Caco-2): Comparison of In Vitro and In Vivo Data Walter KammPeter RaddatzThomas Kissel OriginalPaper Pages: 1527 - 1533
Association and Dissociation Characteristics of Polymer/DNA Complexes Used for Gene Delivery Carmen ArigitaNicolaas Jan ZuidamWim E. Hennink OriginalPaper Pages: 1534 - 1541
Distribution of a 20-Mer Phosphorothioate Oligonucleotide, CGP69846A (ISIS 5132), into Airway Leukocytes and Epithelial Cells Following Intratracheal Delivery to Brown-Norway Rats Henry DanahayJune GiddingsJudy A. Phillips OriginalPaper Pages: 1542 - 1549
Inhibition of P-Glycoprotein by D-α-Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS) Jay M. DintamanJeffrey A. Silverman OriginalPaper Pages: 1550 - 1556
Oral Mucosal Permeability and Stability of Transforming Growth Factor Beta-3 In Vitro Christopher A. SquierMary J. KremerJohn D. Haley OriginalPaper Pages: 1557 - 1563
Significant Transport of Doxorubicin into the Brain with Polysorbate 80-Coated Nanoparticles Alexander E. GulyaevSvetlana E. GelperinaJörg Kreuter OriginalPaper Pages: 1564 - 1569
Epithelial Transport of Anthelmintic Ivermectin in a Novel Model of Isolated Proximal Kidney Tubules Gert FrickerHeike GutmannDavid S. Miller OriginalPaper Pages: 1570 - 1575
Enhancement of Nasal Absorption of Insulin Using Chitosan Nanoparticles Rocío Fernández-UrrusunoPilar CalvoMaría José Alonso OriginalPaper Pages: 1576 - 1581
Stereoselective Pharmacokinetics and Pharmacodynamics of Propylisopropyl Acetamide, a CNS-Active Chiral Amide Analog of Valproic Acid Ofer SpiegelsteinBoris YagenMeir Bialer OriginalPaper Pages: 1582 - 1588
Effects of Disopyramide and Verapamil on Renal Disposition and Nephrotoxicity of Cisplatin in Rats Kazuhiko HanadaKentaro OdakaHiroyasu Ogata OriginalPaper Pages: 1589 - 1595
Characterization of Ocular Pharmacokinetics of Beta-Blockers Using a Diffusion Model After Instillation Kenzo YamamuraHitoshi SasakiJunzo Nakamura OriginalPaper Pages: 1596 - 1601
Percutaneous Absorption of Sunscreens Through Micro-Yucatan Pig Skin In Vitro Vinod K. GuptaJoel L. ZatzMark Rerek OriginalPaper Pages: 1602 - 1607
A Pharmacokinetic Model for Tenidap in Normal Volunteers and Rheumatoid Arthritis Patients Lynne EvansLeon AaronsPeter Coates OriginalPaper Pages: 1608 - 1615
Suppression of Agglomeration in Fluidized Bed Coating. III. Hofmeister Series in Suppression of Particle Agglomeration Tatsu NakanoHiroshi YuasaYoshio Kanaya OriginalPaper Pages: 1616 - 1620
Molecular Mobility of Protein in Lyophilized Formulations Linked to the Molecular Mobility of Polymer Excipients, as Determined by High Resolution 13C Solid-State NMR Sumie YoshiokaYukio AsoHideo Akutsu OriginalPaper Pages: 1621 - 1625
Inhibition of Succinimide Formation in Aqueous Zn-rHirudin Suspensions1 Ursula GietzTudor ArvinteHans P. Merkle OriginalPaper Pages: 1626 - 1632
Ion-Pair Partition of Quaternary Ammonium Drugs: The Influence of Counter Ions of Different Lipophilicity, Size, and Flexibility Krisztina Takács-NovákGyörgy Szász OriginalPaper Pages: 1633 - 1638
A New Microphotolysis Based Approach for Mapping the Mobility of Drugs in Microscopic Drug Delivery Devices Stefaan C. De SmedtTom K. L. MeyvisJoseph Demeester BriefCommunication Pages: 1639 - 1642
Enhancement of Small Particle Size Dry Powder Aerosol Formulations using an Ultra Low Density Additive Paul LucasKerry AndersonJohn N. Staniforth BriefCommunication Pages: 1643 - 1647
Comparison of Nasal Deposition and Clearance of Aerosol Generated by a Nebulizer and an Aqueous Spray Pump Julie D. SumanBeth L. LaubeRichard Dalby BriefCommunication Pages: 1648 - 1652
Effect of Baicalin on Tracheal Permeability in Ovalbumin (OA)-Sensitized Guinea Pigs Jiahorng LiawYi-Ying GauYen-Chin Chao BriefCommunication Pages: 1653 - 1657
1H NMR Quantification of poly(Ethylene Glycol)-Phosphatidylethanolamine in Phospholipid Mixtures E. A. A. M. VernooijC. A. GentryJ. J. Kettenes-van den Bosch BriefCommunication Pages: 1658 - 1661